cis-[PtCl2(4,7-H-5-methyl-7-oxo[1,2,4]triazolo[1,5-a]pyrimidine)2]: A sterically restrictive new cisplatin analogue. Reaction kinetics with model nucleobases, DNA interaction studies, antitumor activity, and structure - Activity relationships

Journal of Medicinal Chemistry

Volumn 41, Issue 3, 1998, Pages 332-338

  Navarro, Jorge A R ^a   Salas, Juan M ^a   Romero, M Angustias ^a   Vilaplana, Rosario ^b   Gonzalez Vflchez, Francisco ^b   Faure, Rene ^c  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

^c UNIVERSITÉ LYON 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; ANTINEOPLASTIC AGENT; CIS DICHLOROBIS(4,7 H 5 METHYL 7 OXO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE)PLATINUM; CISPLATIN DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; (PTCL2(4,7 H 5 METHYL 7 OXO(1,2,4)TRIAZOLO(1,5 A)PYRIMIDINE)2); (PTCL2(4,7-H-5-METHYL-7-OXO(1,2,4)TRIAZOLO(1,5-A)PYRIMIDINE)2); CISPLATIN; DNA; DRUG DERIVATIVE; PLATINUM COMPLEX;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; DRUG DNA INTERACTION; DRUG FORMULATION; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; OVARY CARCINOMA; STRUCTURE ACTIVITY RELATION; CELL CULTURE; CELL DIVISION; CHEMICAL MODEL; CHEMISTRY; DRUG EFFECT; KINETICS; SPECTROSCOPY;

ANTINEOPLASTIC AGENTS; CELL DIVISION; CISPLATIN; DNA; HUMANS; KINETICS; MODELS, CHEMICAL; ORGANOPLATINUM COMPOUNDS; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0032576634     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970358e     Document Type: Article

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