Synthesis and evaluation of antimycobacterial activity of 4-phenyl-1,8-naphthyridine derivatives

Farmaco

Volumn 53, Issue 12, 1998, Pages 741-746

  Luigi Ferrarini, Pier ^a   Manera, Clementina ^a   Mori, Claudio ^a   Badawneh, Muwaffag ^b   Saccomanni, Giuseppe ^a  

^a UNIVERSITY OF PISA   (Italy)

^b PHILADELPHIA UNIVERSITY   (Jordan)

Author keywords

1,8 Naphthyridines; Piperazino derivatives; Tuberculostatic agents

Indexed keywords

4 PHENYL 1,8 NAPHTHYRIDINE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; MYCOBACTERIUM TUBERCULOSIS; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTITUBERCULAR AGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; NAPHTHYRIDINES;

EID: 0032583464     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(98)00094-9     Document Type: Article

References (13)

1. Vigorita M.G., Ottanà R., Zappalà C., Maccari R., Pizzimenti F.C., Gabrielli G. Halogenated isoniazid derivatives as possible antimycobacterial and anti-HIV agents-III. Farmaco. 49:1994;775-781.
2. Haruaki T., Katsumasa S., Hajime S., Yoshifumi I. Chem. Abstr. 119:1993;266305x.
3. Trivedi P.B., Undavia N.K., Dave M.A., Bhatt K.N., Desai N.C. Synthesis and antimicrobial activity of some heterocyclic compounds. Indian J. Chem. Sect. B. 32:1993;497-500. (Chem. Abstr. 119 (1993) 49341b).
4. Shah B.R., Bhatt J.J., Patel H.H., Undavia N.K., Trivedi P.B., Desai N.C. Synthesis of 2,3-disubstituted-3,1-quinazolin-4(4H)-ones as potential anticancer and anti-HIV agents. Indian J. Chem. Sect. B. 34:1995;201-208. (Chem. Abstr. 123 (1995) 33013t).
5. Khalifa M., El-Basil S., Youssef K.M. Synthesis of some quinazolone derivatives with tuberculostatic activity. Zagazig J. Pharm. Sci. 4:1995;287-293. (Chem. Abstr. 124 (1996) 86925).
6. Desai P.K., Desai P., Machhi D., Desai C.M., Patel D. Quinoline derivatives as antitubercular/antibacterial agents. Indian J. Chem. Sect. B. 35:1996;871-873. (Chem. Abstr. 125 (1996) 221530).
7. Ferrarini P.L., Mori C., Badawneh M., Manera C., Martinelli A., Miceli M., Romagnoli F., Saccomanni G. Unusual nitration of substituted 7-amino-1,8-naphthyridine in the synthesis of compounds with antiplatelet activity. J. Heterocyclic Chem. 34:1997;1501-1510.
8. Mangini A., Colonna M. Contributo alla conoscenza delle naftiridine. Gazz. Chim. Ital. 72:1942;183-197.
9. Collins L.A., Franzblau S.G. Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium. Antimicrob. Agents Chemother. 42:1997;1004-1009.
10. Ferrarini P.L., Mori C., Biagi G., Livi O., Tonetti I. Synthesis of bis(2-chloroethyl)amino-1,8-naphthyridines for evaluation as anticancer agents. J. Heterocyclic Chem. 21:1984;417-419.
11. Ferrarini P.L., Mori C., Miceli M., Franconi F. Synthesis and antiplatelet activity of some 1,8-naphthyridine derivatives. Eur. J. Med. Chem. 29:1994;735-741.
12. Carboni S., Da Settimo A., Bertini D., Ferrarini P.L., Livi O., Tonetti I. Sintesi ed attività biologica di alcune 1,8-naftiridine. Farmaco Ed. Sci. 28:1973;722-732.
13. Carboni S., Da Settimo A., Ferrarini P.L., Tonetti I. Ricerche nel campo delle antiridine. Gazz. Chim. Ital. 97:1967;1262-1273.