Microsclerodermins C - E, antifungal cyclic peptides from the lithistid marine sponges Theonella sp. and Microscleroderma sp.

Tetrahedron

Volumn 54, Issue 13, 1998, Pages 3043-3056

  Schmidt, Eric W ^a   Faulkner, D John ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; CYCLOPEPTIDE; PEPTIDE DERIVATIVE;

ANTIFUNGAL ACTIVITY; ARTICLE; DRUG ISOLATION; DRUG STRUCTURE; MYCOSIS; PRIORITY JOURNAL; SPONGE (PORIFERA);

EID: 0032568379     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(98)00054-4     Document Type: Article

References (13)

1. 1. Bewley, C.A.; Faulkner, D.J. Angew. Chem. Intl. Ed. Engl. 1997, in press.
2. 2. Gunasekera, S.P.; Gunasekera, M.; Longler, R.E.; Schulte, G.K. J. Org. Chem. 1990, 55, 4912-4915.
3. 3. Kobayashi, M.; Tanaka, J.; Katori, T.; Masuura, M.; Kitagawa, I. Tetrahedron Letts. 1989, 30, 2963-2966.
4. 4. Kato, Y.; Fusetani, N.; Matsunaga, S.; Hashimoto, K. J. Am. Chem. Soc. 1986, 108, 2780-2781.
5. 5. Fusetani, N.; Matsunaga, S. Chem. Rev. 1993, 97, 1793-1806.
6. 6. Schmidt, E.W.; Bewley, C.A.; Faulkner, D.J. J. Org. Chem. In press.
7. 7. Bewley, C.A.; Holland, N.D.; Faulkner, D.J. Experientia 1996, 52, 716-722.
8. 8. Bewley, C.A.; Debitus, C.; Faulkner, D.J. J. Am. Chem. Soc. 1994, 116, 7631-7636.
9. 1H NMR signals were highly pH dependent.
10. b) Observed with trace TFA.
11. c) In basic solution, δ 167.9 ppm.
12. d) Not observed in basic or neutral solution.
13. 10. We found no record of natural products containing the p-ethoxy phenyl moiety in computer databases.