Uracil- and thymine-substituted thymidine and uridine derivatives

Tetrahedron Letters

Volumn 39, Issue 13, 1998, Pages 1835-1838

  Costa, Anna M ^a   Faja, Montserrat ^a   Farràs, Jaume ^a   Vilarrasa, Jaume ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; DEOXYURIDINE; THYMIDINE DERIVATIVE; THYMINE DERIVATIVE; URACIL DERIVATIVE; URIDINE DERIVATIVE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AMINO ACID ANALYSIS; ARTICLE; CHEMICAL BINDING; CYCLIZATION; NUCLEOTIDE SEQUENCE; PHOTOCHEMISTRY; REDUCTION; STEREOCHEMISTRY;

EID: 0032568327     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00100-2     Document Type: Article

References (28)

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19. +.
20. 10. Satisfactory microanalytical data have been obtained for the final products (1a-d and 2a-d).
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25. 14. For the use of 1,1′-thiocarbonyldiimidazole, step ii, see: Fox, J. J.; Wempen, I. Tetrahedron Lett. 1965, 643. Ruyle, W. V.; Shen, T. Y.; Patchett, A. A. J. Org. Chem. 1965, 30, 4353. For step iii, see: Kirschenheuter, G. P.; Zhai, Y.; Pieken, W. A. Tetrahedron Lett. 1994, 35, 8517.
26. 14. For the use of 1,1′-thiocarbonyldiimidazole, step ii, see: Fox, J. J.; Wempen, I. Tetrahedron Lett. 1965, 643. Ruyle, W. V.; Shen, T. Y.; Patchett, A. A. J. Org. Chem. 1965, 30, 4353. For step iii, see: Kirschenheuter, G. P.; Zhai, Y.; Pieken, W. A. Tetrahedron Lett. 1994, 35, 8517.
27. 15. Samples of 1a-d and 2a-d (1b and 1c as 5′-O-acetyl derivatives) were submitted to the National Cancer Institute, NIH, Bethesda, USA. The results, just received, show that none of them are sufficiently active against NCI standard cell lines.
28. 13C COSY and NOESY experiments).