Ambiguities in mapping the active site of a conformationally dynamic enzyme by directed mutation: Role of dynamics in structure-function correlations in Escherichia coli adenylosuccinate synthetase

Journal of Biological Chemistry

Volumn 273, Issue 26, 1998, Pages 16000-16004

  Wang, W ^a   Gorrell, A ^a   Hou, Z ^a   Honzatko, R B ^a   Fromm, H J ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLOSUCCINATE SYNTHASE;

AMINO ACID SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME KINETICS; ESCHERICHIA COLI; GENE MAPPING; GENE MUTATION; MUTAGENESIS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ADENYLOSUCCINATE SYNTHASE; BINDING SITES; CHROMOSOME MAPPING; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032568813     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.26.16000     Document Type: Article

References (29)