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Volumn 120, Issue 11, 1998, Pages 2599-2605

Structures of the Cu(I) and Cu(II) forms of amine oxidases from X-ray absorption spectroscopy

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); COPPER ION;

EID: 0032565069     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja970312a     Document Type: Article
Times cited : (62)

References (51)
  • 3
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    • (1994) Metal Ions in Biological Systems , vol.30 , pp. 361-403
    • Knowles, P.F.1    Dooley, D.M.2
  • 25
    • 0038881940 scopus 로고
    • King, R. B., Ed., Wiley: Chichester
    • (b) Dooley, D. M. In Encyclopedia Inorg. Chem., vol. 2, King, R. B., Ed., Wiley: Chichester, 1994; pp 905-924.
    • (1994) Encyclopedia Inorg. Chem. , vol.2 , pp. 905-924
    • Dooley, D.M.1
  • 27
    • 2642683305 scopus 로고    scopus 로고
    • BPAO was purified by minor modifications of the procedures described in ref 5c
    • BPAO was purified by minor modifications of the procedures described in ref 5c.
  • 41
    • 2642615486 scopus 로고    scopus 로고
    • note
    • During turnover, reducing equivalents are derived from substrate and transferred to copper from reduced TPQ. Electrons from dithionite may be transferred to copper via TPQ as well because dithionite can reduce TPQ in most amine oxidases. At this time we cannot rule out the possibility that there may be structural differences between the Cu(I) sites in dithionite-reduced versus substrate-reduced amine oxidases. Owing to the reversible redox partition (Scheme 1 ) the substrate-reduced form is difficult to probe by XAS, especially because the Cu(II) state is favored at low temperatures. The Cu(I) state is stabilized by the addition of cyanide and other exogenous ligands, and structural studies of this complex are underway.
  • 42
    • 1542310862 scopus 로고
    • Thorp, H. H., Pecoraro, V. L., Eds.; American Chemical Society: Washington, DC and references therein
    • Murthy, N. N.; Karlin, K. D. In Mechanistic Bioinorganic Chemistry; Thorp, H. H., Pecoraro, V. L., Eds.; American Chemical Society: Washington, DC 1995; pp 165-193 and references therein.
    • (1995) Mechanistic Bioinorganic Chemistry , pp. 165-193
    • Murthy, N.N.1    Karlin, K.D.2
  • 49
    • 0000716397 scopus 로고
    • Bioinorganic Chemistry of Copper; Karlin, K. D., Tyeklár, Z., Eds.; Chapman and Hall: New York
    • Whittaker, J. W. In Bioinorganic Chemistry of Copper; Karlin, K. D., Tyeklár, Z., Eds.; Chapman and Hall: New York, 1993; pp 447-458.
    • (1993) , pp. 447-458
    • Whittaker, J.W.1
  • 50
    • 0001435450 scopus 로고
    • Sigel, H., Sigel, A., Eds.; Dekker: New York
    • Whittaker, J. W. In Metal Ions in Biological Systems; Sigel, H., Sigel, A., Eds.; Dekker: New York, 1994; Vol. 30, pp 315-360.
    • (1994) Metal Ions in Biological Systems , vol.30 , pp. 315-360
    • Whittaker, J.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.