Interleukin-2 inhibits HIV-1 replication in human macrophages by modulating expression of CD4 and CC-chemokine receptor-5

AIDS

Volumn 12, Issue 8, 1998, Pages

  Kutza, Joseph ^a   Hayes, Mark P ^a   Clouse, Kathleen A ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

AIDS; Cytokines; HIV; Immunotherapy; Macrophages; Monocytes

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR; COLONY STIMULATING FACTOR 1; RECOMBINANT INTERLEUKIN 2; RNA DIRECTED DNA POLYMERASE;

ARTICLE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS INHIBITION;

EID: 0032574906     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199808000-00001     Document Type: Article

References (37)

1. Lane HC, Siegel JP, Rook AH, et al.: Use of interleukin-2 in patients with acquired immunodeficiency syndrome. J Bio Resp Mod 1984, 3:512-516.
2. Volberding PV, Moody DJ, Beardslee D, Bradley EC, Wofsy CB: Therapy of acquired immune deficiency syndrome with recombinant interleukin-2. AIDS Res Hum Retrovriues 1987, 3:115-124.
3. Schwartz DH, Skowron GS, Merigan TC: Safety and effects of interleukin-2 plus zidovudine in asymptomatic individuals infected with human immunodeficiency virus. J Acquir Immune Defic Syndr 1991, 4:11-23.
4. Mazza P, Bocchia M, Tumietto F, et al.: Recombinant interleukin-2 (rlL-2) in acquired immune deficiency syndrome (AIDS): preliminary report in patients with lymphoma associated with HIV infection. Eur J Haematol 1992, 49:1-6.
5. Teppler H, Kaplan G, Smith K, et al.: Efficacy of low doses of the polyethylene glycol derivative of interleukin-2 in modulating the immune response of patients with human immunodeficiency virus type 1 infection. J Infect Dis 1993, 167:291-298.
6. Schnittman SM, Vogel S, Baseler M, Lane HC, Davey RT Jr: A phase I study of interferon-alpha 2b in combination with interleukin-2 in patients with human immunodeficiency virus infection. J Infect Dis 1994, 169:981-989.
7. Kovacs JA, Baseler M, Dewar RJ, et al.: Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. A preliminary study. N Engl J Med 1995, 332:567-575.
8. Ramachandran R, Katzenstein DA, Winters MA, Kundu SK, Merigan TC: Polyethylene glycol-modified interleukin-2 and thymosin alpha 1 in human immunodeficiency virus type 1 infection. J Infect Dis 1996, 173:1005-1008.
9. Jacobson EL, Pilaro F, Smith KA: Rational interleukin 2 therapy for HIV positive individuals: daily low doses enhance immune function without toxicity. Proc Natl Acad Sci USA 1996, 93:10405-10410.
10. Piscitelli SC, Wells MJ, Metcalf JA, Baseler M, Stevens R, Davey Jr RT: Pharmokinetics and pharmacodynamics of subcutaneous interleukin-2 in HIV-infected patients. Pharmacotherapy 1996, 16:754-759.
11. Brach MA, Arnold C, Kiehntopf M, Gruss HJ, Herrmann F: Transcriptional activation of the macrophage colonystimulating factor gene by IL-2 is associated with secretion of bioactive macrophage colony-stimulating factor protein by monocytes and involves activation of the transcription factor NF-kappa B. J Immunol 1993, 150:5535-5543.
12. Espinoza-Delgado I, Longo DL, Gusella GL, Varesio L: IL-2 enhances c-fms expression in human monocytes. J Immunol 1990, 145:1137-1143.
13. Kalter DC, Nakamura M, Turpin JA, et al.: Enhanced HIV replication in macrophage colony-stimulating factor-treated monocytes. J Immunol 1991, 146:298-306.
14. Bergamini A, Perno CF, Dini L, et al.: Macrophage colonystimulating factor enhances the susceptibility of macrophages to infection by human immunodeficiency virus and reduced the activity of compounds that inhibit virus binding. Blood 1994, 84:3405-3412.
15. Gruber MF, Weih KA, Boone EJ, Smith PD, Clouse KA: Endogenous macrophage CSF production is associated with viral replication in HIV-1-infected human monocyte-derived macrophages. J Immunol 1995, 154:5528-5535.
16. Gerrard TL, Jurgensen CH, Fauci AS: Differential effect of monoclonal anti-DR antibody on monocytes in antigen-and mitogen-stimulated responses: mechanism of inhibition and relationship to interleukin-1 secretion. Cell Immunol 1983, 82:394-402.
17. Gendelman HE, Orenstein JM, Baca LM, et al.: The macrophage in the persistence and pathogenesis of HIV infection. AIDS 1989, 3:475-495.
18. Gendelman HE, Orenstein JM, Martin MA, et al.: Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1 -treated monocytes. J Exp Med 1988, 167:1428-1441.
19. Hoffman AD: Characterization of the AIDS-associated retrovirus reverse transcriptase and optimal conditions for its detection in virions. Virology 1985, 147:326-335.
20. Nakoinz IM, Lee MT, Weaver JF, Ralph P: Differentiation of the IL-3 dependent NFS-60 cell line and adaptation to growth in macrophage colony stimulating factor. J Immunol 1990, 145:860-864.
21. Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65:55-63.
22. Wu L, Paxton WA, Kassam N, et al.: CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. J Exp Med 1997, 185:1681-1691.
23. Canque B, Rosenwajg M, Gey A, Tartour E, Fridman WH, Gluckman JC : Macrophage inflammatory protein-1 alpha is induced by human immunodeficiency virus infection of monocyte-derived macrophages. Blood 1996, 87:2011-2019.
24. Schmidtmayerova H, Nottet HS, Nuovo G, et al.: Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes. Proc Natl Acad Sci USA 1996, 93:700-704.
25. Collier AC, Coombs RW, Schoenfeld DA, Bassett R, Barurh A, Corey L: Combination therapy with zidovudine, didanosine and saquinavir. Antiviral Res 1996, 29:99.
26. Vella S: Clinical experience with saquinavir. AIDS 1995, 9 (suppl 2):S21-S25.
27. Espinoza-Delgado I, Ortaldo ]R, Winkler-Pickett R, Sugamura K, Varesio L, Longo DL: Expression and role of p75 interleukin 2 receptor on human monocytes. J Exp Med 1990, 171: 1821-1826.
28. Bosro MC, Espinoza-Delgado I, Schwabe M, Leonard WJ, Longo DL, Varesio L: The gamma chain of the interleukin-2 receptor is expressed in human monocytes and modulated by interleukin-2, interferon-gamma, and transforming growth factor-beta 1. Blood 1994, 83:3462-3467.
29. Wahl SM, McCartney-Francis N, Hunt DA, Smith PD, Wahl LM, Katona IM: Monocyte interleukin-2 receptor gene expression and interleukin-2 augmentation of microbicidal activity. J Immunol 1987, 139:1342-1347.
30. Malkovský M, Loveland B, North M, et al.: Recombinant interleukin-2 directly augments the cytotoxicity of human monocytes. Nature 1987, 325:262-265.
31. Strieter RM, Remick DG, Lynch III JP, Spengler RN, Kunkel SL: Interleukin-2 induced tumor necrosis factor alpha (TNF-alpha) gene expression in human alveolar macrophages and blood monocytes. Am Rev Respir Dis 1989, 139:335-142.
32. Kovacs EJ, Brock E, Varesio L, Young HA: IL-2 induction of IL-1 beta mRNA expression in monocytes. Regulation by agents that block second messenger pathways. J Immunol 1989, 143:3532-3537.
33. Musso T, Espinoza-Delgado I, Pulkki K, Gusella GL, Longo DL, Varesio L: IL-2 induces IL-6 production in human monocytes. J Immunol 1992, 148:795-800.
34. Remick DG, Larrick JW, Nguyen DT, Kunkel SL : Stimulation of prostaglandin E2 and thromboxane B2 production by human monocytes in response to interleukin-2. Biochem Biophys Res Commun 1987, 147:86-93.
35. Potts BJ, Maury W, Martin MA: Replication of HIV-1 in primary monocyte cultures. Virology 1990, 175:465-476.
36. Schuitmaker H, Kootstra NA, Koppelman MH, et al.: Proliferation-dependent HIV-1 infection of monocytes occurs during differentiation into macropahges. J Clin Invest 1992, 89:1154-1160.
37. Naif HN, Li S, Alali M, et al.: CCR5 expression correlates with susceptibility of maturing monocytes to human immunodeficiency virus type 1 infection. J Virol 1998, 72:850-836.