Asymmetric synthesis of epibatidine by use of a novel enantioselective sulfinate elimination reaction

Tetrahedron Letters

Volumn 39, Issue 9, 1998, Pages 1023-1024

  Jones, Clifford D ^a   Simpkins, Nigel S ^a   Giblin, Gerard M P ^b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; ALKENYL GROUP; EPIBATIDINE; SULFONE;

ARTICLE; CHEMICAL REACTION; CHIRALITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; REACTION ANALYSIS; STRUCTURE ANALYSIS;

EID: 0032567906     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)10693-1     Document Type: Article

References (3)

1. 1. Giblin, G. M. P.; Jones, C. D.; Simpkins, N. S. Synlett 1997, 589.
2. 2. For a somewhat related asymmetric dehydrobromination, see Amadji, M.; Vadecard, J.; Plaquevent, J C.; Duhamel, L.; Duhamel, P. J. Am. Chem. Soc., 1996, 118, 12483.
3. 3. For an alternative desymmetrisation of meso compounds related to 6, see Cossu, S.; De Lucchi, O.; Pasetto, P. Angew. Chem. Int. Ed. Engl. 1997, 36, 1504.