Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in goldfish cerebellum: Neurochemical and immunocytochemical analysis

Brain Research

Volumn 782, Issue 1-2, 1998, Pages 105-112

  Lucchi, R ^a   Notari, S ^a   Pierantozzi, S ^a   Barnabei, O ^a   Villani, L ^a   Poli, A ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

1 methyl 4 phenyl 1,2,3,6 tetrahydropyridine; Amino acidic neurotransmitter; Catecholamine; Goldfish brain; Neurotoxicity

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 4 AMINOBUTYRIC ACID; CATECHOLAMINE; CHOLINE ACETYLTRANSFERASE; DIZOCILPINE; DOPAMINE; DOPAMINE BETA MONOOXYGENASE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMATE AMMONIA LIGASE; GLUTAMATE DECARBOXYLASE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; MAZINDOL; NORADRENALIN; ORNITHINE DECARBOXYLASE; PARGYLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CEREBELLUM; CONTROLLED STUDY; GOLDFISH; IMMUNOCYTOCHEMISTRY; MEDULLA OBLONGATA; NEUROCHEMISTRY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; AMINO ACIDS; ANIMALS; CATECHOLAMINES; CEREBELLUM; ENERGY METABOLISM; GOLDFISH; IMMUNOHISTOCHEMISTRY; NEURONS; OSMOLAR CONCENTRATION; PURINES;

EID: 0032567699     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01272-9     Document Type: Article

References (43)

1. Atkinson D.E. The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. Biochemistry. 7:1968;4030-4034.
2. Barbeau A., Dallaire L., Buu N.T., Veilleux F., Boyer H., De Lanney L.E., Irwin I., Langston E.B., Langston J.W. New amphibian models for the study of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Life Sci. 36:1985;1125-1134.
3. Baudry M., Lynch G., Gall C. Induction of ornithine decarboxylase as a possible mediator of seizure-induced changes in genomic expression in rat hippocampus. J. Neurosci. 6:1996;3430-3435.
4. Bocchetta A., Piccardi M.P., Del Zompo M., Pintus S., Corsini G.U. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Correspondence of its binding sites to monoamine oxidase in rat brain, and inhibition of dopamine oxidative deamination in vivo and in vitro. J. Neurochem. 45:1985;673-676.
5. Burns R.S., Chiueh C.C., Markey S.P., Ebert M.H., Jacobowitz D.M., Kopin I.J. A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. Sci. U.S.A. 80:1983;4546-4550.
6. Chiba K., Trevor A., Castagnoli N. jr. Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase. Biochem. Biophys. Res. Commun. 120:1984;574-578.
7. Contestabile A., Friz T., Caravaggio M.V. Disappearance and recovery of catecholamine innervation in brain regions of adult goldfish following 6-hydroxydopamine treatment. Neurosci. Lett. 14:1979;333-337.
8. Cuñha R.A., Sebastião A.N. Separation of adenosine triphosphate and its degradation products in innervated muscle of the frog by reverse phase high-performance liquid chromatography. Chromatographia. 28(11-12):1993;610-612.
9. + uptake into synaptic dopamine vesicles: Possible involvement in MPTP neurotoxicity. Br. J. Pharmacol. 109:1993;411-414.
10. Eng L.F. Glial fibrillary acidic protein (GFAP): the major protein of glial intermediate filaments in differentiated astrocytes. J. Neuroimmunol. 8:1985;203-214.
11. Goping G., Pollard H.B., Adeyemo O.M., Kuijpers G.A.J. Effect of MPTP on dopaminergic neurons in the goldfish brain: a light and electron microscope study. Brain Res. 687:1995;35-52.19.
12. Hallman H., Olson L., Jonsson G. Neurotoxicity of the meperidine analogue MPTP in brain catecholamine neurons in the mouse. Eur. J. Pharmacol. 97:1984;133-136.
13. Hazell A.S., Itzhak Y., Liu H., Norenberg M.D. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) decreases glutamate uptake in cultured astrocytes. J. Neurochem. 68:1997;2216-2219.
14. Heikkila R.E., Hess A., Duvoisin R.C. Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Science. 224:1984;1451-1453.
15. Heikkila R.E., Manzino L., Cabbat F.S., Duvoisin R.C. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by monoamine oxidase inhibitors. Nature. 311:1984;467-469.
16. Hill D.W., Walters F.H., Wilson T.D., Stuard J.D. High performance liquid chromatographic determination of amino acid in the picomole range. Anal. Chem. 51:1979;1338-1341.
17. + by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin MPTP. Eur. J. Pharmacol. 106:1984;455-456.
18. Javitch A., D'Amato R.J., Strittmatter S.M., Snyder S.H. Parkinsonism inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc. Natl. Acad. Sci. U.S.A. 82:1985;2173-2177.
19. Kotchabhakdi N. Functional circuitry of the goldfish cerebellum. J. Comp. Physiol. 112:1976;47-73.
20. Langston W.J., Forno L.S., Rebert C.S., Irwin I. Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the squirrel monkey. Brain Res. 292:1984;390-394.
21. Levi G., Gordon R.D., Gallo V., Wilkin G.P., Balazs R. Putative amino acid transmitters in the cerebellum: I. Depolarization-induced release. Brain Res. 239:1982;425-445.
22. Lloyd K.G., Möhler H., Heitz Ph., Bartholini G. Distribution of choline acetyltransferase and glutamate decarboxylase within the substantia nigra and in other brain regions from control and parkinsonian patients. J. Neurochem. 25:1974;789-795.
23. Lowry O.H., Rosenbroug N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
24. Marini A.M., Schwartz J.P., Hopin I.J. The neurotoxicity of 1-methyl-4-phenylpyridinium in cultured cerebellar granules cells. J. Neurosci. 9:1989;3665-3672.
25. Marini A.M., Lipsky H., Schwartz J.P., Kopin I.J. Accumulation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine in cultured cerebellar astrocytes. J. Neurochem. 58:1992;1250-1258.
26. Mayer G.S., Shoup R.E. Simultaneous multiple electrode liquid chromatographic-electrochemical assay for catecholamines, indoleamines and metabolites in brain tissue. J. Chromatogr. 225:1983;533-544.
27. P.L. McGeer, J.C. Eccles, E. McGeer, Anatomical distribution of GABA pathways in brain, in: Molecular Neurobiology of the Mammalian Brain, Plenum, New York, 1978, pp. 202-209.
28. Mytilineou C., Friedmam L. Studies on the metabolism and toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in cultures of embryonic rat mesencephalon. J. Neurochem. 51:1988;750-755.
29. O'Callaghan J.P., Seidler F.J. 1-Methyl-4phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced astrogliosis does not require activation of ornithine decarboxylase. Neurosci. Lett. 148:1992;105-108.
30. Patel A.J., Hunt A., Tahourdin C.S.M. Regional development of glutamine synthetase activity in rat brain and its association with the differentiation of astrocytes. Dev. Brain Res. 8:1983;31-37.
31. Poli A., Guarnieri T., Facchinetti F., Villani L. Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in goldfish brain. Brain Res. 534:1990;45-50.
32. Poli A., Lucchi R., Gandolfi O., Barnabei O. Spontaneous recovery of MPTP-damaged catecholamine systems in goldfish brain areas. Brain Res. (Amsterdam). 585:1992;128-134.
33. Pollard H.B., Dhariwal K., Adeyemo O.M., Markey C.J., Caohuy H., Levine M., Markey S., Youdim M.H.B. A parkinsonian syndrome induced in the goldfish by the neurotoxin MPTP. FASEB J. 6:1992;3108-3116.
34. Sandberg M., Ward H.K., Bradford H.F. Effects of cortico-striate pathway lesion on the activities of enzymes involved in synthesis and metabolism of amino acid neurotransmitters in the striatum. J. Neurochem. 44:1985;42-47.
35. + neurotoxicity by N-methyl-D-aspartate antagonists. Brain Res. 586:1992;203-207.
36. Singer T.P., Castagnoli N. jr., Ramsay R.R., Trevor A.J. Biochemical events in the development of parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J. Neurochem. 49:1987;1-8.
37. + by dopamine neurons is required for MPTP toxicity: studies in brain synaptosomes and PC-12 cells, in: S.P. Markey, N. Castagnoli Jr., A.J. Trevor, I.J. Kopine (Eds.), MPTP: A Neurotoxin Producing a Parkinsonian Syndrome, Academic Press, Orlando, 1986, pp. 191-201.
38. Takada M., Sugimoto T., Hattori T. Cerebellar Purkinje cell: another neuronal basis of MPTP-induced parkinsonism. Soc. Neurosci. Abstr. 14:1988;1026.
39. Takada M., Sugimoto T., Hattori T. MPTP neurotoxicity to cerebellar Purkinje cells in mice. Neurosci. Lett. 150:1993;49-52.
40. Villani L., Poli A., Bissoli R., Barnabei O. Neurotoxic effect of 1-methyl-4-phenylpyridinium ion on dopaminergic neurons of the retina of goldfish. Neurosci. Lett. 7:1988;4115-4128.
41. Villani L., Migani P., Poli A., Niso R., Contestabile A. Neurotoxic effect of kainic acid on ultrastructure and GABAergic parameters in the goldfish cerebellum. Neuroscience. 7:1982;2515-2524.
42. Vyas I., Heikkila R.E., Nicklas W.J. Studies on the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: inhibition of NADH-linked substrate oxidation by its metabolite 1-methyl-4-phenylpyridinium. J. Neurochem. 46:1986;1501-1507.
43. Zuddas A., Oberto G., Vaglini F., Fascetti F., Fornai F., Corsini G.U. MK-801 prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in primates. J. Neurochem. 59:1992;733-739.