Inhibitory actions of synthesised polyamine spider toxins and their analogues on Ca2+-activated Cl- currents recorded from cultured DRG neurones from neonatal rats

Neuroscience Letters

Volumn 251, Issue 2, 1998, Pages 117-120

  Sutton, Kathy G ^a   Stapleton, Simon R ^b   Scott, Roderick H ^c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Argiotoxin 636; Calcium activated chloride currents; DM Nitrophen; Intracellular flash photolysis; Polyamine toxins; Synthesised FTX

Indexed keywords

ARGIOTOXIN 636; CALCIUM ION; CHLORIDE CHANNEL; POLYAMINE DERIVATIVE; SPIDER VENOM;

ANIMAL CELL; ARTICLE; BINDING SITE; CALCIUM BINDING; CALCIUM CURRENT; CALCIUM TRANSPORT; CHLORIDE CURRENT; NEUROTOXICITY; NEWBORN; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SPINAL GANGLION;

ANIMALS; ANIMALS, NEWBORN; CALCIUM; CALCIUM CHANNEL BLOCKERS; CHLORIDE CHANNELS; GANGLIA, SPINAL; MEMBRANE POTENTIALS; NEURONS; PATCH-CLAMP TECHNIQUES; POLYAMINES; RATS; RATS, WISTAR; SPIDER VENOMS;

EID: 0032563257     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00524-2     Document Type: Article

References (9)

1. Cherksey, B.D., Sugimori, M. and Llinás, R.R., Properties of calcium channels isolated with spider toxin, FTX, Proc. Natl. Acad. Sci. USA, 635 (1991) 80-89.
2. - currents in cultured rat sensory neurones by flash photolysis of DM-nitrophen, J. Physiol., 482 (1995) 291-307.
3. 2+ store in avian sensory neurons, J. Neurophysiol., 70 (1993) 710-722.
4. Kaplan, J.H. and Ellis-Davies, G.C.R., Photolabile chelators for the rapid photorelease of divalent cations, Proc. Natl. Acad. Sci. USA, 85 (1988) 6571-6575.
5. Lin, J.-W., Rudy, B. and Llinás, R.R., Funnel-web spider venom and a toxin fraction block calcium current expressed from rat brain mRNA in Xenopus oocytes, Proc. Natl. Acad. Sci. USA, 87 (1990) 4538-4542.
6. Scott, R.H., Sutton, K.G., Griffin, A., Stapleton, S.R. and Currie, K.P.M., Aspects of calcium-activated chloride currents: a neuronal perspective, Pharmacol. Ther., 66 (1995) 535-565.
7. Scott, R.H., Sweeney, M.I., Kobrinsky, E.M., Pearson, H.A., Timms, G., Pullar, I.A., Wedley, S. and Dolphin, A.C., Actions of arginine polyamine on voltage and ligand-activated whole cell currents recorded from cultured neurones, Br. J. Pharmacol., 106 (1992) 199-207.
8. 2+ currents from cultured sensory neurones by spermine, argiotoxin-636 and a synthetic arginine polyamine, Mol. Neuropharmacol., 3 (1993) 37-43.
9. Sutton, K.G., Stapleton, S.R., Timms, G., Gilmore, J., Brust, P.F., Bleakman, D. and Scott, R.H., Inhibitory actions of synthesised polyamine spider toxins and their analogues on neuronal voltage-activated calcium currents, Comp. Biochem. Physiol., 116C (1997) 23-32.