Flesinoxan treatment reduces 5-HT(1A) receptor mRNA in the dentate gyrus independently of high plasma corticosterone levels

European Journal of Pharmacology

Volumn 353, Issue 2-3, 1998, Pages 207-214

  Sibug, Rosana M ^a   Compaan, Josje C ^b   Meijer, Onno C ^c   Van Der Gugten, Jan ^b   Olivier, Berend ^b   De Kloet, E Ron ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY OF SAN FRANCISCO   (United States)

Author keywords

Corticosterone; Dentate gyrus; Dorsal raphe nucleus; Flesinoxan; Homologous regulation

Indexed keywords

CORTICOSTERONE; FLESINOXAN; MESSENGER RNA; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DENTATE GYRUS; DORSAL RAPHE NUCLEUS; DOSE RESPONSE; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; CORTICOSTERONE; DENTATE GYRUS; IN SITU HYBRIDIZATION; MALE; PIPERAZINES; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RNA, MESSENGER; SEROTONIN AGONISTS;

EID: 0032563185     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00417-8     Document Type: Article

References (37)

1. 1A receptor gene. J. Biol. Chem. 265, 5825-5832.
2. 1A receptors induces lower lip retraction in the rat. Pharmacol. Biochem. Behav. 33, 821-827.
3. Berendsen, H.H.G., Bourgondien, F.G.M., Broekkamp, C.L.E., 1994. Role of dorsal and median raphe nuclei in lower lip retraction in rats. Eur. J. Pharmacol. 263, 315-318.
4. Biegon, A., Rainbow, T.C., McEwen, B.S., 1985. Corticosterone modulation of neurotransmitter receptors in rat hippocampus: a quantitative autoradiographic study. Brain Res. 332, 309-314.
5. 1A agonist, on ACTH and PRL secretion in the rat. Neuroendocrinology 61, 159-166.
6. Bradford, L.D., 1993. Flesinoxan treatment of generalized anxiety disorder: a fixed dose, placebo controlled study. J. Psychopharmacol. Suppl.:A65.
7. 1A receptor mRNA expression. J. Neurosci. 13, 914-923.
8. 1A receptor gene expression by dexamethasone. Neuropsychopharmacology 10, 215-222.
9. 1A receptor agonist flesinoxan enhances fos immunoreactivity in rat central amygdala, bed nucleus of the stria terminalis and hypothalamus. Eur. J. Pharmacol. 8, 2340-2347.
10. De Kloet, E.R., Kovacs, G.L., Szabo, G., Telegdy, G., Bohus, B., Versteeg, D.H.G., 1982. Decreased serotonin turnover in the dorsal hippocampus of the rat brain shortly after adrenalectomy: selective normalisation after corticosterone substitution. Brain Res. 239, 659-663.
11. De Kloet, E.R., Sijbesma, H., Reul, J.M.H.M., 1986. Selective control by corticosterone of serotonin1 receptor capacity in raphe-hippocampal system. Neuroendocrinology 42, 513-521.
12. Dourish, C.T., Hutson, P.H., Curzon, G., 1985. Characteristics of feeding induced by the serotonin agonist 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT). Brain Res. Bull. 15, 377-384.
13. 1A receptor subtype increases rat plasma ACTH concentration. Eur. J. Pharmacol. 147, 431-439.
14. 1A receptor agonist, are not related to its neuroendocrine effects. Eur. J. Pharmacol. 280, 185-193.
15. 1A receptor agonist in treatment-resistant depression. Int. Clin. Psychopharmacol. 8, 167-172.
16. 1A properties of flesinoxan: in vivo electrophysiological and hypothermia study. Neuropharmacology 34, 311-1326.
17. Holmes, M.C., Yau, J.L., French, W.K.L., Seckl, J.R., 1995. The effect of adrenalectomy on 5-hydroxytryptamine and corticosteroid receptor subtype messenger RNA expression in the rat. Neuroscience 64, 327-337.
18. 1A receptor agonist. Naunyn-Schmiedeberg's Arch. Pharmacol. 364, 121-126.
19. 1A presynaptic, but not postsynpatic receptor-mediated responses: relationship to antidepressant-like action. Eur. J. Pharmacol. 138, 53-60.
20. Koenig, J.I., Gudelsky, G.A., Meltzer, H.Y., 1987. Stimulation of corticosterone and beta-endorphin secretion in the rat by selective 5-HT receptor subtype activation. Eur. J. Pharmacol. 137, 1-8.
21. Korte-Bouws, G.A.H., Korte, S.M., De Kloet, E.R., Bohus, B., 1996. Blockade of corticosterone synthesis reduces serotonin turnover in the dorsal hippocampus of the rat as measured by microdialysis. J. Neuroendocrinol. 8, 877-881.
22. 2 receptor binding and 5-HT transporter mRNA expression in rat brain. Brain Res. 648, 157-161.
23. McKittrick, C.R., Blanchard, D.C., Blanchard, R.J., McEwen, B.S., 1995. Serotonin receptor binding in a colony model of chronic social stress. Biol. Psychiatry 37, 383-393.
24. 1A receptors: functional implications of central corticosteroid receptor diversity. Ph.D. thesis. University of Leiden, Leiden.
25. 1A receptor mRNA in rat dentate gyrus. Eur. J. Pharmacol. (Mol. Pharmacol. Section) 266, 255-261.
26. 1A receptor mRNA by corticosterone. J. Neuroendocrinol. 7, 653-657.
27. 1A receptor mRNA and binding in transgenic mice with a targeted disruption of the glucocorticoid receptor. Mol. Brain Res. 46, 290-296.
28. 1B receptors in the dorsal hippocampus and cortex of the rat. Neuroendocrinology 56, 881-888.
29. Paxinos, D., Watson, C., 1986. The Rat Brain in Stereotaxic Coordinates, 2nd edn. Academic Press, San Diego, CA.
30. 1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the rat. Pharmacol. Biochem. Behav. 33, 329-334.
31. Schipper, J., Tulp, M.Th.M., Berkelman, B., Mos, J., Van der Heijden, J.A.M., Olivier, B., 1991. Preclinical pharmacology of flesinoxan: a potent anxiolytic and anti-depressant drug. Hum. Psychopharmacol. 6, S53-S61.
32. 1 receptors and offensive aggression in rats: a combined behavioural and autoradiographic study with eltoprazine. Pharmacol. Biochem. Behav. 38, 447-458.
33. 1A receptors and 5-HT-uptake sites in the hippocampus and dorsal raphe nucleus of the rat brain: an autoradiographic analysis. Psychopharmacology 113, 481-486.
34. Van Loon, G.R., Shum, A., Sole, M.J., 1981. Decreased brain serotonin turnover after short term (two-hour) adrenalectomy in rats: a comparison of four turnover methods. Endocrinology 108, 1392-1402.
35. Van Loon, G.R., Shum, A., De Souza, E.B., 1982. Triphasic changes in plasma ACTH concentration and brain serotonin synthesis rate following adrenalectomy in rats. Neuroendocrinology 34, 90-94.
36. Veldhuis, H.D., Van Koppen, C., Van Ittersum, M., De Kloet, E.R., 1982. Specificity of adrenal steroid receptor system in the rat hippocampus. Endocrinology 110, 2044-2051.
37. 1A receptors by corticosteroid hormones. Mol. Brain Res. 29, 23-34.