Characterization of postischemic behavioral deficits in gerbils with and without hypothermic neuroprotection

Brain Research

Volumn 803, Issue 1-2, 1998, Pages 69-78

  Colbourne, Frederick ^a   Auer, Roland N ^a   Sutherland, Garnette R ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

CA1; Cerebral ischemia; Gerbil; Habituation; Learning; Postischemic hypothermia; Working memory

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ENVIRONMENT; FEMALE; GERBIL; HYPOTHERMIA; ISCHEMIA; LOCOMOTION; MAZE TEST; MEMORY; NERVE CELL DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; WORKING MEMORY;

ANIMALS; BEHAVIOR, ANIMAL; BODY TEMPERATURE; BRAIN; BRAIN ISCHEMIA; CATHETERIZATION; EXPLORATORY BEHAVIOR; FEMALE; GERBILLINAE; HIPPOCAMPUS; HYPERKINESIS; HYPOTHERMIA, INDUCED; LOCOMOTION; MAZE LEARNING; NEURONS; TIME FACTORS;

EID: 0032563686     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00612-X     Document Type: Article

References (27)

1. Babcock A.M., Graham-Goodwin H. Importance of preoperative training and maze difficulty in task performance following hippocampal damage in the gerbil. Brain Res. Bull. 42:1997;415-419.
2. Babcock A.M., Baker D.A., Lovec R. Locomotor activity in the ischemic gerbil. Brain Res. 625:1993;351-354.
3. Chandler M.J., DeLeo J., Carney J.M. An unanesthetized-gerbil model of cerebral ischemia-induced behavioral changes. J. Pharmacol. Toxicol. Methods. 14:1985;137-146.
4. Colbourne F., Corbett D. Delayed and prolonged post-ischemic hypothermia is neuroprotective in the gerbil. Brain Res. 654:1994;265-272.
5. Colbourne F., Corbett D. Delayed postischemic hypothermia: a six month survival study using behavioral and histologic assessments of neuroprotection. J. Neurosci. 15:1995;7250-7260.
6. Colbourne F., Nurse S.M., Corbett D. Temperature changes associated with forebrain ischemia in the gerbil. Brain Res. 602:1993;264-267.
7. Colbourne F., Sutherland G.R., Auer R.N. An automated system for regulating brain temperature in awake and freely moving rats. J. Neurosci. Methods. 67:1996;185-190.
8. Colbourne F., Sutherland G., Corbett D. Postischemic hypothermia: a critical appraisal with implications for clinical treatment. Mol. Neurobiol. 14:1997;171-201.
9. Colbourne F., Sutherland G.R., Auer R.N. New features of delayed neuronal death in gerbils treated with prolonged postischemic hypothermia. Soc. Neurosci. Abstr. 23:1997;1917.
10. Corbett D., Crooks P. Ischemic preconditioning: a long term survival study using behavioural and histological endpoints. Brain Res. 760:1997;129-136.
11. Corbett D., Nurse S., Colbourne F. Hypothermic neuroprotection: a global ischemia study using 18-20 month old gerbils. Stroke. 28:1997;2238-2243.
12. Dietrich W.D., Busto R., Alonso O., Globus M.Y.-T., Ginsberg M.D. Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats. J. Cereb. Blood Flow Metab. 13:1993;541-549.
13. Gerhardt S.C., Boast C.A. Motor activity changes following cerebral ischemia in gerbils are correlated with the degree of neuronal degeneration in hippocampus. Behav. Neurosci. 102:1988;301-328.
14. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239:1982;57-69.
15. W.J. Loskoto, P. Lomax, M.A. Verity, A Stereotaxic Atlas of the Mongolian Gerbil Brain (Meriones unguiculatus), Ann Arbor Sci. Publ., Ann Arbor, MI, 1975.
16. Mileson B.E., Schwartz R.D. The use of locomotor activity as a behavioral screen for neuronal damage following transient forebrain ischemia in gerbils. Neurosci. Lett. 128:1991;71-76.
17. Nurse S., Corbett D. Direct measurement of brain temperature during and after intraischemic hypothermia: correlation with behavioral, physiological, and histological endpoints. J. Neurosci. 14(12):1994;7726-7734.
18. Nurse S., Corbett D. Acute and chronic locomotor patterns as predictors of ischemic outcome. Soc. Neurosci. Abstr. 21:1995;227.
19. Petito C.K., Feldmann E., Pulsinelli W.A., Plum F. Delayed hippocampal damage in humans following cardiorespiratory arrest. Neurology. 37:1987;1281-1286.
20. Pulsinelli W.A., Brierley J.B., Plum F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 11:1982;491-498.
21. Rod M.R., Whishaw I.Q., Auer R.N. The relationship of structural ischemic brain damage to neurobehavioural deficit: the effect of postischemic MK-801. Can. J. Psychol. 44:1990;196-209.
22. Volpe B.T., Waczek B., Davis H.P. Modified T-maze training demonstrates dissociated memory loss in rats with ischemic hippocampal injury. Behav. Brain Res. 27:1988;259-268.
23. Volpe B.T., Davis H.P., Towle A., Dunlap W.P. Loss of hippocampal CA1 pyramidal neurons correlates with memory impairment in rats with ischemic or neurotoxin lesions. Behav. Neurosci. 106:1992;457-464.
24. Wang D., Corbett D. Cerebral ischemia, locomotor activity and spatial mapping. Brain Res. 533:1990;78-82.
25. Whishaw I.Q., Rod M.R., Auer R.N. Behavioral deficits revealed by multiple tests in rats with ischemic damage limited to half of the CA1 sector of the hippocampus. Brain Res. Bull. 34:1994;283-289.
26. Zola-Morgan S., Squire L.R., Amaral D.G. Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. J. Neurosci. 6:1986;2950-2967.
27. F. Colbourne, R.N. Auer, G. Sutherland, Behavioral testing does not exacerbate ischemic CA1 damage in gerbils, Stroke, in press.