Thioperamide, a histamine H3 receptor antagonist, suppresses NPY-but not Dynorphin A-induced feeding in rats

Regulatory Peptides

Volumn 75-76, Issue , 1998, Pages 373-376

  Itoh, Etsuro ^a   Fujimiya, Mineko ^b   Inui, Akio ^c  

^a UBE INDUSTRIES LTD   (Japan)

^b SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^c KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Dynorphin A; Feeding; Histamine H3 receptor; Intracerebroventricular; Neuropeptide Y; Rat pancreatic polypeptide; Thioperamide

Indexed keywords

DYNORPHIN A; DYNORPHIN A DERIVATIVE; HISTAMINE H3 RECEPTOR ANTAGONIST; NEUROPEPTIDE Y; PANCREAS POLYPEPTIDE; THIOPERAMIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FOOD INTAKE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; DYNORPHINS; EATING; HISTAMINE ANTAGONISTS; INJECTIONS, INTRAVENTRICULAR; MALE; NEUROPEPTIDE Y; PANCREATIC POLYPEPTIDE; PEPTIDE YY; PIPERIDINES; RATS; RATS, WISTAR; RECEPTORS, HISTAMINE H3; RECEPTORS, OPIOID, KAPPA;

EID: 0032566831     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(98)00090-1     Document Type: Article

References (24)

1. Clark J.T., Kalra P.S., Crowley W.R., Kalra S.P. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology. 115:1984;427-429.
2. Morley J.E., Levine A.S., Grace M., Kneip J. Peptide YY (PYY), a potent orexigenic agent. Brain Res. 341:1985;200-204.
3. Heilig M., Vecsei L., Wahlestedt C., Allig C., Widerlov E. Effects of centrally administered neuropeptide Y (NPY) and NPY13-16 on the brain monoaminergic systems of the rat. J Neural Transm Gen Sect. 79:1990;193-208.
4. Myers R.D., Lankford M.F., Paez X. Norpepinephrine, dopamine, and 5-HT release from perfused hypothalamus of the rat during feeding induced by neuropeptide Y. Neurochem Res. 17:1992;1123-1132.
5. Matos F.F., Guss V., Korpinen C. Effects of neuropeptide Y (NPY) and [D-Trp32] NPY on monoamine and metabolite levels in dialysates from rat hypothalamus during feeding behavior. Neuropeptide. 30:1996;391-398.
6. Myers R.D., Lankford M.F., Roscoe A.K. Neuropeptide Y perfused in the preoptic area of rats shifts extracellular efflux of dopamine, norepinephrine, and serotonin during hypothermia and feeding. Neurochem Res. 21:1996;637-648.
7. Hagan M.M., Moss D.E. Effect of naloxone and antidepressants on hyperphagia produced by peptide YY. Pharmacol Biochem Behav. 45:1993;941-944.
8. Hagan M.M., Moss D.E. Suppression of peptide YY-induced hyperphagia by terbutaline. Pharmacol Biochem Behav. 46:1993;679-681.
9. Hagan M.M., Moss D.E. Differential effects of Tyr-MIF-1, MIF-1, and naloxone on peptide YY-induced hyperphagia. Peptides. 15:1994;243-245.
10. Itoh E., Fujimiya M., Inui A. A role of the histaminergic system on PYY-induced feeding behavior in rats. Regul Pept. 71:1997;222.
11. Itoh E, Fujimiya M, Inui A. Thioperamide, a histamine H3 receptor antagonist, powerfully supresses PYY-induced food intake in rats. Biol Psychiatry 1998:in press.
12. Chavkin C., James I.F., Goldstein A. Dynorphin is a specific endogenous ligand of the kappa opioid receptor. Science. 215:1982;413-415.
13. Morley J.E., Levine A.S. Dynorphin-(1-13) induces spontaneous feeding in rats. Life Sci. 29:1981;1901-1903.
14. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates, 2nd ed. Australia: Academic Press, 1986.
15. Nakajima M., Inui A., Teranishi A., Miura M., Hirosue Y., Okita M., Himori N., Baba S., Kasuga M. Effects of PP family peptide on feeding and learning behavior in mice. J Pharmacol Exp Ther. 268:1994;1010-1014.
16. Itoh Y., Oishi R., Nishibori M., Saeki K. Characterization of histamine release from the rat hypothalamus as measured by in vivo microdialysis. J Neurochem. 56:1991;769-774.
17. Mochizuki T., Yamatodani A., Okakura K., Takemura M., Inagaki N., Wada H. In vivo release of neuronal histamine in the hypothalamus of rats measured by microdialysis. Naunyn-Schmiedeberg's Arch Pharmacol. 343:1991;190-195.
18. Sakata T., Yoshimatsu H., Kurokawa M. Hypothalamic neuronal histamine: Implications of its homeostatic control of energy metabolism. Nutrition. 13:1997;403-411.
19. Schlicker E., Malinowska B., Kathmann M., Gothert M. Modulation of neurotransmitter release via histamine H3 heteroreceptors. Fund Clin Pharmacol. 8:1994;128-137.
20. Ohkubo T., Shibata M., Inoue M., Kaya H., Takahashi H. Regulation of substance P release mediated via prejunctional histamine H3 receptors. Eur J Pharmacol. 273:1995;83-88.
21. Naruse T., Ishii R. Relationship between histamine receptors in the brain and diazepam-induced hyperphagia in rats. Pharmacol Biochem Behav. 51:1995;923-927.
22. Blomgvist A.G., Herzog H. Y-receptor subtypes - how many more? Trends Neurosci. 20:1997;294-298.
23. Inui A., Fujimiya M., Sakai T. Genetically engineered animal models of obesity and body weight regulation. Curr Top Pharmacol. 3:1997;123-135.
24. Inui A., Okita M., Nakajima M., Momose K., Ueno N., Teranishi A., Miura M., Hirosue Y., Sano K., Sato M., Watanabe M., Sakai T., Watanabe T., Ishida K., Silver J., Baba S., Kasuga M. Anxiety-like behavior in transgenic mice with brain expression of Neuropeptide Y. Proc Assoc Am Phys. 110:1998;171-182.