Changes of neurohumoral parameters and endothelin-1 in response to exercise in patients with mild to moderate congestive heart failure

International Journal of Cardiology

Volumn 66, Issue 2, 1998, Pages 137-142

  Genth Zotz, Sabine ^a   Zotz, Rainer J ^b   Cobaugh, Michael ^a   Van Veldhuisen, Dirk J ^c   Netzer, Tilo ^d   Meyer, Jürgen ^a   Darius, Harald ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF LEIPZIG HEART CENTER   (Germany)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d MERCK KGAA   (Germany)

Author keywords

Endothelin; Exercise capacity; Heart failure; Neurohumoral activation

Indexed keywords

ADRENALIN; ALDOSTERONE; DIPEPTIDYL CARBOXYPEPTIDASE; DOPAMINE; ENDOTHELIN 1; NEUROHORMONE; NORADRENALIN; RENIN;

ADULT; AGED; ARTICLE; BICYCLE ERGOMETRY; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; EXERCISE; FEMALE; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; MAJOR CLINICAL STUDY; MALE; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; VASOCONSTRICTION;

EID: 0032582198     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5273(98)00225-3     Document Type: Article

References (15)

1. [1] Packer M. Neurohormonal interactions and adaptations in congestive heart failure. Circulation 1988;77:721-30.
2. [2] Cohn JN, Levine TB, Olivari MT, Garberg V, Lura D, Francis GS. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. New Engl J Med 1984;311:819-23.
3. [3] Cody RJ, Haas GJ, Binkley PF, Capers Q, Kelly R. Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure. Circulation 1992;85:504-9.
4. [4] Wei CM, Lerman A, Rodeheffer RJ, et al. Endothelin in human congestive heart failure. Circulation 1994;89:1580-6.
5. [5] Omland T, Lie RT, Aakvaag A, Aarsland T, Dickstein K. Plasma endothelin determination as a prognostic indicator of 1-year mortality after acute myocardial infarction. Circulation 1994;89:1573-9.
6. [6] Pousset F, Isnard R, Lechat P, Kalotka H, Carayon A, Maistre G. Prognostic value of plasma endothelin-1 in patients with chronic heart failure. Eur Heart J 1997;18:254-8.
7. [7] Zelis R, Longhurst J, Capone RJ, Mason DT. A comparison of regional blood flow and oxygen utilization during maximal forearm exercise in normal subjects and patients with congestive heart failure. Circulation 1974;50:137-43.
8. [8] Krum H, Goldsmith R, Wilshire-Clement M, Miller M, Packer M. Role of endothelin in the exercise intolerance of chronic heart failure. Am J Cardiol 1995;15:1282-3.
9. [9] De Groote P, Millaire A, Racadot A, Decoulx E, Decloux G. Plasma levels of endothelin-1 at rest and after exercise in patients with moderate congestive heart failure. Int J Cardiol 1995;51:267-72.
10. [10] Maeda S, Miyauchi T, Sakane M, Saito M, Maki S, Goto K, et al. Does endothelin-1 participate in the exercise-induced changes of blood flow distribution of muscles in humans? J Appl Physiol 1997;82(4):1107-11.
11. [11] Francis GS, Goldsmith SR, Levine TB, Olivari MT. The neurohumoral axis in congestive heart failure. Ann Intern Med 1984;101:370-7.
12. [12] Colucci WS. Myocardial endothelin. Does it play a role in myocardial failure? Circulation 1996;93:1069-72.
13. [13] Sakai S, Miyauchi T, Sakurai T, et al. Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure. Marked increase in endothelin-1 production in the failing heart. Circulation 1996;93(6):1214-22.
14. [14] McMurray JJ, Ray SG, Abdullah I, Dargie HJ, Morton JJ. Plasma endothelin in chronic heart failure. Circulation 1992;85:1374-9.
15. [15] Hiroe M, Hirata Y, Fujita, et al. Plasma endothelin-1 levels in dilated cardiomyopathy. Am J Cardiol 1991;68:1114-5.