Stereochemical investigations on intermediates for the synthesis of histamine H 2 receptor agonists and neuropeptide Y Y 1 antagonists: Chiral separation of phenyl(pyridyl)alkanoic acids by HPLC and CE

Scientia Pharmaceutica

Volumn 66, Issue 4, 1998, Pages 263-278

  Schuster, A ^a   Bollwein, S ^a   Uffrecht, A ^a   Krey, V ^a   Gotte C ^a   Bernhardt, G ^a   Buschauer, A ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

CE; Circular dichroism; Diastereomer separation; Enantiomer separation; HPLC; Phenylpyridylalkanoic acids

Indexed keywords

2 HYDROXYPROPYL ALPHA CYCLODEXTRIN; 2 HYDROXYPROPYL BETA CYCLODEXTRIN; 3 (3,4 DIFLUOROPHENYL) 3 (2 PYRIDYL)PROPANOIC ACID; 4 (3,4 DICHLOROPHENYL) 4 (2 PYRIDYL)BUTANOIC ACID; 4 (3,4 DIFLUOROPHENYL) 4 (2 PYRIDYL)BUTANOIC ACID; CYCLODEXTRIN DERIVATIVE; HISTAMINE H2 RECEPTOR AGONIST; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROPEPTIDE Y1 RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CAPILLARY ZONE ELECTROPHORESIS; CHIRALITY; CIRCULAR DICHROISM; DIASTEREOISOMER; DRUG SYNTHESIS; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PH; STEREOCHEMISTRY; TEMPERATURE;

EID: 0032583547     PISSN: 00368709     EISSN: 22180532     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Buschauer A. (1989). J. Med. Chem. 32: 1963-1970.
2. Felix S. B., Buschauer A., Baumann G. (1995). Eur. J. Clin. Invest. 25 Suppl. 1: 42-46.
3. Aiglstorfer I., Uffrecht A., Gessele K., Moser C., Schuster A., Merz S., Malawska B., Bernhardt G., Dove S., Buschauer A. (1998). Regul. Pept.: in press.
4. Uffrecht A. (1996). Doctoral thesis. Freie Universität Berlin, Berlin, Germany.
5. Krey V. (1997) Diploma thesis, University of Regensburg, Regensburg, Germany.
6. Götte C (1998). Diploma thesis, University of Regensburg, Regensburg, Germany.
7. Altira K. D. (1993). Chromatographia 35(3-4): 177-182.
8. Fanali S., Bocek P. (1990). Electrophoresis 11: 757-760.
9. Testa B. (1974). In: Bergmann E.D., Pullman B. (eds.) Molecular and quantum pharmacology. D. Reidel Publishing Company, Dordrecht: pp. 241-259.