α2-Adrenergic receptor activation inhibits calcitonin gene-related peptide expression in cultured dorsal root ganglia neurons

Brain Research

Volumn 782, Issue 1-2, 1998, Pages 184-193

  Supowit, Scott C ^a   Hallman, Diane M ^a   Zhao, Huawei ^a   DiPette, Donald J ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

2 adrenergic receptor; Calcitonin gene related peptide; Gene expression; Nerve growth factor; Sensory neuron

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CALCITONIN GENE RELATED PEPTIDE; NERVE GROWTH FACTOR; YOHIMBINE;

ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION REGULATION; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SPINAL GANGLION; SPONTANEOUSLY HYPERTENSIVE RAT;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CELLS, CULTURED; DRUG COMBINATIONS; GANGLIA, SPINAL; MALE; NERVE GROWTH FACTORS; NEURONS; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA;

EID: 0032567772     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01277-8     Document Type: Article

References (48)

1. Amara S.G., Jonas V., Rosenfeld M.G., Ong E.S., Evans R.M. Alternative RNA processing in calcitonin gene expression generates mRNA encoding different polypeptides. Nature. 298:1982;240-244.
2. Amerini S., Rubino A., Mantelli L., Ledda F. α-Adrenoreceptor modulation of the efferent function of capsaicin-sensitive sensory neurons in guinea pig isolated atria. Br. J. Pharmacol. 105:1992;947-953.
3. Asimakis G.K., DiPette D.J., Conti V.R., Holland O.B., Zwischenberger J.R. Hemodynamic action of calcitonin gene-related peptide in the isolated rat heart. Life Sci. 41:1987;597-603.
4. Barber L.A., Vasko M.R. Activation of protein kinase C augments peptide release from rat sensory neurons. J. Neurochem. 67:1996;72-80.
5. Besson J.M., Chaouch A. Peripheral and spinal mechanisms of nociception. Physiol. Rev. 67:1987;67-186.
6. Bowman L.H., Rabin B., Schleisinger D. Multiple RNA cleavage pathways in mammalian cells. Nucleic Acids Res. 9:1981;4951-4960.
7. Burnstock G., Ralevic V. New insights into the local regulation of blood flow by perivascular nerves and endothelium. Br. J. Plastic Surg. 47:1994;527-543.
8. Chirgwin J.M., Przybyla A.E., MacDonald R.J., Rutter W.J. Isolation of biologically active ribonucleic acid from sources enriched with ribonuclease. Biochemistry. 18:1977;5294-5299.
9. DiPette D.J., Schwarzenberger K., Kerr N., Holland P.B. Dose dependent systemic and regional hemodynamic effects of calcitonin gene-related peptide. Am. J. Med. Sci. 297:1989;65-70.
10. D.J. DiPette, S.J. Wimalawansa, Calcium regulating hormones and cardiovascular function, in: J. Cross III, L.V. Aveoli (Eds.), Cardiovascular Actions of Calcitropic Hormones, CRC Press, Baltimore, 1994, pp. 239-252.
11. Dray A. Chemosensitivity of cultured dorsal root ganglia cells. News Physiol. Sci. 11:1996;288-292.
12. Gibson S.J., Polak J.M., Bloom S.R., Sabate I.M., Mulderry P.M., Evans R.M., Rosenfeld M.G. Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and eight other species. J. Neurosci. 12:1984;3101-3111.
13. Head R.J., Cassis L.A., Robinson R.L., Westfall D.P., Stizel R.E. Altered catecholamine contents in vascular and nonvascular tissues in genetically hypertensive rats. Blood Vessels. 22:1985;196-204.
14. b receptors to inhibition of peptide secretion from peripheral sensory neurons. J. Neurosci. 9:1989;657-666.
15. Holzer P. Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience. 24:1988;739-768.
16. Inaishi Y., Kashihara Y., Sakaguchi M., Numa H., Kuno J. Cooperative regulation of calcitonin gene-related peptide levels in rat sensory neurons via their central and peripheral processes. J. Neurosci. 12:1992;518-524.
17. Kawasaki H., Nuki C., Saito A., Takasaki K. Adrenergic modulation of calcitonin gene-related peptide (CGRP) containing nerve-mediated vasodilation in the rat mesenteric resistance vessel. Brain Res. 506:1990;287-290.
18. Kruger L., Silverman J.D., Mantyk P.W., Sternini C., Becha N.C. Peripheral patterns of calcitonin gene-related peptide general somatic sensory innervation: cutaneous and deep terminations. J. Comp. Neurol. 280:1989;291-302.
19. Lembeck F., Holzer P. Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation. Arch. Pharmacol. 310:1979;175-183.
20. Lindsay R.M. Nerve growth factors (NGF, BDNG) enhance axonal regeneration but are not required for survival of adult sensory neurons. J. Neurosci. 8:1988;2394-2405.
21. Lindsay R.M., Lockett C., Sternberg J., Winter J. Neuropeptide expression in cultures of adult sensory neurons: modulation of substance P and calcitonin gene-related peptide levels by nerve growth factor. Neuroscience. 33:1989;53-65.
22. MacDonald A., Kelly J., Dettmar W. Pre- and post-junctional α-adrenoceptor-mediated responses in the rat gastric fundus in vitro. J. Pharm. Pharmacol. 42:1990;752-757.
23. 2-adrenoceptor-subtype function. Trends Pharmacol. Sci. 18:1997;211-219.
24. Marti E., Gibson S.J., Polak J.M., Facer P., Springall D.R., Van Aswegen G., Aitchison M., Koltzenburg M. Ontogeny of peptide- and amine-containing neurones in motor, sensory and autonomic regions of rat and human spinal cord, dorsal root ganglia and rat skin. J. Comp. Neurol. 266:1987;332-359.
25. 2-adrenoceptors and opiate receptors. Eur. J. Pharmacol. 163:1989;15-23.
26. Messina A., Bertram J.F., Bakhle Y.S., Bell C. Decreased developmental cell death in sympathetic and spinal sensory nervous systems of the Kyoto spontaneously hypertensive rat. J. Hypertens. 14:1996;1111-1115.
27. Mulderry P.K. Neuropeptide expression by newborn and adult rat sensory neurons in culture: effects of nerve growth factor and other neurotrophic factors. Neuroscience. 59:1994;673-688.
28. Mulderry P.K., Ghatei M.A., Rodrigo J., Allen J.M., Rosenfeld M.G., Polak J.M., Bloom S.R. Calcitonin gene-related peptide in cardiovascular tissues of the rat. Neuroscience. 14:1985;947-954.
29. Nicholas A.P., Pieribone U., Hokfelt T. Distribution of mRNas for α-2 adrenergic receptor subtypes in rat brain: an in situ hybridization study. J. Comp. Neurol. 328:1993;575-594.
30. Ono H., Meskima A., Ono S., Fukuda H., Vasko M.R. Inhibitory effects of clonidine and tizanidine on release of substance P from slices of rat spinal cord and antagonism by α-adrenergic receptor antagonists. Neuropharmacology. 30:1991;585-589.
31. H.P. Rang, S.J. Bevan, A. Dray, Nociceptive peripheral neurones: cellular properties, in: P.D. Wall, R. Melzack (Eds.), Textbook of Pain, Churchill Livingstone, Edinburgh, 1994, pp. 57-78.
32. Raymond J.R., Hnatowich M., Lefkowitz R.J., Caron M.G. Adrenergic receptors: models for regulation of signal transduction processes. Hypertension. 15:1990;119-131.
33. Reddy S.V.R., Maderdent J.L., Yaksh T.L. Spinal cord pharmacology of adrenergic agonist-mediated antinociception. J. Pharm. Expt. Ther. 213:1980;525-533.
34. Reddy S.V.R., Yaksh T.L. Spinal noradrenergic terminal system mediates antinociception. Brain Res. 189:1980;391-401.
35. J. Sambrook, E.F. Fritsch, T. Maniatis, Molecular Cloning - A Laboratory Manual, 2nd edn., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1989.
36. Supowit S.C., Christensen M.D., Westlund K.N., Hallman D.M., DiPette D.J. Dexamethasone and activators of the protein kinase A and C signal transduction pathways regulate neuronal calcitonin gene-related peptide expression and release. Brain Res. 686:1995;77-86.
37. Supowit S.C., Gururaj A., Ramana C.V., Westlund K.N., DiPette D.J. Enhanced neuronal expression of calcitonin gene-related peptide in mineralocorticoid-salt hypertension. Hypertension. 25:1995;1333-1338.
38. Supowit S.C., Hallman D.M., Zhao H., DiPette D.J. Bradykinin regulates neuronal calcitonin gene-related peptide expression. Hypertension. 26:1995;564.
39. Supowit S.C., Ramara C.V., Westlund K.N., DiPette D.J. Calcitonin gene-related peptide gene expression in the spontaneously hypertensive rat. Hypertension. 21:1993;1010-1014.
40. Supowit S.C., Zhao H., Hallman D.M., DiPette D.J. Calcitonin gene-related peptide is a depressor of derorycorticosterone-salt hypertension in the rat. Hypertension. 29:1997;945-950.
41. Supowit S.C., Zhao H., Wang D.H., DiPette D.J. Regulation of calcitonin gene-related peptide expression: role of increased blood pressure. Hypertension. 26:1995;1177-1180.
42. Torebjork E., Wahren L., Wallin G., Hallin R., Koltzenburg M. Noradrenaline-evoked pain in neuralgia. Pain. 63:1995;11-20.
43. 2 enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in culture. J. Neurosci. 14:1994;4987-4997.
44. Vedder H., Affolter H.U., Otten U. NGF regulates tackykinin gene expression in rat sensory neurons during postnatal development. Neuropeptides. 24:1993;351-357.
45. Westlund K.N., DiPette D.J., Carson J., Holland O.B. Decreased spinal cord content of calcitonin gene-related peptide in the spontaneously hypertensive rat. Neurosci. Lett. 131:1991;183-186.
46. Wimalawansa S.J. Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials. Endocrine Rev. 17:1996;533-585.
47. Wimalawansa S.J., MacIntyre I. Calcitonin gene-related peptide and its specific binding sites in the cardiovascular system of the rat. Int. J. Cardiol. 20:1988;29-33.
48. T.L. Yaksh, J. Bailey, D.R. Roddy, G.J. Harty, Peripheral release of substance P from primary afferents, in: R. Dubner, G.F. Gebhart, M.R. Bond (Eds.), Proceedings from the 5th World Congress on Pain, Elsevier, Amsterdam, 1988, pp. 51-54.