Preparation and diastereoselective birch reduction - Alkylation of chiral 3,4-dihydro-1(2H)-isoquinolinones. Enantiospecific syntheses and opioid receptor affinities of several hydro-2,3-dimethyl-1H-7,12α- methanobenzo[6,7]cycloocta[1,2-c]pyridine-9-ols

Journal of Organic Chemistry

Volumn 63, Issue 22, 1998, Pages 7795-7804

  Schultz, Arthur G ^a   Guzi, Timothy J ^a   Larsson, Erika ^a   Rahm, Rainer ^a   Thakkar, Kshitij ^a   Bidlack, Jean M ^b  

^a Rensselaer Polytechnic Institute   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,4,4A,5,6,7,12 OCTAHYDRO 9 HYDROXY 2,3 DIMETHYL 1H 7,12A METHANOBENZO[6,7]CYCLOOCTA[1,2 C]PYRIDIN 6 ONE; 2,3,4,6,7,12 HEXAHYDRO 2,3 DIMETHYL 1H 7,12A METHANOBENZO[6,7]CYCLOOCTA[1,2 C]PYRIDIN 9 OL; 2,3,4,6,7,12 HEXAHYDRO 2,3 DIMETHYL 1H 7,12A METHANOBENZO[6,7]CYCLOOCTA[1,2 C]PYRIDINE 6,9 DIOL; 3,4 DIHYDRO 1(2H) ISOQUINOLINONE DERIVATIVE; 3,4 DIHYDRO 2,3 DIMETHYL 1(2H) ISOQUINOLINONE; 3,4 DIHYDRO 3 TERT BUTYLDIMETHYLSILOXYMETHYL 2 METHYL 1(2H) ISOQUINOLINONE; ANALGESIC AGENT; DELTA OPIATE RECEPTOR; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ISOQUINOLINE DERIVATIVE; KAPPA OPIATE RECEPTOR; LEVORPHANOL; MU OPIATE RECEPTOR; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NALTRINDOLE; OPIATE RECEPTOR; PYRIDINE DERIVATIVE; TRITIUM; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; CATTLE; CHIRALITY; CORPUS STRIATUM; DIASTEREOISOMER; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; INHIBITION KINETICS; NONHUMAN; RECEPTOR AFFINITY; REDUCTION;

EID: 0032582746     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo980921g     Document Type: Article

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