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10. The volume comparisons based on MM2 calculations of the side chain moieties for compounds 1-9 are as follows: 1 (100 %), 2 (102.4 %), 3 (free acid, 108.6 %), 4 (103.7 %), 5 (free acid, 113.5 %), 6 (71.3 %), 7 (96.8 %), 8 (115 %), 9 (76.9 %).
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