A new convenient synthesis of bifunctional chelating agent 1-(4- aminobenzyl)-1,4,8,11-tetraazacyclotetradecane-N',N'',N'''-triacetic acid [1- (H2NBn-TETA)]

Tetrahedron Letters

Volumn 39, Issue 18, 1998, Pages 2659-2662

  Maillet, M ^a   Kwok, C S ^b   Noujaim, A A ^c   Snieckus, V ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

^b JURAVINSKI CANCER CENTRE   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 AMINOBENZYL) 1,4,8,11 TETRAAZACYCLOTETRADECANE N',N'',N''' TRIACETIC ACID; CHELATING AGENT; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS;

EID: 0032580321     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00372-4     Document Type: Article

References (15)

1. 1. DeNardo S.J.; DeNardo, G.L.; Peng, J.-S.; Colcher, D. Monoclonal Antibody Radiopharmaceuticals of Cancer . Radioimmunotherapy. Radioimaging and Radioimmunotherapy; DeNardo S.J.; DeNardo, G.L.; Peng, J.-S.; Colcher, D.; Ed.; Elsevier : New York, 1983, p 409.
2. 2. Parker, D.; Jankowski, K. J. In Advances in Metals in Medicine; Murrer, B. A., Abrams, M. J., Eds.; Jai Press: New York, 1993; Vol. 1, p 29.
3. 3. Bernard, H.; Yaouanc, J.J.; Clement, J.C.; des Abbayes, H.; Handel, H. Tetrahedron Lett. 1991, 32, 629.
4. 4. Filali, A.; Yaouanc, J-J.; Handel, H. Angew. Chem. Int. Ed. Engl. 1991, 30, 560.
5. 5. Patinec, V., Yaouanc, J.-J.; Clément, J.C.; Handel, H., des Abbayes, H. Tetrahedron Lett. 1995, 36, 79.
6. 6. McMurry, T. J.; Brechbiel, M.; Kumar, K.; Gansow, O. A. Bioconjugate Chem. 1992, 3, 108.
7. 7. Ruser, G.; Ritter, W.; Maecke, H. R. Bioconjugate Chem. 1990, 1, 345.
8. 8. Moran, J. K.; Greinet, D. F., Meares, C. F. Bioconjugate Chem. 1995, 6, 296.
9. 9. Helps, I.M.; Parker, D.; Morphy, J.R.; Chapman. J. Tetrahedron Lett. 1989, 45, 219.
10. 10. Mishra, A.K.; Draillard, K.; Faivre-Chauvet, A.; Gestin, J.-F.; Curtet, C.; Chatal, J.-F. Tetrahedron Lett. 1996, 37, 7515.
11. 11. Moreau, P.; Tinkl, M.; Tsukazaki, M.; Bury, P.S., Griffen, E.J.; Snieckus, V.; Maharajh, R.B.; Kwok, C.S.; Somayaji, V.V.; Peng Z.; Sykes, T.R.; Noujaim, A.A. Synthesis, 1997, 1010.
12. 12. SET reactions may be operating, sec Houge-Frydrych, C.S.V.; Motherwell, W.B.; O'Shea, D.M. J.C.S. Chem. Commun. 1987, 1819 and refs cited therein.
13. 9 mp 31-33°C which was used directly in the next step.
14. 3) δ 24.97, 25.29, 51.09, 51.28, 51.44, 55.29, 58.47, 65.94, 123.28, 128.24, 128.49, 129.28, 135.70, 135.82,146.89, 148.25, 171.21, 171.33. FABMS m/z 780.7 (M + H) 100%
15. 6: 477.25873 , found 477.25478.