Expression of a fusion gene consisting of the mouse growth hormone-releasing hormone gene promoter linked to the SV40 T-antigen gene in transgenic mice

Molecular and Cellular Endocrinology

Volumn 137, Issue 2, 1998, Pages 161-168

  Nogues, N ^a   Magnan, E ^a   De Grandis, P ^a   Butz, M ^a   Kineman, R D ^a   Kopchick, J J ^b   Frohman, L A ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b OHIO UNIVERSITY   (United States)

Author keywords

Eye; GHRH; Hypothalamus; SV40 T antigen; Testis; Transgenic

Indexed keywords

GROWTH HORMONE RELEASING FACTOR; T LYMPHOCYTE ANTIGEN; VIRUS ANTIGEN;

ADRENAL GLAND; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; CATARACT; CEREBELLUM; CONTROLLED STUDY; DNA FLANKING REGION; EXON; FEMALE; FERTILITY; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE FUSION; GENE SEQUENCE; HYPOPHYSIS; HYPOTHALAMUS; INTRON; LUNG; MALE; MOUSE; NONHUMAN; NORTHERN BLOTTING; OOCYTE; PLACENTA; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIMIAN VIRUS 40; SOUTHERN BLOTTING; SPINAL CORD; SPLEEN; TESTIS; TISSUE DISTRIBUTION; TRANSCRIPTION INITIATION; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; ARTIFICIAL GENE FUSION; BASE SEQUENCE; DNA PRIMERS; EYE; GENE EXPRESSION; GROWTH HORMONE-RELEASING HORMONE; HYPOTHALAMUS; LINKAGE (GENETICS); MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); TESTIS;

EID: 0032574304     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(97)00242-6     Document Type: Article

References (27)

1. Aleppo G., Moskal S.E.I., DeGrandis P.A., Kineman R.D., Frohman L.A. Homologous down-regulation of growth hormone-releasing hormone receptor mRNA levels. Endocrinology. 138:1997;1058-1065.
2. Asa S.L., Scheithauer B.W., Bilbao J.M., Horvath E., Ryan N., Kovacs K., Randall R.V., Laws E.R. Jr, Singer W., Linfoot J.A., Thorner M.O., Vale W. A case for hypothalamic acromegaly: a clinicopathological study of six patients with hypothalamic gangliocytomas producing growth hormone releasing factor. J. Clin. Endocrinol. Metab. 58:1984;796-803.
3. Baetscher M., Schmidt E., Shimizu A., Leder P., Fishman M.C. SV40 T antigen transforms calcitonin cells of the thyroid but not CGRP-containing neurons in transgenic mice. Oncogene. 6:1991;1133-1138.
4. Boronat A., Nogues N., Gonzalez-Crespo S., Dominguez V., Vidal F., Perez-Riba M. Extrahypothalamic expression of growth hormone-releasing hormone. Isidori A., New M.l., Pavia Sesma C.P. Molecular Basis of Endocrine Diseases. 1994;15-25 Aries-Serono Symp. Public. Geneva.
5. Botteri F.M., van der Putten H., Wong D.F., Sauvage C.A., Evans R.M. Unexpected thymic hyperplasia in transgenic mice harboring a neuronal promoter fused with simian virus 40 large T antigen. Mol. Cell. Biol. 7:1987;3178-3184.
6. Bryce D.M., Liu Q., Khoo W., Tsuli L.C., Breitman M.L. Progressive and regressive fate of lens tumors correlates with subtle differences in transgene expression in gamma-F-crystallin-SV40 T antigen transgenic mice. Oncogene. 8:1993;1611-1620.
7. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
8. Efrat S., Hanahan D. Evidence for threshold effects in transformation of pancreatic B Cells by SV40 T antigen in transgenic mice. Curr. Top. Microbiol. Immunol. 144:1989;89-95.
9. Efrat S., Linde S., Kofod H., Spector D., Delannoy M., Grant S., Hanahan D., Baekkeskov S. Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene. Proc. Natl. Acad. Sci. USA. 85:1988;9037-9041.
10. Gonzalez-Crespo S., Boronat A. Expression of the rat growth hormonereleasing hormone gene in placenta is directed by an alternative promoter. Proc. Natl. Acad. Sci. USA. 88:1991;8749-8753.
11. Lew D., Brady H., Klausing K., Yaginuma K., Theill L.E., Stauber C., Karin M., Mellon P.L. GHF-1-promoter-targeted immortalization of a somatotropic progenitor cell results in dwarfism in transgenic mice. Genes Dev. 7:1993;683-693.
12. Matsubara S., Sato M., Mizobuchi M., Niimi M., Takahara J. Differential gene expression of growth hormone (GH)-releasing hormone (GRH) and GRH receptor in various rat tissues. Endocrinology. 136:1995;4147-4150.
13. Mayo K.E., Godfrey P.A., Suhr S.T., Kulik D.J., Rahal J.O. Growth hormone releasing hormone synthesis and signalling. Rec. Prog. Horm. Res. 50:1995;35-73.
14. Mayo K.E., Miller T.L., DeAlmeida V., Zheng J., Godfrey P.A. The growthhormone-releasing hormone receptor: signal transduction, gene expression and physiological function in growth regulation. Ann. New York Acad. Sci. 805:1996;184-203.
15. Mellon P.L., Windle J.J., Goldsmith P.C., Padula C.A., Roberts J.L., Weiner R.I. Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron. 5:1990;1-10.
16. Miki N., Ono M., Asakawa-Yasumoto K., Aoki T., Murata Y., Ishituka Y., Demura H., Sasaki F. Characterization and localization of mouse hypothalamic growth hormone-releasing factor and effect of gold thioglucose-induced hypothalamic lesions. J. Neuroendocrinol. 6:1996;71-78.
17. Mizobuchi M., Frohman M.A., Downs T.R., Frohman L.A. Tissue-specific transcription initiation and effects of growth hormone (GH) deficiency on the regulation of mouse and rat GH-releasing hormone (GRH) gene in hypothalamus and placenta. Mol. Endocrinol. 5:1991;476-484.
18. Nakamura T., Mahon K., Miskin R., Dey A., Kuwabara T., Westphal H. Differentiation and oncogenesis: phenotypically distinct lens tumors in transgenic mice. New Biol. 1:1989;193-204.
19. Nogues, N., DelRio, J.A., Perez-Riba, M., Soriano, E., Flavell, R.A., Boronat, A., 1997. Placental-specific expression of the rat growth hormone-releasing hormone gene promoter in transgenic mice. Endocrinology (in press).
20. Paul D., Hohne M., Pinkert C., Piasecki A., Ummelmann E., Brinster R.L. Immortalized differentiated hepatocyte lines derived from transgenic mice harboring SV40 T-antigen genes. Exp. Cell. Res. 175:1988;354-362.
21. Pecori Giraldi F., Mizobuchi M., Horowitz F., Downs T.R., Kier A., Kopchick J.J., Frohman L.A. Development of neuroepithelial tumors of the adrenal medulla in transgenic mice expressing a mouse hypothalamic growth hormone-releasing hormone (GRH) promoter SV40 T antigen fusion gene. Endocrinology. 134:1994;1219-1224.
22. Reynolds R.K., Hoekzema G.S., Vogel J., Hinrichs S.H., Jay G. Multiple endocrine neoplasia induced by the promiscuous expression of a viral oncogene. Proc. Natl. Acad. Sci. USA. 85:1988;3135-3139.
23. Sawchenko P.E., Swanson L.W., Rivier J., Vale W.W. The distribution of growth-hormone-releasing factor (GRF) immunoreactivity in the central nervous system of the rat: an immunohistochemical study using antisera directed against rat hypothalamic GRF. J. Comp. Neurol. 237:1985;100-115.
24. Shibasaki T., Kiyosawa Y., Masuda A., Nakahara M., Imaki T., Wakabayashi I., Demura H., Shizume K., Ling N. Distribution of growth hormone-releasing hormone-like immunoreactivity in human tissue extracts. J. Clin. Endocrinol. Metab. 59:1984;263-268.
25. Srivastava C.H., Monts B.S., Rothrock J.K., Peredo M.J., Pescovitz O.H. Presence of a spermatogenic-specific promoter in the rat growth hormone releasing hormone gene. Endocrinology. 136:1995;1502-1508.
26. Suhr S.T., Rahal J.O., Mayo K.E. Mouse growth hormone-releasing hormone: Precursor structure and expression in brain and placenta. Mol. Endocrinol. 3:1989;1693-1700.
27. Wagner T.E., Hoppe P.C., Jollick J.D., Scholl D.R., Hodinka R.L., Gault J.B. Microinjection of a rabbit b-globin gene into zygotes and its subsequent expression in adult mice and their offspring. Proc. Natl. Acad. Sci. USA. 78:1981;6376-6380.