Alzheimer changes are common in aged drivers killed in single car crashes and at intersections

Forensic Science International

Volumn 96, Issue 2-3, 1998, Pages 115-127

  Viitanen, Matti ^a   Johansson, Kurt ^a   Bogdanovic, Nenad ^a   Berkowicz, Adam ^b   Druid, Henrik ^c   Eriksson, Anders ^d   Krantz, Peter ^b   Laaksonen, Hannu ^e   Sandler, Håkan ^f   Saukko, Pekka ^e   Thiblin, Ingemar ^a   Winblad, Bengt ^a   Kalimo, Hannu ^a,g  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Department of Forensic Medicine ^*  (Sweden)

^c LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^d UMEÅ UNIVERSITY   (Sweden)

^e UNIVERSITY OF TURKU   (Finland)

^f UPPSALA UNIVERSITY   (Sweden)

^g TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Alzheimer's disease; Beta amyloid; Fatal car accident; Neuropathology

Indexed keywords

AMYLOID BETA PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; DRIVER; FATALITY; FEMALE; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; MALE; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; PARIETAL LOBE; PRIORITY JOURNAL; SENILE PLAQUE; TRAFFIC ACCIDENT;

EID: 0032575954     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0379-0738(98)00114-5     Document Type: Article

References (35)

1. E. Cerelli, Older drivers, the age factor in traffic safety. NHTSA Technical Report DOTHS 807 402. National Highway Safety Administration, 1989.
2. P.C. Dischinger, J.H. Siegel, K.M. Read, S. Mason-Gonzalez, The role of medical conditions in high speed crashes. Proceedings 37th Annual Conference of Association for Advancement of Automotive Medicine, 1993, pp. 423-424.
3. B.J. Peterson, C.S. Petty, Sudden natural death among automobile drivers, J. Forensic Sci. 7 (1962) 274-285.
4. H. Sjögren, A. Eriksson, M. Öström, Role of disease in initiating the crashes of fatally injured drivers, Accid. Anal. Prey. 28 (1996) 307-314.
5. D.A. Drachman, J.M. Swearer, and the Collaborative Study Group, Driving and Alzheimer's disease: the risk of crashes. Neurology 43 (1993) 2448-2456.
6. R.P. Friedland, E. Koss, A. Kumar, et al., Motor vehicle crashes in dementia of the Alzheimer type, Ann. Neurol. 24 (1988) 782-786.
7. L.E. Hakamies-Blomqvist, Fatal accidents of older drivers, Accid. Anal. Prey. 25 (1993) 19-27.
8. L. Harms, Variation in drivers' cognitive load. Effects of driving through village areas and rural intersections, Ergonomics 34 (1991) 151-160.
9. A. Ott, M.M. Breteler, F. van Harskamp, J.J. Clauss, T.J.M. van der Cammen, D.E. Grobbee, A. Hofman, Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam Study, Br. Med. J 310 (1995) 970-973.
10. K. Ritchie, D. Kileda, Is senile dementia "age-related" or "ageing-related" ?-evidence from meta-analysis of dementia prevalence in the oldest old, Lancet 346 (1995) 931-934.
11. L. Hunt, J.C. Morris, D. Edwards, B.S. Wilson, Driving performance in persons with mild senile dementia of the Alzheimer type, J. Am. Geriatr. Soc. 41 (1993) 747-753.
12. K. Johansson, L. Bronge, A. Persson, M. Seideman, M. Viitanen, Can a physician recognize an older driver with increased crash risk potential?, J. Am. Geriatr. Soc. 44 (1996) 1198-1204.
13. M.M. Esiri, B.T. Hyman, K. Beyreuther, C.L. Masters, Ageing and dementia, in: D.I. Graham, P.L. Lantos (Eds.), Greenfield's Neuropathology, 6th ed., Edward Arnold, London, Sydney, Auckland, 1997, pp. 153-233.
14. B.E. Tomlinson, G. Henderson, Some quantitative cerebral findings in normal and demented old people, in: R.D. Terry, S. Gershon (Eds.), Neurobiology of Aging, Raven Press, New York, NY, 1976, pp. 183-204.
15. T. Polvikoski, R. Sulkava, M. Haltia, K. Kainulainen, A. Vuorio, A. Verkkoniemi, L. Niinisto, P. Halonen, K. Kontula, Apolipoprotein E, dementia, and cortical deposition of beta-amyloid protein, N. Engl. J. Med. 333 (1995) 1242-1247.
16. C. Lundberg, K. Johansson, K. Ball et al., Dementia and driving an attempt at consensus, Alzheimers Dis. Assoc. Disord. 11 (1997) 28-37.
17. K. Johansson, N. Bogdanovic, H. Kalimo, B. Winblad, M. Viitanen, Alzheimer's disease and apolipoprotein E ε4 allele in older drivers who died in automobile accidents, Lancet 349 (1997) 1143-1144.
18. S.S. Mirra, A. Heyman, D. McKeel, S.M. Sumi, B.J. Cram, L.M. Brownlee, F.S. Vogel, J.P. Hughes, G. van Belle, L. Berg, The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease, Neurology 41 (1991) 479-486.
19. T. Yamamoto, A. Hirano, A comparative study of modified Bielschowsky, Bodian and thioflavin S stains on Alzheimer's neurofibrillary tangles, Neuropathol. Appl. Neurobiol. 12 (1986) 3-9.
20. B.C. Horten, L.J. Rubinstein, Primary cerebral neuroblastoma. A clinicopathological study of 35 cases, Brain 99 (1976) 735-756.
21. D.G. Altman (Ed.), Practical statistics for medical research, Chapman and Hall, London, 1991, pp. 268-269.
22. N. Bogdanovic, J.C. Morris, in: FF. Cruz-Sánchez, R. Ravid, M.L. Cuzner (Eds.) Neuropathological Diagnostic Criteria for Brain Banking. Biomedical and health research series, IOS Press, Amsterdam, 1995, pp. 20-29.
23. Z.S. Khachaturian, Diagnosis of Alzheimer's disease, Arch. Neurol. 42 (1985) 1097-1105.
24. M.C. Tierney, R.H. Fisher, A.J. Lewis, et al., The NINCDS-ADRDA work group criteria for the clinical diagnosis of probable Alzheimer's disease: a clinicopathologic study of 57 cases, Neurology 38 (1988) 359-364.
25. Consensus recommendations for the postmortem diagnosis of Alzheimer's disease, The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease, Neurobiol. Aging 18 (1997) (Suppl. 4) S1-S2.
26. H. Braak, E. Braak, Neuropathological staging of Alzheimer-related changes, Acta Neuropathol. 82 (1991) 239-259.
27. A.C. McKee, K.S. Kosik, N.W. Kowall, Neuritic pathology and dementia in Alzheimer's disease, Ann. Neurol. 30 (1991) 156-165.
28. B.T. Hyman, J.Q. Trojanowski, Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease, J. Neuropathol. Exp. Neurol. 56 (1997) 1095-1097.
29. S.S. Mirra, M.N. Hart, R.D. Terry, Making the diagnosis of Alzheimer's disease. A primer for practicing pathologists, Arch. Pathol. Lab. Med. 117 (1993) 132-144.
30. D.I. Graham, S.M. Gentleman, A. Lynch, G.W Roberts, Distribution of beta-amyloid protein in the brain following severe head injury, Neuropathol. Appl. Neurobiol. 21 (1995) 27-34.
31. D.W. Dickson, H.A. Crystal, L.A. Mattiace, et al., Identification of normal and pathological aging in prospectively studied nondemented elderly humans, Neurobiol. Aging 13 (1992) 179-189.
32. J.C. Morris, D.W. McKeel, M. Storandt, E.H. Rubin, J.L. Price, E.A. Grant, M.J. Ball, L. Berg, Very mild Alzheimer's disease: informant based clinical, psychometric, and pathologic distinction from normal aging, Neurology 41 (1991) 469-478.
33. J.C. Morris, M. Storandt, D.W. McKeel, E.H. Rubin, J.L. Price, E.A. Grant, L. Berg, Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymptomatic or very mild Alzheimer's disease, Neurology 41 (1991) 469-478.
34. R.A. Bloedow, G. Adler, Driving and dementia: Perspectives from an outpatient clinic, Soc. Work Health Care 17 (1992) 31-43.
35. G. Adler, S.J. Rottunda, M.W. Dysken, The driver with dementia. A review of the literature, Am. J. Geriatr. Psychiatry 4 (1996) 110-120.