Capsaicin treatment induces muscarinic hyperreactivity in guinea pig trachea: A warning

European Journal of Pharmacology

Volumn 347, Issue 2-3, 1998, Pages 261-264

  Van Hoof, Helena J M ^a,b   Den Hartog, Gerardus J M ^a   Voss, Hans Peter ^a   Van Bree, Leendert ^b   Bast, Aalt ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

Guinea pig; Methacholine stimulation; Smooth muscle tracheal; Tachykinin receptor; Vanilloid receptor

Indexed keywords

CAPSAICIN; CAPSAZEPINE; METHACHOLINE; MUSCARINIC RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROPEPTIDE; TACHYKININ RECEPTOR; VANILLOID RECEPTOR;

ANIMAL TISSUE; ARTICLE; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; GUINEA PIG; MALE; NERVE FIBER C; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION; TRACHEA MUSCLE;

ANIMALS; BRONCHOCONSTRICTION; CAPSAICIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GUINEA PIGS; METHACHOLINE CHLORIDE; MUSCARINIC AGONISTS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; RECEPTORS, MUSCARINIC; RECEPTORS, TACHYKININ; TRACHEA;

EID: 0032562442     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00218-0     Document Type: Article

References (20)

1. Barnes P.J., Baraniuk J.N., Belvisi M.G. Neuropeptides in the respiratory tract. Am. Rev. Respir. Dis. 144:1991;1391-1399.
2. Bevan, S.J., Docherty, R.J., 1993. Cellular mechanisms of the action of capsaicin. In: Wood, J.N. (Ed.), Capsaicin in the Study of Pain. Academic Press, San Diego, pp. 27-42.
3. Bevan S., Hothi S., Hughes G.A., James I.F., Rang H.P., Shah K., Walpole C.S.J., Yeats J.C. Development of a competitive antagonist of the sensory neurone excitant capsaicin. Br. J. Pharmacol. 102:1991;77.
4. Bevan S., Hothi S., Hughes G.A., James I.F., Rang H.P., Shah K., Walpole C.S.J., Yeats J.C. Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin. Br. J. Pharmacol. 107:1992;544-552.
5. Constantine J.W. The spirally cut tracheal strip preparation. J. Pharm. Pharmacol. 17:1965;384-385.
6. Forsberg K., Karlsson J.-A., Theodorsson E., Lundberg J.M., Persson C.G.A. Cough and bronchoconstriction mediated by capsaicin-sensitive sensory neurons in guinea-pig. Pulm. Pharmacol. 1:1988;33-39.
7. Jimba M., Skornik W.A., Killingsworth C.R., Long N.C., Brain J.D., Shore S.A. Role of C-fibres in physiological responses to ozone in rats. J. Appl. Physiol. 78:1995;1757-1763.
8. Joos G.F., Pauwels R.A. The bronchoconstrictor effect of sensory neuropeptides in man. Ann. N.Y. Acad. Sci. 629:1991;371-382.
9. Koto H., Aizawa K., Takata S., Inoue H., Hara N. An important role of tachykinins in ozone-induced airway hyperresponsiveness. Am. J. Respir. Crit. Care Med. 151:1995;1763-1769.
10. Kuo H., Lu L. Sensory neuropeptides modulate cigarette smoke-induced decrease in neutral endopeptidase activity in guinea pig airways. Life Sci. 57:1995;2187-2196.
11. Lundberg J.M., Saria A. Polypeptide-containing neurons in airway smooth muscle. Annu. Rev. Physiol. 49:1987;557-572.
12. Lundberg J.M., Brodin E., Saria A. Effects and distribution of vagal capsaicin-sensitive substance P neurons with special reference to the trachea and lungs. Acta Physiol. Scand. 119:1983;243-252.
13. Lundberg J.M., Hokfelt T., Martling C.-R., Saria A., Cuello C. Substance P immunoreactive sensory nerves in the lower respiratory tract of various mammals including man. Cell Tissue Res. 235:1984;251-261.
14. Marek W., Potthast J.J.W., Marczynski B., Baur X. Role of substance P and neurokinin A in toluene diisocyanate-induced increased airway responsiveness in rabbits. Lung. 174:1996;83-97.
15. 3. Lung. 171:1993;109-121.
16. Saria A., Martling C.R., Yan Z., Theodorsson-Norheim E., Gamse R., Lundberg J.M. Release of multiple tachykinins from capsaicin-sensitive sensory nerves in the lung by bradykinin, histamine, dimethylphenyl piperazinium, and vagal nerve stimulation. Am. Rev. Respir. Dis. 138:1988;151-159.
17. Solway J., Leff A.R. Sensory neuropeptides and airway function. J. Appl. Physiol. 71:1991;2077-2087.
18. Tepper J.S., Costa D.L., Fitzgerald S., Doerfler D.L., Bromberg P.A. Role of tachykinins in ozone-induced acute lung injury in guinea pigs. J. Appl. Physiol. 75:1993;1404-1411.
19. Van Hoof H.J.M., Voss H.-P., Kramer K., Boere A.J.F., Dormans J.A.M.A., Van Bree L., Bast A. Changes in neuroreceptor function of tracheal smooth muscle following acute ozone exposure of guinea pigs. Toxicology. 120:1997;159-169.
20. Van Hoof H.J.M., Zijlstra F.J., Voss H.-P., Tak C.J.A.M., Van Bree L., Bast A. The role of prostanoids in ozone-induced changes in airway responsiveness: receptor activation specific prostanoid release. Environ. Toxicol. Pharmacol. 5:1998;69-78.