In Vivo chiro-Inositol Metabolism in the Rat: A Defect in chiro-Inositol Synthesis from myo-Inositol and an Increased Incorporation of chiro-[3H]Inositol into Phospholipid in the Goto-Kakizaki (G.K.) Rat

Molecules and Cells

Volumn 8, Issue 3, 1998, Pages 301-309

  Pak, Yunbae ^c   Hong, Yonggeun ^c   Kim, Seokyong ^c   Piccariello, Tom ^a   Farese, Robert V ^b   Larner, Joseph ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c Gyeongsang National University   (South Korea)

Author keywords

Chiro inositol; G.K. Rats; Non insulin dependent diabetes mellitus; Phospholipid

Indexed keywords

DIAGNOSTIC AGENT; DRUG DERIVATIVE; INOSITOL; INOSITOL PHOSPHATE; PHOSPHATIDYLINOSITOL; PHOSPHOLIPID; TRITIUM;

ANIMAL; ARTICLE; CHEMISTRY; MALE; METABOLISM; RAT; RAT STRAIN; THIN LAYER CHROMATOGRAPHY; TISSUE DISTRIBUTION; WISTAR RAT;

ANIMALS; CHROMATOGRAPHY, THIN LAYER; INOSITOL; INOSITOL PHOSPHATES; MALE; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPIDS; RATS; RATS, INBRED STRAINS; RATS, WISTAR; TISSUE DISTRIBUTION; TRITIUM;

EID: 0032580846     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Abe, S., Huang, L. C., and Larner, J. (1996) Dephosphorylation of PDH by phosphoprotein phosphatases and its allosteric regulation by inositol glycans: in Alpha-keto Acid Dehydrogenase Complexes, (Patel, M. S., Roach, T. E., and Harris, R. A. (eds.), pp. 187-195, Birkhauser Verlag Basel/Switzerland.
2. Akiyama, T., Takechi, N., Ozaki, S., and Shiota, K. (1992) A chiral synthesis of D-myo-inositol 1-phosphate starting from L-quebrachitol. Bull. Chem. Soc. (Jpn) 65, 366-372.
3. Asplin, I., Galasko, G., and Larner, J. (1993) Chiroinositol deficiency and insulin resistance: A comparison of the chiro-inositol- and the myo-inositol-containing insulin mediators isolated from urine, hemodialysate, and muscle of control and type II diabetic subjects. Proc. Natl. Acad. Sci. USA 90, 5924-5928.
4. Bogardus, C., Lillioja, S., Howard, B. V., Reaven, G., and Mott, D. (1984) Relationship between insulin secretion, insulin action and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects. J. Clin. Invest. 74, 1238-1246.
5. Craig, J. W., Larner, J., and Asplin, C. M. (1994) Chiroinositol deficiency and insulin resistance, in Molecular Biology of Diabetes, Draznin, B. and Le Roith, D. (eds.), pp. 343-362, Humana Press, Totowa, NJ.
6. Farese, R. V., Standaert, M. L., Yamada, K., Huang, L. C., Zhang, C., Cooper, D. R., Wang, Z., Tang, Y., Suzuki, S., Toyota, T., and Larner, J. (1994) Insulin-induced activation of glycerol-3-phosphate acyltransferase by a chiro-inositol-containing insulin mediator is defective in adipocytes of insulin-resistant, type II diabetic, Goto-Kakizaki rats. Proc. Natl. Acad. Sci. USA 91, 11040-11044.
7. Fonteles, M. C., Huang, L. C., and Larner, J. (1996) Infusion of pH 2.0 D-chiro-inositol glycan insulin putative mediator normalizes plasma glucose in streptozotocin diabetic rats at a dose equivalent to insulin without inducing hypoglycaemia. Diabetologia 39, 731-734.
8. + epimerase and inosose: NAD(P)H reductase from the body fat of American cockroach. Periplaneta Americana L. Biochemistry 12, 4705-4712.
9. Kennington, A. S., Hill, C. R., Craig, J., Bogardus, C., Raz. I., Ortmeyer. H. K., Hansen, B. C., Romero, G., and Larner, J. (1990) Low urinary Chiroinositol excretion in non-insulin dependent diabetes mellitus. New Eng. J. Med. 323, 373-378.
10. Krakow, J. L., Doering, T. L., Masterson, W. J., Hart, G. W., and England, P. T. (1989) A glycolipid from Trypanosoma brucei related to the variant surface glycoprotein membrane anchor. Molecular and Biochemical Parasitology 36, 263-270.
11. Krakow, J. L., Hereld, D., Bands, J. D., Hart, G. W., and England, P. T. (1986) Identification of a glycolipid precursor of the Trypanosoma brucei variant surface glycoprotein. J. Biol. Chem. 261, 12147-12153.
12. Lamer, J., Galasko, G., Cheng, K., DePaoli-Roach, A. A., Huang, L., Daggy, P., and Kellog, J. (1979) Generation by insulin of a chemical mediator that controls protein phosphorylation and dephosphorylation. Science 206, 1408-1410.
13. Larner, J., Huang, L. C., Schwartz, C. F. W., Oswald, A. S., Shen, T. Y., Kinter, M., Tang, G., and Zeller, K. (1988) Rat liver insulin mediator which stimulates pyruvate dehydrogenase phosphatase contains galactosamine and D-chiroinositol. Biochem. Biophys. Res. Commun. 151, 1416-1426.
14. Lamer, J., Huang, L. C., Suzuki, S., Tang, G., Zhang, C., Schwartz, C. F. W., Romero, G., Luttrell, L., and Kennington, A. S. (1989) Insulin mediators and the control of pyruvate dehydrogenase. Ann. N.Y. Acad. Sci. 573, 297-305.
15. Mandarino, L. J., Wright, K. S., Vintz, L. S., Nichols, J., Bell, J. M., Kolterman, O. G., Beck-Nielson, H. (1987) Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase and glycogen synthase. Evidence for their role in non-oxidative and oxidative glucose metabolism. J. Clin. Invest. 80, 655-663.
16. Ohneda, M., Johnson. J. H., Inman. L. R., Chen. L., Suzuki. K., Goto, Y., Alam, T., Ravazzola, M., Orci, L., and Unger, R. H. (1993) GLUT2 expression and function in β-cells of GK rats with NIDDM. Diabetes 42, 1065-1072.
17. Ortmeyer, H. K., Bodkin, N. L., Lilley, K., Larner, J., and Hansen, B. C. (1993) Chiroinositol deficiency and insulin resistance. I. Urinary excretion rate of chiroinositol is directly associated with insulin resistance in spontaneous diabetic rhesus monkeys. Endocrinol. 132, 640-645.
18. 3H)inositol. J. Biol. Chetn. 271, 10073-10078.
19. Pak, Y. and Larner, J. (1992) Identification and characterization of chiroinositol-containing phospholipids from bovine liver. Biochem. Biophys. Res. Commun. 184, 1042-1047.
20. 3H]chiroinositol in rat tissues. J. Biol. Chem. 267, 16904-16910.
21. Pak, Y. Paule, C. R., Bao, Y-D., Huang, L. C. and Larner, J. (1993) Insulin stimulates the biosynthesis of chiroinositol-containing phospholipids in a rat fibroblast line expressing the human insulin receptor. Proc. Natl. Acad. Sci. USA 90, 7759-7763.
22. Parpal, S., Gustavsson, J., and Stralfors, P. (1995) Isolation of phosphooligosaccharide/phosphoinositol glycan from caveolae and cytosol of insulin-stimulated cells. J. Cell Biol. 131, 125-135.
23. Paulsen, H., von Deyn, W., and Roben, W. (1994) Synthese von enantiomerenreiner pseudo-α-D-galactopyranose und pseudo-β-D-mammopyranose. Liebigs Ann. Chem. 433-449.
24. Portha, B., Serradas, P., Baibe, D., Suzuki, K-I., Goto, Y., and Giroix. M. H. (1991) β-Cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes. Diabetes 40, 486-491.
25. Reaven, G. R. (1988) Role of insulin resistance in human disease. Diabetes 37, 1595-1607.
26. Saltiel, A. R. and Cuatrecasas, P. (1986) Insulin stimulates the generation from hepatic plasma membranes of modulators derived from an inositol glycolipid. Proc. Natl. Acad. Sci. USA 83, 5793-5797.
27. Sanchez-Gutierrez, J. C., Sanchez-Arias, J. A., Valle, J. C., Guadano, A., Samper, B., Mato, J. M., and Feliu, J. E. (1994) Insulin resistance in genetically obese (fa/fa) rats: changes in the glycosyl-phosphatidylinositol signalling system in isolated hepatocytes. Endocrinology 134, 1485-1492.
28. Schwartz, C. F. W., Villar-Palasi, C., Malchoff, C., and Larner, J. (1988) Isolation and characterization of insulin mediators; in Insulin Receptors, Part B: Clinical assessment, biological responses, and comparison to the IGF-I receptor, Kahn, C. R. (ed.), pp. 155-170, Alan R. Liss, Inc.
29. Sener, A., Malaisse-Lagae, F., Ostenson. C-G., and Malaisse, W. J. (1993) Metabolism of endogenous nutrients in islets of Goto-Kakizaki (GK) rats. Biochem. J. 296, 329-334.
30. Shafrir, E. (1992) Animal models of non-insulin-dependent diabetes. Diabetes Metabolism Rev. 8, 179-208.
31. Snedecor, G. W. and Cochran, W. G. (1980) Statistical Methods. 7th Ed., Iowa State University Press, Ames, Iowa.
32. Suzuki, S., Kawasaki, H., Satoh, Y., Ohtomo, M., Hirai, M., Hirai, A., Hirai, S., Onoda, M., Matsumoto, M., Hinokio, Y., Akai, Y., Craig, J., Larner, J., and Toyota, T. (1994) Urinary chiro-inositol excretion is an index marker of insulin sensitivity in Japanese Type II diabetes. Diabetes Care 17, 1465-1468.
33. Suzuki S., Taneda, Y, Hirai, S., Abe, S., Sasaki, A., Suzuki, K.-I., and Toyota, T. (1991) Molecular mechanism of insulin resistance in spontaneous diabetic GK (Goto-Kakizaki) rats; in New Directions in Research and Clinical Works for Obesity and Diabetes Mellitus, Sakamoto, N., Angel, A., and Hotta, N. (eds.), pp. 197-203, Elsevier Science, New York.
34. Vaag, A., Heinrickson, J. E., and Beck-Nielson, H. (1992) Defect in insulin activation of glycogen synthase in skeletal muscle in first degree relatives to patients with type II (non-insulin dependent) diabetes mellitus. J. Clin. Invest. 89, 782-788.
35. Villa-Palasi, C. and Farese, R. V. (1994) Impaired skeletal muscle glycogen synthase activation by insulin in the Goto-Kakizaki (GK) rat. Diabetologia 37, 885-888.
36. Warram, J. H., Martin, B. C., Krolewski, A. S., Soeldner, J. S., and Kahn, C. R. (1990) Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in offspring of diabetic parents. Ann. Intern. Med. 113, 909-915.
37. Wober, G. and Hoffmann-Ostenhof, O. (1969) Untersuchungen uber die Biosynthese der Cyclite, 22. Mitt.: Cyclite in Chlorella fusa. Monatsh. Chem. 100, 369-375.
38. Yagihashi, S., Tonosaki, A., Yamada, K.-I., Kakizaki, M., and Goto, Y. (1982) Peripheral neuropathy in selectively-inbred spontaneously diabetic rats: electrophysiologica), morphometrical and freeze-replica studies. Tohoku J. Exp. Med. 138, 39-48.