The Involvement of Nitric Oxide in Synergistic Neuronal Damage Induced by β-amyloid Peptide and Glutamate in Primary Rat Cortical Neurons

Chinese Journal of Physiology

Volumn 41, Issue 3, 1998, Pages 175-179

  Yang, San Nan ^a   Hsieh, Wen Yia ^a   Liu, Demeral David ^a   Tsai, Lih Min ^a   Tung, Che Se ^a   Wu, Jian Nan ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Alzheimer's disease; Glutamate; Neurodegeneration; Nitric oxide; amyloid peptide

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (25 35); AMYLOID BETA-PROTEIN (25-35); ENZYME INHIBITOR; GLUTAMIC ACID; LACTATE DEHYDROGENASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; ANIMAL; ARTICLE; BRAIN CORTEX; CELL CULTURE; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; METABOLISM; NERVE CELL; NERVE DEGENERATION; RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; DRUG SYNERGISM; ENZYME INHIBITORS; GLUTAMIC ACID; L-LACTATE DEHYDROGENASE; NERVE DEGENERATION; NEURONS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; PEPTIDE FRAGMENTS; RATS;

EID: 0032581889     PISSN: 03044920     EISSN: 26660059     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Belvisi, M.G., D. Stretton, and P.J. Barnes. Nitric oxide as an endogenous modulator of cholinergic neurotransmission in guineapig airways. Eur. J. Pharmacol. 198: 219-221, 1991.
2. Choi, D.W., M.A. Maulucci-gedde, and A.R. Kriegstein. Glutamate neurotoxicity in cortical cell culture. J. Neurosci. 7: 357-368, 1987.
3. Dawson, V.L., T.M. Dawson, D.A. Bartley, G.R. Uhl, and S.H. Snyder. Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J. Neurosci. 13: 2651-2661, 1993.
4. Dawson, V.L., T.M. Dawson, E.D. London, D.S. Bredt, and S.H. Snyder. Nitric oxide mediates glutamate neurotoxicity in primary cortical culture. Proc. Natl. Acad. Sci. USA 88: 6368-6371, 1991.
5. Gray, C.W., and A.J. Patel. Neurodegeneration mediated by glutamate and β-amyloid peptide: a comparison and possible interaction. Brain Res. 691: 169-179, 1995.
6. 15 N-nitrite in biological fluids. Anal. Biochem. 126: 131-138, 1982.
7. Hensley, H., G.M. Carney, M.P. Mattson, M. Aksenova, M. Harris, J.F. Wu, R.A. Floyd, and D.A. Butterfield. A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer's disease. Proc. Natl. Acad. Sci. USA 91: 3270-3274, 1994.
8. Hewett, S.J., C.A. Csernansky, and D.W. Choi. Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS. Neuron 13:487-494, 1994.
9. Hibbs, J.B., R.R. Taintor, Z. Vavrin, and E.M. Rachlin. Nitric oxide: acytotoxic activated macrophage effector molecule. Biochem. Biophys. Res. Commun. 157: 87-94, 1988.
10. Koh, J.Y., L.L. Yang, and C.W. Cotman. β-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res. 533: 315-320, 1990.
11. Le, W.D., L.V. Colom, W.J. Xie, R.G. Smith, M. Alexianu, and S.H. Appel. Cell death induced by beta-amyloid 1-40 in MES 23.5 hybrid clone: the role of nitric oxide and NMDA-gated channel activation leading to apoptosis. Brain Res. 686: 49-60, 1995.
12. Liu, D.M., J.N. Wu, A.L. Chiou, J.Y. Liu, and Y. Wang. NMDA induces NO release from primary cell cultures of human cerebral cortex. Neurosci. Lett. 223: 145-148, 1997.
13. Mattson, M.P., B. Cheng, D. Davis, K. Bryant, I. Liebergurg, and R.E. Rydel. β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12: 376-389, 1992.
14. Meda, L., M.A. Cassatella, G.I. Szendrei, L. Otvos, P. Baron, M. Villalba, D. Ferrari, and F. Rossi. Activation of microglia cells by β-amyloid protein and interferon-ρ. Nature 374: 647-650, 1995.
15. Moore, P.K., R.C. Babbedge, P. Wallace, Z.A. Gaffen, and S.L. Hart. 7-Nitroidazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br. J. Pharmacol. 108: 296-297, 1993.
16. O'Dell, T.J., R.D. Hawkins, E.R. Kandel, O. Arancia. Tests of the roles of two diffusible substances in LTP: evidence for nitric oxide as a possible early retrograde messenger. Proc. Natl. Acad. Sci. USA 88: 11285-11289, 1991.
17. Rossi, F., and E. Bianchini. Synergistic induction of nitric oxide by β-amyloid and cytokines in astrocytes. Biochem. Biophys. Res. Commun. 225: 474-478, 1996.
18. Selkoe, D.J. Normal and abnormal biology of the β-amyloid precursor protein. Annu. Rev. Neurosci. 17: 489-517, 1994.
19. Wolff, D.J., and A. Lubeskie. Aminoguanidine is an isoform selective, mechanism based inactivator of nitric oxide synthase. Arch. Biochem. Biophys. 316, 290-301, 1995.
20. Zhang, J., V.L. Dawson, T.M. Dawson, and S.H. Snyder. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science 263: 87-689, 1994.