A single minute lesion around the ventral respiratory group in medulla produces fatal apnea in cats

Journal of the Autonomic Nervous System

Volumn 73, Issue 1, 1998, Pages 7-18

  Hsieh, J H ^a   Chang, Y C ^a   Su, C K ^a   Hwang, J C ^a   Yen, C T ^a   Chai, C Y ^a  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

Apnea; Midsagittal division in medulla; Phrenic nerve activity; Ventral respiratory group

Indexed keywords

CHLORALOSE; KAINIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APNEA; ARTICLE; ARTIFICIAL VENTILATION; BRAIN STEM; BREATHING PATTERN; CONTROLLED STUDY; ELECTROSTIMULATION; FEMALE; MALE; MEDULLA OBLONGATA; MICROINJECTION; MICROPIPETTE; NONHUMAN; PHRENIC NERVE; PRIORITY JOURNAL; RESPIRATION CENTER; RESPIRATION CONTROL;

ANIMALS; APNEA; AUTONOMIC NERVOUS SYSTEM; CATS; DENERVATION; ELECTRIC STIMULATION; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GLUCOSE; KAINIC ACID; KYNURENIC ACID; MALE; MEDULLA OBLONGATA; MICROELECTRODES; MICROINJECTIONS; NEURAL CONDUCTION; PHRENIC NERVE; PHYSICAL STIMULATION; RESPIRATION;

EID: 0032572732     PISSN: 01651838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1838(98)00117-9     Document Type: Article

References (34)

1. Adams M., Chonan T., Cherniack N.S., von Euler C. Effects on respiratory pattern of focal cooling in the medulla of the dog. J. Appl. Physiol. 65:1988;2004-2010.
2. Amendt K., Czachurski J., Dembowsky K., Seller H. Bulbospinal projections to the intermediolateral cell column; a neuroanatomical study. J. Auton. Nerv. Syst. 1:1979;103-117.
3. Bianchi A.L., Denavit-Saubie M., Champagnat J. Central control of breathing in mammals: neuronal circuitry, membrane properties, and neurotransmitters. Physiol. Rev. 75:1995;1-45.
4. Bingmann D., Baker R.E., Ballantyne D. Rhythm generation in brainstem cultures grown in a serum-free medium. Neurosci. Lett. 132:1991;167-170.
5. Bongianni F., Corda M., Fontana G.A., Pantaleo T. Excitatory and depressant respiratory responses to chemical stimulation of the rostral ventrolateral medulla in the cat. Acta Physiol. Scand. 148:1993;315-325.
6. Budzinska K., von Euler C., Kao F.F. Effects of graded focal cold block in rostral areas of the medulla. Acta. Physiol. Scand. 124:1985;329-340.
7. Chai C.Y., Lin R.H., Lin A.M.Y., Pan C.M., Lee E.H.Y., Kuo J.S. Pressor responses from electrical or glutamate stimulations of the dorsal or ventrolateral medulla. Am. J. Physiol. 255:1988;R709-R717.
8. Chai C.Y., Mu J.Y., Brobeck J.R. Cardiovascular and respiratory responses from local heating of medulla oblongata. Am. J. Physiol. 209:1965;301-306.
9. Chai C.Y., Wang S.C. Localization of central cardiovascular control mechanism in lower brain stem of the cat. Am. J. Physiol. 202:1962;25-30.
10. Chitravanshi V.C., Sapru H.N. NMDA as well as non-NMDA receptors in phrenic nucleus mediate respiratory effects of carotid chemoreflex. Am. J. Physiol. 272:1997;R302-R310.
11. Connelly C.A., Dobbins E.G., Feldman J.L. Pre-Bötzinger complex in cats: respiratory neuronal discharge patterns. Brain Res. 590:1992;337-340.
12. Feldman, J.L., Smith, J.C., 1989. Cellular mechanism underlying modulation of breathing pattern in mammals. In: Davis, M., Jacobs, B.L., Schpenfeld, R.I. (Eds.), Modulation of Defined Vertebral Neural Circuit. Ann. N.Y. Acad. Sci. 563, 114-130.
13. án et al., 1997.
14. Gaytán S.P., Pedro F.C., Núñez-Abades A., Morillo A.M., Pásaro R. Pontomedullary efferent projections of the ventral respiratory neuronal subsets of the rat. Brain Res. Bull. 42:1997;323-334.
15. Gromysz H., Karczewski W.A. Phrenic motoneurone activity in split-brainstem cats and monkeys. Respir. Physiol. 50:1982;51-61.
16. Guyenet P.G., Koshiya N. Working model of the sympathetic chemoreflex in rats. Clin. Exp. Hypertens. 17:1995;167-179.
17. Howard B.R., Tabatabai M. Localization of the medullary respiratory neurons in rats by microelectrode recording. J. Appl. Physiol. 39:1975;812-817.
18. Hwang, J.J., 1994. Correlation between the pressor areas of the periaqueductal grey and the cardiovascular reactive areas of medulla in cats. Master of Science thesis of the National Yang-Ming Medical College (Supervisor C.Y. Chai).
19. Hwang J.C., Su C.K., Yen C.T., Chai C.Y. Presence of neuronal cell bodies in the sympathetic pressor areas of dorsal and ventrolateral medulla inhibiting phrenic nerve discharges in cats. Clin. Auton. Res. 2:1992;189-196.
20. Kubin L., Trzebski A., Lipski J. Split medulla preparation in the cat: arterial chemoreceptor reflex and respiratory modulation of the renal sympathetic nerve activity. J. Auton. Nerv. Syst. 12:1985;211-225.
21. Magoun, H.W., 1963. The Waking Brain, 2nd edn. Charles C. Thomas, Spring Field.
22. Monteau R., Hilare G. Spinal respiratory motoneurons. Prog. Neurobiol. 37:1991;83-144.
23. Onimaru H. A studies of the respiratory center using isolated brainstem-spinal cord preparation. Neurosci. Res. 21:1995;183-190.
24. Onimaru H., Arata A., Homma I. Primary respiratory rhythm generator in the medulla of brainstem spinal cord preparations from newborn rats. Brain Res. 445:1988;314-324.
25. Onimaru H., Arata A., Homma I. Firing properties of respiratory rhythm generating neurons in the absence of synaptic transmission in rat medulla in vitro. Exp. Brain Res. 76:1989;530-536.
26. Paton J.F.R., Ramirez J.-M., Richter W. Mechanism of respiratory rhythm generation change profoundly during early life in mice and rats. Neurosci. Lett. 170:1994;167-170.
27. Richter D.W., Ballangi K., Schwarzacher S. Mechanism of respiratory rhythm generation. Curr. Opin. Neurobiol. 2:1992;788-793.
28. 2 and low pH. J. Neurosci. Res. 33:1992;590-597.
29. Smith, J.C., Feldman, J.L., 1987. Central respiratory pattern generation studied in an in vitro mammalian brainstem spinal cord preparation. In: Sieck, G.C., Gandevia, S.G., Cameron, W.E. (Eds.), Respiratory Muscles and Their Neuromotor Control. Liss, New York, pp. 27-36.
30. Smith J.C., Ellenberger H.H., Ballanyi K., Richter D.W., Feldman J.L. Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science. 254:1991;726-729.
31. Speck D.F. Bötzinger complex region role in phrenic-to-phrenic inhibitory reflex of cat. J. Appl. Physiol. 67:1989;1364-1370.
32. Su C.K., Chen S.Y., Yang J.M., Lin R.H., Horng H.T., Hwang J.C., Chai C.Y. Correlation of cardiovascular and respiratory responses to glutamate excitation of pressor areas of the medulla in cats. Chin. J. Physiol. 35:1992;279-289.
33. Wang S.D., Yen K.D., Pan C.M., Liu J.C., Kuo J.S., Chai C.Y. Descending pressor pathways from the dorsomedial and ventrolateral medulla of cats. Chin. J. Physiol. 39:1996;31-42.
34. Wang, S.C., 1980. Physiology and Pharmacology of the Brain Stem. Futura Publishing, New York.