Nicotinic receptors are regulated by protein kinase C activated via a nicotinic receptors-mediated signaling pathway

Molecular Brain Research

Volumn 61, Issue 1-2, 1998, Pages 211-218

  Nishizaki, Tomoyuki ^a   Sumikawa, Katumi ^b  

^a KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Nicotinic acetylcholine receptor; Protein kinase C; Single channel recording; Site directed mutagenesis; Xenopus oocyte

Indexed keywords

ACETYLCHOLINE; BLOCKING AGENT; CHOLINERGIC RECEPTOR; MUTANT PROTEIN; NICOTINIC RECEPTOR; PHOSPHATIDYLINOSITOL; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; STAUROSPORINE;

ARTICLE; CONDUCTANCE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENETIC REGULATION; MOUSE; MUSCLE SPINDLE; NONHUMAN; OOCYTE; PATCH CLAMP; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; XENOPUS;

ANIMALS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; MICE; MICROINJECTIONS; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN KINASE C; RECEPTORS, NICOTINIC; SIGNAL TRANSDUCTION; TORPEDO; TRANSFECTION; XENOPUS;

EID: 0032582454     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(98)00200-9     Document Type: Article

References (14)

1. Eusebi F., Grassi F., Nervi C., Caporale C., Adamo S., Zani B.M., Molinaro M. Acetylcholine may regulate its own nicotinic receptor-channel through the C-kinase system. Proc. R. Soc. London B. 230:1987;355-365.
2. Exton J.H. Phosphatidylcholine breakdown and signal transduction. Biochim. Biophys. Acta. 1212:1994;26-42.
3. Gehle V.M., Sumikawa K. Site-directed mutagenesis of the conserved N-glycosylation site on the nicotinic acetylcholine receptor subunits. Mol. Brain Res. 11:1991;17-25.
4. Huganir R.L. Regulation of the nicotinic acetylcholine receptor by protein phosphorylation. J. Rec. Res. 7:1987;241-256.
5. Huganir R.L., Greengard P. Regulation of neurotransmitter receptor desensitization by protein phosphorylation. Neuron. 5:1990;555-567.
6. Mishima M., Takai T., Imoto K., Noda M., Takahashi T., Numa S., Methfessel C., Sakmann B. Molecular distinction between fetal and adult forms of muscle acetylcholine receptor. Nature. 321:1986;406-411.
7. 2+ signaling pathway at the endplate provided by the γ to ε subunit switch in ACh receptors. Mol. Brain Res. 24:1994;341-346.
8. Nishizaki T., Sumikawa K. Direct action of 4-β-phorbol-12,13-dibutyrate (PDBu) on nicotinic acetylcholine receptor channel independent of protein kinase C activation. Neurosci. Lett. 188:1995;129-131.
9. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science. 258:1992;607-614.
10. Nishizuka Y. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 9:1995;484-494.
11. Sumikawa K., Miledi R. Assembly and N-glycosylation of all ACh receptor subunits are required for their efficient insertion into plasma membranes. Mol. Brain Res. 5:1989;183-192.
12. Tank D.W., Huganir R.L., Greengard P., Webb W.W. Patch-recorded single-cannel currents of the purified and reconstituted Torpedo acetylcholine receptor. Proc. Natl. Acad. Sci. U.S.A. 80:1983;5129-5133.
13. Tigyi G., Dyer D., Matute C., Miledi R. A serum factor that activates the phosphatidylinositol phosphate signaling system in Xenopus oocytes. Proc. Natl. Acad. Sci. U.S.A. 87:1990;1521-1525.
14. Vijayaraghavan S., Huang B., Blumenthal E.M., Berg D.K. Arachidonic acid as a positive feedback inhibitor of nicotinic acetylcholine receptors in neurons. J. Neurosci. 15:1995;3679-3687.