Effects of 6-N-propyl-2-thiouracil on growth, hormonal profiles, carcass and reproductive traits of boars

Animal Reproduction Science

Volumn 50, Issue 1-2, 1998, Pages 81-94

  Tarn, C Y ^a   Rosenkrans Jr , C F ^a   Apple, J K ^a   Kirby, J D ^a  

^a UNIVERSITY OF ARKANSAS   (United States)

Author keywords

Carcass quality; Hypothyroidism; Pig male reproduction

Indexed keywords

ESTRADIOL; FOLLITROPIN; HORMONE; PROPYLTHIOURACIL; TESTOSTERONE; THYROXINE;

AGING; ANIMAL; ARTICLE; BLOOD; BODY COMPOSITION; BODY TEMPERATURE; BODY WEIGHT; CLINICAL TRIAL; DRUG EFFECT; EATING; GROWTH; MALE; RANDOMIZED CONTROLLED TRIAL; REPRODUCTION; SPERMATOZOON COUNT; SWINE;

AGING; ANIMALS; BODY COMPOSITION; BODY TEMPERATURE; BODY WEIGHT; EATING; ESTRADIOL; FOLLICLE STIMULATING HORMONE; GROWTH; HORMONES; MALE; PROPYLTHIOURACIL; REPRODUCTION; SPERM COUNT; SWINE; TESTOSTERONE; THYROXINE;

ANIMALIA; DOA; RODENTIA; SUS SCROFA;

EID: 0032570505     PISSN: 03784320     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4320(97)00091-2     Document Type: Article

References (46)

1. Allrich R.D., Christenson R.K., Ford J.J., Zimmerman D.R. Pubertal development of the boar: testosterone, estradiol-17b, cortisol and LH concentrations before and after castration at various ages. J. Anim. Sci. 55:1982;1139-1146.
2. Allrich R.D., Christenson R.K., Ford J.J., Zimmerman D.R. Pubertal development of the boar: age-related changes in testicular morphology and in vitro production of testosterone and estradiol-17b pigs. Biol. Reprod. 28:1982;902-909.
3. Arieli A., Chinet A. Thyroid status and noradrenaline-induced regulatory thermogenesis in heat acclimated rats. Horm. Metab. Res. 18:1986;103-106.
4. Barker S.B., Klitgaard H.W. Metabolism of tissues excised from thyroxine-injected rats. Am. J. Physiol. 170:1952;81.
5. Beeson W.M., Ansdrews F.N., Perry T.W., Witz H.L. Jr. The effect of thyroprotein and thiouracil on the growth and fattening of swine. J. Anim. Sci. 8:1949;508-517.
6. Brown J.L., Chakraborty P.K. Comparison of compensatory pituitary and testicular responses to hemicastration between prepubertal and mature rats. J. Androl. 12:1991;119-125.
7. Bunick D., Kirby J.D., Hess R.A., Cooke P.S. Developmental expression of testis messenger ribonucleic acids in the rat following propylthiouracil-induced neonatal hypothyroidism. Biol. Reprod. 51:1994;706-713.
8. Chandrasekhar Y., D'Occhio M.J., Setchell B.P. Reproductive hormone secretion and spermatogenic function in thyroidectomized rams receiving graded doses of exogenous thyroxine. J. Endocrinol. 111:1986;245-253.
9. Cooke P.S. Thyroid hormones and testis development: a model system for increasing testis growth and sperm production. Ann. NY Acad. Sci. 637:1991;122-132.
10. Cooke P.S., Meisami E. Early hypothyroidism in rat increases adult testis and reproductive organ size but dose not change testosterone levels. Endocrinology. 129:1991;237.
11. Cooke P.S., Hess R.A., Porcelli J., Meisami E. Increased sperm production in adult rats after transient neonatal hypothyroidism. Endocrinology. 129:1991;244-248.
12. Cooke P.S., Porcelli J., Hess R.A. Induction of increased testis growth and sperm production in adult rats by neonatal administration of the goitrogen propylthiouracil (PD): the critical period. Biol. Reprod. 46:1992;146-154.
13. Cooke P.S., Kirby J.D., Porcelli J. Increased testis growth and sperm production in adult rats following transient neonatal goitrogen treatment: optimization of the propylthiouracil dose and effects of methimazole. J. Reprod. Fertil. 97:1993;493-499.
14. Cooke P.S., Hess R.A., Kirby J.D. A model system for increasing testis size and sperm production: potential application to animal science. J. Anim. Sci. 72:1994;43-54. Suppl. 3.
15. Cooke P.S., Zhao Y.D., Bunick D. Triiodothyronine inhibits proliferation and stimulates differentiation of cultured neonatal Sertoli cells: possible mechanism for increased adult testis weight and sperm production induced by neonatal goitrogen treatment. Biol. Reprod. 51:1994;1000-1005.
16. De Franca L.R., Hess R.A., Cooke P.S., Russell R.D. Neonatal hypothyroidism causes delayed Sertoli cell maturation in rats treated with propylthiouracil: evidence that the Sertoli cell controls testis growth. Anat. Rec. 242:1996;57-69.
17. Ford J.J., Wise T.H., Lunstra D.D. Negative relationship between blood concentrations of follicle-stimulating hormone (FSH) and testicular size in mature boars. J. Anim. Sci. 75:1997;790-795.
18. Hess R.A., Cooke P.S., Bunick D., Kirby J.D. Adult testicular enlargement induced by neonatal hypothyroidism is accompanied by increased Sertoli and germ cell numbers. Endocrinology. 132:1993;2607-2613.
19. Jannini E.A., Olivieri M., Francavilla S., Gulino A., Ziparo E., D'Armiento M. Ontogenesis of the nuclear 3,5,3′-triiodothyronine receptor in the rat testis. Endocrinology. 126:1990;2521-2526.
20. Jannini E.A., Ulisse S., D'Armiento M. Thyroid hormone and male gonadal function. Endocr. Rev. 16:1995;443-459.
21. Joyce K.L., Porcelli J., Cooke P.S. Neonatal goitrogen treatment increases adult testis size and sperm production in the mouse. J. Androl. 14:1993;448.
22. Kirby J.D., Jetton A.E., Cooke P.S., Hess R.A., Bunick D., Ackland J.F., Turek F.W., Schwartz N.B. Developmental hormonal profiles accompanying the neonatal hypothyroidism-induced increase in adult testicular size and sperm production in the rat. Endocrinology. 131:1992;559-565.
23. Kirby, J.D., Cooke, P.S., Arambepola, N., Bunick, D., Hess, R.A., Turek, F.W., 1993. Neonatal hypothyroidism increases adult testis size and sperm production in the hamster (Mesocricetus auratus). Program of the XIIth North American Testis Workshop, Tampa, FL, p. 51 (Abstr.).
24. Kirby J.D., Mankar M.V., Hardesty D., Kreider D.L. Effects of transient prepubertal 6-N-propyl-2-thiouracil treatment on testis development and function in the domestic fowl. Biol. Reprod. 55:1996;910-916.
25. Knudson B.K., Hogberg M.G., Merkel R.A., Allen R.E., Magee W.T. Developmental comparisons of boars and barrows: I. Growth rate, carcass and muscle characteristics. J. Anim. Sci. 61:1985;789-795.
26. Kosco M.S., Loseth K.J., Crabo B.G. Development of the testicular interstitium after neonatal hemicastration in the boar. J. Reprod. Fertil. 87:1989;13-21.
27. Luna, L.G. (Ed.), 1968. Manual of histologic staining methods of the Armed Forces Institute of Pathology, USA.
28. Martin T.L., Williams G.L., Lunstra D.D., Ireland J.J. Immunoneutralization of inhibin modifies hormone secretion and sperm production in bulls. Biol. Reprod. 45:1991;73-77.
29. McIntosh L.M., Anderson J.E. Hypothyroidism prolongs and increases mdx muscle precursor proliferation and delays myotube formation in normal and dystrophic limb muscle. Biochem. Cell Biol. 73:1995;181-190.
30. McMillen W.N., Reinete E.P., Bratzler L.J., Francis M.J. The effect of thiouracil of efficiency of gains and carcass quality in swine. J. Anim. Sci. 5:1947;305-309.
31. Meisami E., Sendera T.J., Clay L.B. Paradoxical hypertrophy and plasticity of the testis in rats recovering from early thyroid deficiency: a growth study including effects of age and duration of hypothyroidism. J. Endocrinol. 135:1992;495-505.
32. Meisami E., Najafi A., Timiras P.S. Enhancement of seminiferous tubular growth and spermatogenesis in testes of rats recovering from early hypothyroidism: a quantitative study. Cell Tissue Res. 275:1994;503-511.
33. Palmero S., De Marco P., Trucchi P., Prati M., Fugassa E. Nuclear tri-iodothyronine receptors in the testis of the growing rat are regulated by the thyroid status. Boll. Soc. Ital. Biol. Sper. 67:1991;501-508.
34. Palmero S., Benahmed K., Morera A.M., Trucchi P., Fugassa E. Identification of nuclear tri-iodothyronine receptors in Sertoli cells from immature piglet testes. J. Endocrinol. 9:1992;55-59.
35. Palmero S., Prati M., De Marco P., Trucchi P., Fugassa E. Thyroidal regulation of nuclear tri-iodothyronine receptors in the developing rat testis. J. Endocrinol. 136:1993;277-282.
36. Putra D.K., Blackshaw A.W. Quantitative studies of compensatory testicular hypertrophy following unilateral castration in the boar. Aust. J. Biol. Sci. 38:1985;429-434.
37. Reddi N.M., Rajan A. Reproductive behaviour and semen characteristics in experimental hypothyroidism in goats. Theriogenology. 25:1986;263-274.
38. SAS, 1991. SAS/STAT® User's Guide. SAS Inst., Cary, NC.
39. Schanbacher B.D., Pelletier J., Hochereau-de-Reviers M.T. Follicle-stimulating hormone, luteinizing hormone and testicular Leydig cell responses to estradiol-immunization in Ile-de-France rams. J. Androl. 8:1987;97-102.
40. Schinckel A.P., Johnson R.K., Kittok R.J. Testicular development and endocrine characteristics of boars selected for either high or low testis size. J. Anim. Sci. 58:1984;675-685.
41. Schinckel A.P., Johnson R.K., Kittok R.J. Relationships among measures of testicular development and endocrine function in boars. J. Anim. Sci. 58:1984;1255-1261.
42. Suswillo R.F.L., Watson P.F. A new light microscopy classification of spermatogenesis in the bull and the boar applicable to tissues processed for electron microscopy. Anat. Histol. Embryol. 19:1990;326-339.
43. Trout W.E., Killen J.H., Christenson R.K., Schanbacher B.D., Ford J.J. Effects of weaning on concentrations of inhibin in follicular fluid and plasma of sows. J. Reprod. Fertil. 94:1992;107-114.
44. Van Haaster L.H., De Jong F.H., Docter R., De Rooij D.G. The effect of hypothyroidism on Sertoli cell proliferation and differentiation and hormone levels during testicular development in the rat. Endocrinology. 131:1992;1574-1576.
45. Weiss S.R., Burns J.M. The effect of acute treatment with two goitrogens on plasma thyroid hormones, testosterone and testicular morphology in adult male rats. Comp. Biochem. Physiol. A Physiol. 90:1988;449-452.
46. Willman J.P., Asdell S.A., Loosli J.K. The value of thiouracil in rations for growing and fattening pigs. J. Anim. Sci. 8:1949;191-198.