Synthesis and pharmacology of a new AMPA-kainate receptor agonist with potent convulsant activity

Journal of Medicinal Chemistry

Volumn 41, Issue 20, 1998, Pages 3759-3762

  Conti, P ^a   De Amici, M ^a   De Sarro, G ^a   Stensbol, T B ^a   Brauner Osborne, H ^a   Madsen, U ^a   De Micheli, C ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3A,5,6,6A TETRAHYDRO 4H PYRROLO[3,4 D]ISOXAZOLE 3,4 DICARBOXYLIC ACID; 3A,5,6,6A TETRAHYDRO 4H PYRROLO[3,4 D]ISOXAZOLE 3,6 DICARBOXYLIC ACID; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; ADENYLATE CYCLASE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR AGONIST; CONVULSANT AGENT; GLUTAMATE RECEPTOR AGONIST; GLUTAMIC ACID; IONOTROPIC RECEPTOR; KAINIC ACID; KAINIC ACID RECEPTOR AGONIST; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; PHOSPHOLIPASE C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; CHO CELL; CONTROLLED STUDY; DRUG DETERMINATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; LETTER; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ANALYSIS; TONIC CLONIC SEIZURE;

ANIMALS; CONVULSANTS; EXCITATORY AMINO ACID AGONISTS; ISOXAZOLES; MICE; PYRROLES; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; SEIZURES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032563975     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9803020     Document Type: Letter

References (23)