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Volumn 120, Issue 16, 1998, Pages 3928-3934

Photoionization of organic phosphates by 193 nm laser light in aqueous solution: Rapid intramolecular H-transfer to the primarily formed phosphate radical. A model for ionization-induced chain-breakage in DNA?

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DNA STRAND BREAKAGE; IONIZATION; OXIDATION REDUCTION REACTION; PHOTOLYSIS; RADIATION INJURY; RADIATION MUTAGENESIS; REACTION ANALYSIS;

EID: 0032577050     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja974393m     Document Type: Article
Times cited : (44)

References (57)
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    • note
    • •.
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    • •2-.
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    • note
    • To which extent these concepts, which are based on simple, low-molecular weight model compounds, whose intramolecular motions are not restricted, can be applied to the rather stiff DNA polymer remains to be seen. It is obvious that model calculations on H-transfer to phosphate radicals at C3′ or C5′ from "adjacent" deoxyribose C-H groups would be very helpful.
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    • note
    • The authors, however, propose a different mechanism.
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    • note
    • In the case of DNA, neutral phosphate radicals are expected from the DNA monoanionic phosphate ester function. These neutral radicals should be considerably more oxidizing (i.e., even better H-abstractors) than the phosphato radical anions discussed in this paper.


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