Cholesterol homeostasis: A role for oxysterols

Current Biology

Volumn 8, Issue 17, 1998, Pages

  Accad, Michel ^a   Farese Jr , Robert V ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0032572729     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0960-9822(98)70386-0     Document Type: Article

References (11)

1. Brown MS, Goldstein JL: Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol. J Biol Chem 1974, 249:7306-7314.
2. Kandutsch AA, Chen HW: Inhibition of sterol synthesis in cultured mouse cells by cholesterol derivatives oxygenated in the side chain. J Biol Chem 1974, 249:6057-6061.
3. Taylor FR, Kandutsch AA: Oxysterol binding protein. Chem Phys Lipids 1985, 38:187-194.
4. Dawson PA, Ridgway ND, Slaughter CA, Brown MS, Goldstein JL: cDNA cloning and expression of oxysterol-binding protein, an oligomer with a potential leucine zipper. J Biol Chem 1989, 264:16798-16803.
5. Brown MS, Goldstein JL: The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997, 89:331-340.
6. Chang TY, Hasan MT, Chin J, Chang CC, Spillane DM, Chen J: Chinese hamster ovary cell mutants affecting cholesterol metabolism. Curr Opin Lipidol 1997, 8:65-71.
7. Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ: LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev 1995, 9:1033-1045.
8. Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ: An oxysterol signalling pathway mediated by the nuclear receptor LXRα. Nature 1996, 383:728-731.
9. Lehmann JM, Kliewer SA, Moore LB, Smith-Oliver TA, Oliver BB, Su J-L, Sundseth SS, Winegar DA, Blanchard DE, Spencer TA, Willson TM: Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem 1997, 272:3137-3140.
10. Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro J-MA, Hammer RE, Mangelsdorf DJ: Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα. Cell 1998, 93:693-704.
11. Forman BM, Ruan B, Chen J, Schroepfer GJ Jr, Evans RM: The orphan nuclear receptor LXRa is positively and negatively regulated by distinct products of mevalonate metabolism. Proc Natl Acad Sci USA 1997, 94:10588-10593.