A new approach for the determination of the absolute configuration of secondary alcohols by 1H NMR with O-substituted mandelate derivatives

Tetrahedron Letters

Volumn 39, Issue 13, 1998, Pages 1759-1762

  Chataigner, Isabelle ^a   Lebreton, Jacques ^a   Durand, Didier ^a   Guingant, André ^a   Villiéras, Jean ^a  

^a Centre National de la Recherche Scientifique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; MANDELIC ACID DERIVATIVE;

ARTICLE; CHIRALITY; DIASTEREOISOMER; ENANTIOMER; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY;

EID: 0032568272     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00059-8     Document Type: Article

References (26)

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25. 3. The reaction was carefully monitored by TLC (less than 1 h). Then, ether was added followed by 1N aq. HCl. The organic layer was washed with water and brine. The crude mandelate ester was used without further purification. Under these condtions, no epimerization and/or mandelate cleavage were detected.
26. 9. Data for MPA derivatives 14-17 taken from ref. 5a.