Blood glutamate levels in patients with motor neuron disease

Clinica Chimica Acta

Volumn 273, Issue 2, 1998, Pages 195-200

  Babu, G Nagesh ^a   Bawari, M ^a   Mathur, V N ^a   Kalita, J ^a   Misra, U K ^a  

^a SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Amyotrophic lateral sclerosis; Excitotoxins; Glutamate; Motor neuron disease; Progressive bulbar palsy

Indexed keywords

EXCITOTOXIN; GLUTAMIC ACID;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FACIAL NERVE PARALYSIS; FEMALE; HUMAN; MALE; MOTOR NEURON DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; BULBAR PALSY, PROGRESSIVE; FEMALE; GLUTAMIC ACID; HUMANS; MALE; MIDDLE AGED; MOTOR NEURON DISEASE;

EID: 0032565714     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-8981(98)00039-4     Document Type: Article

References (23)

1. [1] Tandan R, Bradley WG. Amytrophic lateral sclerosis: part 1. Clinical features, pathology and ethical issues in management. Ann Neurol 1985;18:271-80.
2. [2] Tandan R, Bradley WG. Amyotrophic lateral sclerosis: part 2. Etiopathogenesis. Ann Neurol 1985;18:419-31.
3. [3] Young AB, Penney JB, Darith GW. Glutamate or aspartate as a possible neurotransmitter of the cerebral corticofugal fibers in the monkey. Neurology 1983;33:1513-6.
4. [4] Fonnum F. Glutamate - a neurotransmitter in mammalian brain. J Neurochem 1984;42:1-11.
5. [5] O'Brien RJ, Fischbach GD. Modulation of embryonic chick motorneuron glutamate sensitivity by interneurons and agonists. J Neurosci 1986;6:3290-6.
6. [6] Olney JW. Inciting excitotoxic cytocide among central neurons. Adv Exp Biol Med 1986;203:631-45.
7. [7] Spencer PS, Roy DN, Ludolf A et al. Lathyrism: Evidence for role of the neuroexcitatory amino acid BoAA. Lancet 1986;2:1066-7.
8. [8] Spencer PS, Nunn PB, Hugon J. Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin. Science 1987;237:517-22.
9. [9] Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1988;1:623-34.
10. [10] Plaitakis A, Barl S, Yahr MD. Abnormal glutamate metabolism in adult-onset degenerative neurological disorder. Science 1982;216:193-6.
11. [11] Plaitakis A, Carcmaio JT. Abnormal glutamate metabolism in ALS. Ann Neurol 1985;18:165.
12. [12] Plaitakis A, Caroscio JT. Abnormal glutamate metabolism in amyotrophic lateral sclerosis. Ann Neurol 1987;22:575-9.
13. [13] Plaitakis A, Constantakakis E, Smith J. The neuroexcitotoxic amino acids glutamate and aspartate are altered in the spinal cord and brain in amyotrophic lateral sclerosis. Ann Neurol 1988;24:446-9.
14. [14] Plaitakis A. Glutamate dysfunction and selective motor neuron degeneration in amyotrophic lateral sclerosis: A hypothesis. Ann Neurol 1990;28:3-8.
15. [15] Plaitakis A. Altered glutamatergic mechanisms and selective motor neuron degeneration in amyotrophic lateral sclerosis: Possible role of glycine. In: Rowland LP, editor. Advances in Neurology Vol 56. Amyotrophic lateral sclerosis and other motor neuron diseases. New York: Raven Press, 1991:319-26.
16. [16] Rothstein JD, Martin LJ, Kunel RW. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N Engl J Med 1992;326:1464-8.
17. [17] Battaglioli G, Martin DL, Plummer D et al. Synaptosomal glutamate uptake declines progressively in the spinal cord of a mutant mouse with motor neuron disease. J Neurochem 1993;60:1567-9.
18. [18] Babu GN, Bawari M, Ali MM. Lipid peroxidation potential and antioxidant status of circumventricular organs of rat brain following neonatal monosodium glutamate. Neurotoxicology 1994;15:773-7.
19. [19] Bawari M, Babu GN, Ali MM et al. Lactate dehydrogenase and glutamate dehydrogenase activities in the circumventricular organs of rat brain following neonatal monosodium glutamate. Experientia 1993;49:1092-4.
20. [20] Bawari M, Babu GN, Ali MM et al. Effect of neonatal monosodium glutamate on lipid peroxidation in adult rat brain. Neuroreport 1995;6:650-2.
21. [21] Bawari M, Babu GN, Ali MM et al. Effect of neonatal monosodium glutamate in glutamate dehydrogenase and aminotransferase activities in circumventricular organs of rat brain. Amino Acids 1995;8:393-5.
22. [22] Eubanks JH, Puranam RS, Kleckner NW et al. The gene encoding the glutamate receptor subunit Glu R5 is located in human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis. Proc Natl Acad Sci USA 1993;90:178-82.
23. [23] Rosen DR, Siddiqui T, Patterson D et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993;363:59-62.