Identification of a nuclear protein in Trypanosoma brucei with homology to RNA-binding proteins from cis-splicing systems

Molecular and Biochemical Parasitology

Volumn 97, Issue 1-2, 1998, Pages 1-11

  Manger, Ian D ^a   Boothroyd, John C ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

RNA recognition motif; RNA binding protein; Trans splicing; Trypanosoma brucei

Indexed keywords

RNA BINDING PROTEIN; ZINC FINGER PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; IMMUNOFLUORESCENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECOGNITION; RNA SPLICING; TRYPANOSOMA BRUCEI; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CLONING, MOLECULAR; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENES, PROTOZOAN; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; OPEN READING FRAMES; POLYMERASE CHAIN REACTION; PROTOZOAN PROTEINS; RNA, PROTOZOAN; RNA-BINDING PROTEINS; SEQUENCE ALIGNMENT; TRANS-SPLICING; TRYPANOSOMA BRUCEI BRUCEI;

EUKARYOTA; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0032583099     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(98)00118-2     Document Type: Article

References (42)

1. Clayton C. Developmental regulation of nuclear gene expression in Trypanosoma brucei. Prog Nucl Acid Res Mol Biol. 43:1992;37-66.
2. Graham S.V. Mechanisms of stage-regulated gene expression in kinetoplastida. Parasitol Today. 11:1995;217-223.
3. Roditi I. The VSG-procyclin Switch. Parasitol Today. 12:1996;47-49.
4. Ullu E, Tschudi C and Gunzl A (1996) Trans-splicing in trypanosomatid protozoa. Smith, DF And M Parsons (Eds.). Frontiers In Molecular Biology. Molecular Biology Of Parasitic Protozoa (Vol. 13), pp. 115-133.
5. Hehl A., Vassella E., Braun R., Roditi I. A conserved stem-loop structure in the 3′ untranslated region of procyclin mRNAs regulates expression in Trypanosoma brucei. Proc Natl Acad Sci. 91:1994;370-374.
6. Hotz H.R., Lorenz P., Fischer R., Krieger S., Clayton C. Role of 3′-untranslated regions in the regulation of hexose transporter mRNAs in Trypanosoma brucei. Mol Biochem Parasitol. 75:1995;1-14.
7. Hotz H.R., Hartmann C., Huober K., Hug M., Clayton C. Mechanisms of developmental regulation in Trypanosoma brucei: a polypyrimidine tract in the 3′-untranslated region of a surface protein mRNA affects RNA abundance and translation. Nucl Acids Res. 25:1997;3017-3025.
8. Schuerch N., Furger A., Kurath U., Roditi I. Contributions of the procyclin 3′ untranslated region and coding region to the regulation of expression in bloodstream forms of Trypanosoma brucei. Mol Biochem Parasitol. 89:1997;109-121.
9. Burd C.G., Dreyfuss G. Conserved structures and diversity of functions of RNA-binding proteins. Science. 265:1994;615-621.
10. Nagai K., Oubridge C., Ito N., Avis J., Evans P. The RNP domain: a sequence-specific RNA-binding domain involved in processing and transport of RNA. Trends Biochem Sci. 20:1995;235-240.
11. Kanaar R., Lee A.L., Rudner D.Z., Wemmer D.E., Rio D.C. Interaction of the sex-lethal RNA binding domains with RNA. EMBO J. 14:1995;4530-4539.
12. Birney E., Kumar S., Krainer A.R. Analysis of the RNA-recognition motif and RS and RGG domains: Conservation in metazoan pre-mRNA splicing factors. Nucl Acids Res. 21:1993;5803-5816.
13. Kim Y.J., Baker B.S. Isolation of RRM-type RNA-binding protein genes and the analysis of their relatedness by using a numerical approach. Mol Cell Biol. 13:1993;174-183.
14. Matthews K.R., Tschudi C., Ullu E. A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes. Genes Dev. 8:1994;491-501.
15. Kapotas N., Bellofatto V. Differential response to RNA trans-splicing signals within the phosphoglycerate kinase gene cluster in Trypanosoma brucei. Nucl Acids Res. 21:1993;4067-4072.
16. Roth M.B., Zahler A.M., Stolk J.A. A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription. J Cell Biol. 115:1991;587-596.
17. Oubridge C., Ito N., Evans P.R., Teo C.H., Nagai K. Crystal structure at 1.92 a resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. Nature. 372:1994;432-438.
18. Shamoo Y., Abdul-Manan N., Williams K.R. Multiple RNA binding domains (RBDs) just don't add up. Nucl Acids Res. 23:1995;725-728.
19. Robinow S., Campos A.R., Yao K-M, White K. The elav gene product of Drosophila, required in neurons has three RNP consensus motifs. Science. 242:1988;1570-1572.
20. South T.L., Blake P.R., Sowder R.C.I., Arthur L.O., Henderson L.E., Summers M.F. The nucleocapsid protein isolated from HIV-1 particles binds zinc and forms retroviral-type zinc fingers. Biochemistry. 29:1990;7786-7789.
21. Gorelick R.J., Nigida S.M. Jr, Bess J.W. Jr, Arthur L.O., Henderson L.E., Rein A. Mutations in the zinc finger-like region of HIV-1 nucleocapsid yield non-infectious particles deficient in genomic RNA. Aids Res Hum Retroviruses. 7:1991;194.
22. Gorlick R.J., Chabot D.D., Rein A., Henderson L.E., Arthur L.O. The two zinc fingers in the human immunodeficiency virus type 1 nucleocapsid protein are not functionally equivalent. J Virol. 67:1993;4027-4036.
23. Zhang Y., Barklis E. Nucleocapsid protein effects on the specificity of retrovirus RNA encapsidation. J Virol. 69:1995;5716-5722.
24. Khan R., Giedroc D.P. Recombinant human immunodeficiency virus type 1 nucleocapsid (NCp7) protein unwinds tRNA. J Biol Chem. 267:1992;6689-6695.
25. Rice W.G., Turpin J.A. Virus-encoded zinc fingers as targets for antiviral chemotherapy. Rev Med Virol. 6:1996;187-199.
26. Flink I.L., Morkin E. Alternatively processed isoforms of cellular nucleic acid-binding protein interact with a suppressor region of the human beta-myosin heavy chain gene. J Biol Chem. 270:1995;6959-6965.
27. Xu H.P., Rajavashisth T., Grewal N. et al. A gene encoding a protein with seven zinc finger domains acts on the sexual differentiation pathways of Schizosaccharomyces pombe. Mol Biol Cell. 3:1992;721-734.
28. Webb J.R., McMaster W.R. Leishmania major HEXBP deletion mutants generated by double targeted gene replacement. Mol Biochem Parasitol. 63:1994;231-242.
29. Tzfati Y., Abeliovich H., Avraham D., Shlomai J. Universal minicircle sequence binding protein, a CCHC-type zinc finger protein that binds the universal minicircle sequence of trypanosomatids: purification and characterization. J Biol Chem. 270:1995;21339-21345.
30. Cavaloc Y., Popielarz M., Fuchs J.P., Gattoni R., Stevenin J. Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family. EMBO J. 13:1994;2639-2649.
31. Frank D., Guthrie C. An essential splicing factor, SLU7, mediates 3′ splice site choice in yeast. Genes Dev. 6:1992;2112-2124.
32. Jones M.H., Frank D.N., Guthrie C. Characterization and functional ordering of SLU7p and PRP17p during the second step of pre-mRNA splicing in yeast. Proc Nat Acad Sci. 92:1995;9687-9691.
33. Kramer A. The structure and function of proteins involved in mammalian pre-mRNA splicing. Richardson CC (Ed.). Annu Rev Biochem 1996;65:367-409.
34. Wu J.Y., Maniatis T. Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell. 75:1993;1061-1070.
35. Spector D.L. Macromolecular domains within the cell nucleus. Annu Rev Cell Biol. 9:1993;265-315.
36. Zhang G., Taneja K.L., Singer R.H., Green M.R. Localization of pre-mRNA splicing in mammalian nuclei. Nature. 372:1994;809-812.
37. Marchal C., Ismaili N., Pays E. A ribosomal S12-like gene of Trypanosoma brucei. Mol Biochem Parasitol. 57:1993;331-334.
38. Batista J.A.N., Teixeira S.M.R., Donelson J.E., Kirchhoff L.V., Sa C.M.D. Characterization of a Trypanosoma cruzi Poly(A)-binding protein and its genes. Mol Biochem Parasitol. 67:1994;301-312.
39. Zhang J., Williams N. Purification, cloning, and expression of two closely related Trypanosoma brucei. nucleic acid binding proteins. Mol Biochem Parasitol. 87:1997;145-158.
40. El-Sayed N.M.A., Alarcon C.M., Beck J.C., Sheffield VC.and, Donelson J.E. cDNA expressed sequence tags of Trypanosoma brucei. rhodesiense provide new insights into the biology of the parasite. Mol Biochem Parasitol. 73:1995;75-90.
41. Palfi Z., Bindereif A. Immunological characterization and intracellular localization of trans-spliceosomal small nuclear ribonucleoproteins in Trypanosoma brucei. J Biol Chem. 267:1992;20159-20163.
42. Ullu E., Tschudi C. Permeable trypanosome cells as a model system for transcription and trans-splicing. Nucleic Acids Res. 18:1990;3319-3326.