31P NMR spectroscopy detects metabolic abnormalities in asymptomatic patients with hypertrophic cardiomyopathy

Circulation

Volumn 97, Issue 25, 1998, Pages 2536-2542

  Jung, Wulf Ingo ^a   Sieverding, Ludger ^b   Breuer, Johannes ^b   Hoess, Thomas ^a   Widmaier, Stefan ^a   Schmidt, Oliver ^b   Bunse, Michael ^a   Van Erckelens, Franz ^a   Apitz, Jürgen ^b   Lutz, Otto ^b   Dietze, Guenther J ^a  

^a Max Grundig Clinic   (Germany)

^b NONE

Author keywords

Cardiomyopathy; Ischemia; Metabolism

Indexed keywords

PHOSPHATE; PHOSPHORUS;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; FEMALE; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; STATISTICAL ANALYSIS; SYMPTOMATOLOGY; CASE CONTROL STUDY; CHILD; HEART MUSCLE; METABOLISM; METHODOLOGY;

ADOLESCENT; ADULT; CARDIOMYOPATHY, HYPERTROPHIC; CASE-CONTROL STUDIES; CHILD; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIUM; PHOSPHORUS ISOTOPES;

EID: 0032580792     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.97.25.2536     Document Type: Article

References (43)

1. Maron BJ. Hypertrophic cardiomyopathy. Curr Prob Cardiol. 1993;18:639-704.
2. McKenna WJ, Stewart JT, Nihoyannopoulus P, McGinty F, Davies MJ. Hypertrophic cardiomyopathy without hypertrophy: two families with myocardial disarray in the absence of increased myocardial mass. Br Heart J. 1990;63:287-290.
3. Jarcho JA, McKenna W, Pare JAP, Solomon SD, Holcombe RF, Dickies S, Levi T, Donis-Keller H, Seidman JG, Seidman CE. Mapping a gene for familial hypertrophic cardiomyopathy to chromosome 14q1. N Engl J Med. 1989;321:1372-1378.
4. Roberts R. Molecular genetics: therapy or terror? Circulation. 1994;89:499-502.
5. Wagner JA, Sax FL, Weisman HF, Porterfield J, McIntosh C, Weisfeldt ML, Snyder SH. Epstein SE. Calcium-antagonist receptors in the atrial tissue of patients with hypertrophic cardiomyopathy. N Engl J Med. 1989;320:755-761.
6. Brush JE Jr, Eisenhofer G, Garty M, Stull R, Maron BJ, Cannon RO III, Panza JA, Epstein SE, Goldstein DS. Cardiac norepinephrine kinetics in hypertrophic cardiomyopathy. Circulation. 1989;79:836-844.
7. Maron BJ, Epstein SE, Roberts WC. Hypertrophic cardiomyopathy and transmural myocardial infarction without significant atherosclerosis of the extramural coronary arteries. Am J Cardiol. 1979;43:1086-1102.
8. McKenna WJ, Camm AJ. Sudden death in hypertrophic cardiomyopathy: assessment of patients at high risk. Circulation. 1989;80:1489-1492.
9. Drory Y, Turetz Y, Hiss Y, Lev B, Fisman EZ, Pines A, Kramer MR. Sudden unexpected death in persons <40 years of age. Am J Cardiol. 1991;68:1388-1392.
10. Romeo F, Pelliccia F, Cristofani R, Martuscelli E, Reale A. Hypertrophic cardiomyopathy: is left ventricular outflow tract gradient a major prognostic determinant? Eur Heart J. 1990;11:233-240.
11. O'Gara PT, Bonow RO, Maron BJ, Damske BA, van Lingen A, Bacharach SL, Larson SM, Epstein SE. Myocardial perfusion abnormalities in patients with hypertrophic cardiomyopathy: assessment with thallium-201 emission computed tomography. Circulation. 1987;76:1214-1223.
12. Camici P, Chiaretti G, Lorenzoni R, Bellina RC, Gistri R, Italiani G, Parodi O, Salvadori PA, Nista N, Papi L, L'Abbate A. Coronary vasodilatation is impaired in both hypertrophied and non-hypertrophied myocardium of patients with hypertrophic cardiomyopathy: a study with nitrogen-13 ammonia and positron tomography. J Am Coll Cardiol. 1991;17:879-886.
13. Nienaber CA. Gambhir SS, Mody FV, Ratib O, Huang SC, Phelps ME, Schelbert HR. Regional myocardial blood flow and glucose utilization in symptomatic patients with hypertrophic cardiomyopathy. Circulation. 1993;87:1580-1590.
14. Perrone-Filardi P, Bacharach SL, Dilsizian V, Panza JA, Maurera S, Bonow RO. Regional systolic function, myocardial blood flow and glucose uptake at rest in hypertrophic cardiomyopathy. Am J Cardiol. 1993;72:199-204.
15. Bottomley PA, Herfkens RJ, Smith LS, Bashore TM. Altered phosphate metabolism in myocardial infarction: P-31 NMR spectroscopy. Radiology. 1987;165:703-707.
16. Weiss RG, Bottomley PA, Hardy CJ, Gerstenblith G. Regional myocardial metabolism of high-energy phosphates during isometric exercise in patients with coronary artery disease. N Engl J Med. 1990;323:1593-1600.
17. Schaefer S, Gober JR, Schwartz GG, Twieg DB, Weiner MW, Massie B. In vivo phosphorus-31 spectroscopic imaging in patients with global myocardial disease. Am J Cardiol. 1990;65:1154-1161.
18. 31P magnetic resonance spectroscopy. Lancet. 1991;338:973-976.
19. 31P magnetic resonance spectroscopy in dilated cardiomyopathy and coronary artery disease. Circulation. 1992;86:1810-1818.
20. de Roos A, Doornbos J, Luyten PR, Oosterwaal LJMP, van der Wall EE, den Hollander JA. Cardiac metabolism in patients with dilated and hypertrophic cardiomyopathy: assessment with proton-decoupled P-31 MR spectroscopy. J Magn Reson Imaging. 1992;2:711-719.
21. 31P magnetic resonance spectroscopy during handgrip exercise. Circulation. 1994;89:1709-1716.
22. Jung WI, Widmaier S, Seeger U, Bunse M, Staubert A, Sieverding L, Straubinger K, van Erckelens F, Schick F, Dietze G, Lutz O. Phosphorus J-coupling constants of ATP in human myocardium and calf muscle. J Magn Reson B. 1996;110:39-46.
23. 31P-NMR spectroscopy of human blood and serum: first results from volunteers and patients with congestive heart failure, diabetes mellitus and hyperlipidaemia. MAGMA. 1993;1:55-60.
24. 31P NMR signals using the variable projection method and prior knowledge. Magn Reson Med. 1988;6:92-98.
25. 1 values. Magn Reson Med. 1994;32:137-141.
26. Noggle JH, Schirmer RE. The Nuclear Overhauser Effect. New York. NY: Academic Press; 1971.
27. 31P nuclear magnetic resonance spectroscopy. Neurology. 1985;35:781-788.
28. Bunse M, Jung WI, Lutz O, Küper K, Dietze G. Polarization-transfer effects in localized double-spin-echo spectroscopy of weakly coupled homonuclear spin systems. J Magn Reson A. 1995;114:230-237.
29. 31P magnetic resonance spectroscopy of the Sherpa heart: a phosphocreatine/adenosine triphosphate signature of metabolic defense against hypobaric hypoxia. Proc Natl Acad Sci U S A. 1996;93:1215-1220.
30. Betocchi S, Hess OM, Losi MA, Nonogi H, Krayenbuehl HP. Regional left ventricular mechanics in hypertrophic cardiomyopathy. Circulation. 1993;88:2206-2214.
31. Goodwin GW, Ahmad F, Taegtmeyer H. Preferential oxidation of glycogen in isolated working rat heart. J Clin Invest. 1996;97:1409-1416.
32. Jeffrey FMH, Storey CJ, Malloy CR. Predicting functional recovery from ischemia in the rat myocardium. Basic Res Cardiol. 1992;87:548-538.
33. Balaban RS. Regulation of oxidative phosphorylation in the mammalian cell. Am J Physiol. 1990;258:C377-C389.
34. Conway MA, Bristow JD, Blackledge MJ, Rajagopalan B, Radda GK. Cardiac metabolism during exercise measured by magnetic resonance spectroscopy. Lancet. 1988;2:692.
35. Schaefer S, Schwartz GG, Gober JR, Wong AK, Camacho SA, Massie B, Weiner MW. Relationship between myocardial metabolites and contractile abnormalities during graded regional ischemia. J Clin Invest. 1990;85:706-713.
36. Arai AE, Grauer SE, Anselone CG, Pantely GA, Bristow D. Metabolic adaption to a gradual reduction in myocardial blood flow. Circulation. 1995;92:224-252.
37. Allard MF, Henning SL, Wambolt RB, Granleese SR, English DR, Lopaschuk GD. Glycogen metabolism in the aerobic hypertrophied rat heart. Circulation. 1997;96:676-682.
38. Zhang J, Merkle H, Hendrich K, Garwood M, From AHL, Ugurbil K, Bache RJ. Bioenergetic abnormalities associated with severe left ventricular hypertrophy. J Clin Invest. 1993;92:993-1003.
39. Holden JE, Stone CK, Clark CM, Brown WD, Nickles RJ, Stanley C, Hochachka PW. Enhanced cardiac metabolism of plasma glucose in high-altitude natives: adaptation against chronic hypoxia. J Appl Physiol. 1995;79:222-228.
40. Taegtmeyer H. Myocardial metabolism. In: Phelps M, Mazziotta J, Schelbert H, eds. Positron Emission Tomography: Principles and Applications for Brain and Heart. New York, NY: Raven Press; 1986:149-195.
41. Chance B, Leigh JS Jr, Clark BJ, Maris J, Kent J, Nioka S, Smith D. Control of oxidative phosphorylation and oxygen delivery in human skeletal muscle: a steady-state analysis of work/energy cost transfer function. Proc Natl Acad Sci U S A. 1985;82:8384-8388.
42. Zhang J, Zhang Y, Murakami Y, From AH, Ugurbil K, Bache RJ. Myocardial oxygenation and bioenergetics at high work states in hearts with left ventricular hypertrophy. Circulation. 1997;96(suppl I):I-1413. Abstract.
43. Braunwald E. Induced septal infarction: a new therapeutic strategy for hypertrophic nonobstructive cardiomyopathy. Circulation. 1997;95:1981-1982.