Concise synthesis of the bicyclic core of the chromoprotein antibiotics kedarcidin and neocarzinostatin by transannular reductive cyclization of a tetrayne precursor

Tetrahedron Letters

Volumn 39, Issue 52, 1998, Pages 9633-9636

  Myers, Andrew G ^a,b   Goldberg, Steven D ^a  

^a California Institute of Technology   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; KEDARCIDIN; ZINOSTATIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL REACTION; CRYSTAL STRUCTURE; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; X RAY CRYSTALLOGRAPHY;

EID: 0032564554     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02279-5     Document Type: Article

References (22)

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22. 17. The small amount of residual olefin 9 is believed to result from the quenching of a vinyl aluminate intermediate by hexamethyldisilazane.