Elastic bending and active tilting of myosin heads during muscle contraction

Nature

Volumn 396, Issue 6709, 1998, Pages 383-387

  Dobbie, Ian ^a   Linari, Marco ^b   Piazzesi, Gabriella ^b   Reconditi, Massimo ^b   Koubassova, Natalia ^c   Ferenczi, Michael A ^d   Lombardi, Vincenzo ^b   Irving, Malcolm ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF FLORENCE   (Italy)

^c MOSCOW STATE UNIVERSITY   (Russian Federation)

^d NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; MYOSIN LIGHT CHAIN;

ACTIN MYOSIN INTERACTION; ANIMAL TISSUE; ARTICLE; CONFORMATIONAL TRANSITION; MUSCLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN STRUCTURE; SARCOMERE; X RAY DIFFRACTION;

ACTINS; ADENOSINE TRIPHOSPHATE; ANIMALS; ELASTICITY; MOLECULAR MOTOR PROTEINS; MUSCLE CONTRACTION; MUSCLE FIBERS; MYOSINS; PROTEIN CONFORMATION; RANA TEMPORARIA; X-RAY DIFFRACTION;

ANIMALIA;

EID: 0032569808     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/24647     Document Type: Article

References (30)

1. Huxley, H. E. The mechanism of muscular contraction. Science 164, 1356-1366 (1969).
2. Huxley, A. F. Muscular contraction. J. Physiol. (Lond.) 243, 1-43 (1974).
3. Rayment, I. et al. Structure of the actin-myosin complex and its implications for muscle contraction. Science 261, 58-65 (1993).
4. Rayment, I. et al. Three-dimensional structure of myosin subfragment-1: a molecular motor. Science 261, 50-58 (1993).
5. Irving, M. et al. Tilting of the light chain region of myosin during step length changes and active force generation in skeletal muscle. Nature 375, 688-691 (1995).
6. Cooke, R. Actomyosin interaction in striated muscle. Physiol. Rev. 77, 671-697 (1997).
7. Cecchi, G., Griffiths, P. J. & Taylor, S. Muscular contraction: kinetics of cross-bridge attachment studied by high-frequency stiffness measurements. Science 217, 70-72 (1982).
8. Huxley, A. F. & Simmons, R. M. Proposed mechanism of force generation in striated muscle. Nature 233, 533-538 (1971).
9. Huxley, A. F. Muscle structure and theories of contraction. Prog. Biophys. Biophys. Chem. 7, 255-318 (1957).
10. Lombardi, V., Piazzesi, G. & Linari, M. Rapid regeneration of the actin-myosin power stroke in contracting muscle. Nature 355, 638-641 (1992).
11. Huxley, H. E., Faruqi, A. R., Kress, M., Bordas, J. & Koch, M. H. J. Time resolved X-ray diffraction studies of the myosin layer line reflections during muscle contraction. J. Mol. Biol. 158, 637-684 (1982).
12. Lombardi, V. et al. Elastic distortion of myosin heads and repriming of the working stroke in muscle. Nature 374, 553-555 (1995).
13. Huxley, H. E., Stewart, A., Sosa, H. & Irving, T. X-ray diffraction measurements of the extensibility of actin and myosin filaments in contracting muscle. Biophys. J. 67, 2411-2421 (1994).
14. Wakabayashi, K. et al. X-ray diffraction evidence for the extensibility of actin and myosin filaments during muscle contraction. Biophys. J. 67, 2422-2435 (1994).
15. Ford, L. E., Huxley, A. F. & Simmons, R. M. The relation between stiffness and filament overlap in stimulated frog muscle fibres. J. Physiol. (Lond.) 311, 219-249 (1981).
16. Linari, M. et al. The stiffness of skeletal muscle in isometric contraction and rigor: the fraction of myosin heads bound to actin. Biophys. J. 74, 2459-2473 (1998).
17. Cooke, R. & Franks, K. All myosin heads form bonds with actin in rigor rabbit skeletal muscle. Biochemistry 19, 2265-2269 (1980).
18. Lovell, S. J., Knight, P. J. & Harrington, W. F. Fraction of myosin heads bound to thin filaments in rigor fibrils from insect flight and vertebrate muscles. Nature 293, 664-666 (1981).
19. Yagi, N. et al. Small-angle X-ray diffraction of muscle using undulator radiation from the Tristan main ring at KEK. J. Synchrotron Rad. 3, 305-312 (1996).
20. Higuchi, H., Yanagida, T. & Goldman, Y. E. Compliance of thin filaments in skinned fibers of rabbit skeletal muscle. Biophys. J. 69, 1000-1010 (1995).
21. Piazzesi, G. et al. Changes in the X-ray diffraction pattern from single intact muscle fibres produced by rapid shortening and stretch. Biophys. J. 68 (suppl.), 92-96 (1995).
22. Irving, M., Lombardi, V., Piazzesi, G. & Ferenczi, M. A. Myosin head movements are synchronous with the elementary force-generating process in muscle. Nature 357, 156-158 (1992).
23. Howard, J. & Spudich, J. A. Is the lever arm of myosin a molecular elastic element? Proc. Natl Acad. Sci. 93, 4462-4464 (1996).
24. Lombardi, V. & Piazzesi, G. The contractile response during steady lengthening of stimulated frog muscle fibres. J. Physiol. (Lond.) 431, 141-171 (1990).
25. Piazzesi, G., Linari, M., Reconditi, M., Vanzi, F. & Lombardi, V. Cross-bridge detachment and attachment following a step stretch imposed on active single frog muscle fibres. J. Physiol. (Lond.) 498, 3-15 (1997).
26. Nishiye, E., Somlyu, A. V., Törok, K. & Somlyo, A. P. The effect of MgADP on crossbridge kinetics: a laser flash photolysis study of guinea pig smooth muscle. J. Physiol. (Lond.) 460, 247-271 (1993).
27. Bershitsky, S. et al. Mechanical and structural properties underlying contraction of skeletal muscle fibers after partial EDC cross-linking. Biophys. J. 71, 1462-1474 (1996).
28. Towns-Andrews, E. et al. Time-resolved X-ray diffraction station: X-ray optics, detectors, and data acquisition. Rev. Sci. Instrum. 60, 2346-2349 (1989).
29. Irving, M. & Piazzesi, G. Motions of myosin heads that drive muscle contraction. News Physiol. Sci. 12, 249-254 (1997).
30. Merritt, E. A. & Bacon, D. J. Raster3D: Photorealistic molecular graphics. Methods Enzymol. 277, 505-524 (1997).