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To which extent these concepts, which are based on simple, low-molecular weight model compounds, whose intramolecular motions are not restricted, can be applied to the rather stiff DNA polymer remains to be seen. It is obvious that model calculations on H-transfer to phosphate radicals at C3′ or C5′ from "adjacent" deoxyribose C-H groups would be very helpful.
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The authors, however, propose a different mechanism.
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2642613260
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In the case of DNA, neutral phosphate radicals are expected from the DNA monoanionic phosphate ester function. These neutral radicals should be considerably more oxidizing (i.e., even better H-abstractors) than the phosphato radical anions discussed in this paper.
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