Endoplasmic reticulum retention and degradation of T cell antigen receptor β chain

Experimental and Molecular Medicine

Volumn 30, Issue 3, 1998, Pages 159-164

  Lee, Song Jae ^a  

^a Kosin University College of Medicine   (South Korea)

Author keywords

Endoplasmic reticulum (ER); T cell antigen receptor(TCR)

Indexed keywords

CD3 ANTIGEN; MUTANT PROTEIN; T LYMPHOCYTE RECEPTOR; TYROSINE;

AMINO ACID SEQUENCE; ARTICLE; BETA CHAIN; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GLYCOSYLATION; HELA CELL; HOMEOSTASIS; HUMAN; HUMAN CELL; PROTEIN DEGRADATION;

EID: 0032582067     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.1998.23     Document Type: Article

References (6)

1. Baranski, T. J., Faust, P. L. and Kornfeld, S. (1990) Generation of a lysosomal enzyme targeting signal in the secretory protein pepsinogen. Cell 63: 281-291
2. Beggah, A., Mathews, P., Beguin, P. and Geering, K. (1996) Degradation and endoplasmic reticulum retention of unassembled alpha- and beta-subunits of Na,K-ATPase correlate with interaction of BiP. J. Biol. Chem. 271: 20895-20902
3. Blumberg, R. S., Alarcon, B., Sancho, J., Mcdermott, F. V., Lopez, P., Breitmyer, J. and Terhorst, C. (1990) Assembly and function of the T cell antigen receptor requirement of either the lysine or arginine residues in the transmembrane region of the a chain. J. Biol. Chem. 265: 14036-14043
4. Bonifacino, J. S., Suzuki, C. K., Lippincott-Schwartz, J., Weissman, A. M. and Klausner, R. D. (1989) Pre-Golgi degradation of newly synthesized T cell antigen receptor chains: intrinsic sensitivity and the role of subunit assembly. J. Cell. Biol. 109: 73-83
5. Bonifacino, J. S.,Cosson, P. and Klausner, R. D. (1990a) Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains. Cell 63: 503-513
6. Bonifacino, J. S., Suzuki, C. K. and Klausner, R. D. (1990b) A peptide sequence confers retention and rapid degradation in the endoplasmic reticulum. Science 247: 79-82