Abnormal regulation of the Ke 6 gene, a new 17β-hydroxysteroid dehydrogenase in the cpk mouse kidney

Molecular and Cellular Endocrinology

Volumn 143, Issue 1-2, 1998, Pages 9-22

  Ramirez, Sylvia ^a   Fomitcheva, Ioulia ^a   Aziz, Nazneen ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

cpk cells; Ke 6 gene; Promoter activity

Indexed keywords

NUCLEAR PROTEIN; TESTOSTERONE 17BETA DEHYDROGENASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; DNA SEQUENCE; DNA TRANSFECTION; ENHANCER REGION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE MUTATION; KIDNEY; KIDNEY POLYCYSTIC DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING;

17-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; BASE SEQUENCE; CELL LINE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; KIDNEY; MICE; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); SEQUENCE ANALYSIS, DNA;

EID: 0032566362     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(98)00143-9     Document Type: Article

References (30)

1. Andersson, S., Moghrabi, N., 1997. Physiology and molecular genetics of 17β-hydroxysteroid dehydrogenases. Steroids 62, 143-147.
2. Avner, E., Sweeney, W., Piesco, N., Ellis, D., 1984. A new model of glucocorticoid-induced metanephric maldevelopment. Experimentia 40, 489-490.
3. Aziz, N., Maxwell, M., St.-Jacques, B., Brenner, B., 1993. Downregulation of Ke 6, a novel gene encoded within the major histocompatibility complex, in murine polycystic kidney disease. Mol. Cell. Biol. 13, 1847-1853.
4. Aziz, N., Maxwell, M., Brenner, B., 1994. Coordinate regulation of 11 βHSD and Ke 6 genes in cpk mouse: Implications for steroid metabolic defect in PKD. Am. J. Physiol. 267, 791-797.
5. Aziz, N., Nearing, J., Kriedberg, J., Donovan, M., 1995a. Antisense oligonucleotide mediated inhibition of Ke 6 gene expression induces cysts in embryonic kidneys in organ cultures. J. Am. Soc. Nephrol. 6, 690.
6. Aziz, N., 1995b. Animal models of polycystic kidney disease. Bioessays 17, 703-712.
7. Aziz, N., Donovan, M., Nearing, J., Naray Fejes-Toth, A, 1996a. Involvement of 11β hydroxysteroid dehydrogenase-1 in polycystic kidney disease: Implications of regulation by the Ke 6 gene. J. Am. Soc. Nephrol. 7, 1743.
8. Aziz, N., Brown, D., Lee, W-S., Fejes-Toth, N., 1996b. Aberrant 11β hydroxysteroid dehydrogenase-I activity in the cpk mouse: Implications for regulation by the Ke 6 gene. Endocrinology 137 (12), 5581-5588.
9. Brown, M., McCormack, M., Zinn, K., Farrell, M., Bikel, I., Livingston, D., 1986. A recombinant murine retrovirus for simian virus 40 large T cDNA transforms mouse fibroblast to anchorage-independent growth. J. Virol. 60, 290-293.
10. Crocker, J., Stewart, A., Sparling, J., Bruneau, M., 1976. Steroid-induced polycystic kidneys in the newborn rat. Am. J. Pathol. 82, 373-380.
11. Crocker, J.F.S., Blecher, S.R., Givner, M.C., McCarthy, S.C., 1990. Polycystic kidney and liver disease and corticosterone changes in the cpk mouse. Kidney Int. 37, 901-908.
12. Dignam, J., Lebovitz, R., Roeder, R., 1983. Accurate transcription initiation by RNA polymerase H in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475-1489.
13. Feinberg, A., Vogelstein, B., 1983. A technique for radiolabeling DNA fragments to high specific activity. Anal. Biochem. 13, 6-13.
14. Filmer, R., Carone, F., Rowland, R., Babcock, J., 1973. Adrenal corticosteroid-induced renal cystic disease in the newborn hamster. Am. J. Pathol. 72, 461-472.
15. Fomitcheva, J., Baker, M., Anderson, E., Lee, G., Aziz, N., 1998. Characterization of Ke 6, a new 17β-hydroxysteorid dehydrogenase and its expression in gonadal tissues, (submitted).
16. Gorman, C., Moffat, L., Howard, B., 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2, 1044-1051.
17. Low, S., Assaad, S., Rajan, K., Chapman, K., Edwards, C., Seckl, J., 1993. Regulation of 11βHSD by sex steroids in vivo: Further evidence for the existence of a second dehydrogenase in rat kidney. J. Endocrinol. 139, 27-35.
18. Maniatis, T., Fritsch, E., Sambrook, J., 1982. Molecular Cloning: A laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
19. Maxwell, M., Nearing, J., Aziz, N., 1995. Ke 6 gene: Sequence and organization and aberrant regulation in murine polycystic kidney disease. J. Biol. Chem. 270, 25213-25219.
20. McDonald, A., Crocker, J., Digout, S., McCarthy, S., Blecher, S., Cole, D., 1990. Glucocorticoid-induced polycystic kidney disease - a threshold trait. Kidney Int. 37, 901-908.
21. McManus, J., Fischbarg, J., Sun, A., Hebert, S., Strange, K., 1993. Laser light scattering system for studying cell volume regulation and membrane transport processing. Am. J. Physiol. 265, 562-570.
22. Miskimins, K., Roberts, M., McClelland, A., Ruddle, F., 1985. Use of a protein-blotting procedure and a specific DNA probe to identify nuclear proteins that recognize the promoter region of the transferrin receptor gene. Proc. Natl. Acad. 82, 6741-6744.
23. Perey, D., Herdman, R., Good, R., 1967. Polycystic renal disease: A new experimental model. Science 158, 494-496.
24. Piao, Y-S., Peltoketo, H., Vihko, P., Vihko, R., 1997. The proximal promoter region of the gene encoding human 17β-hydroxysteroid dehydrogenase type 1 contains GATA, AP-2 and Sp1 responsive elements: analysis of promoter function in choriocarcinoma cells. Endocrinology 138, 3417-3425.
25. Reeders, S., 1992. Multilocus polycystosis disease. Nat. Genet. 1, 235-237.
26. St.-Jacques, B., Han, T.-H., MacMurray, A., And Shin, H.-S., 1990. A putative transmembrane protein with histidine-rich charge clusters encoded in the H-2K/tw5 region of mice. Mol. Cell. Biol. 10, 138-145.
27. Taub, M., Gordon, L., Martin, G., Kleinman, H., 1990. Altered basement membrane protein biosynthesis by primary cultures of cpk/cpk mouse kidney. Kidney Int. 37, 1090-1097.
28. Welling, L., Grantham, J., 1991. Cystic and developmental diseases of the kidney. In: Brenner, B., Rector, F. (Eds.), The Kidney, vol. II. Saunders, Philadelphia, pp. 1657-1694.
29. Wet, J., Wood, K., DeLuca, M., Helinski, D., Subramani, S., 1987. Firefly luciferase gene: Structure and expression in mammalian cells. Mol. Cell. Biol. 7, 725-737.
30. Whitehouse, R., Lendon, R., Lendon, M., 1980. Renal polycystosis in the rat induced by prednisolone tertiary butyl acetate. Experientia 36, 244-245.