p-Chloroamphetamine, a serotonin-releasing drug, elicited in rats a hyperglycemia mediated by the 5-HT(1A) and 5-HT(2B/2C) receptors

European Journal of Pharmacology

Volumn 359, Issue 2-3, 1998, Pages 185-190

  Yamada, Jun ^a   Sugimoto, Yumi ^a   Yoshikawa, Tomoko ^a  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

5 HT(1A) receptor; 5 HT(2B 2C) receptor; Adrenaline; Hyperglycemia; p Chloroamphetamine

Indexed keywords

1 ISOPROPYL 6 METHYLERGOLINE 8 CARBOXYLIC ACID 2 HYDROXY 1 METHYLPROPYL ESTER; 4 AMINO 5 CHLORO 2 METHOXYBENZOIC ACID 2 (DIETHYLAMINO)ETHYL ESTER; CHLORAMPHETAMINE; FENCLONINE; KETANSERIN; METHYSERGIDE; PROPRANOLOL; RECEPTOR SUBTYPE; RITANSERIN; SEROTONIN 1A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; TROPISETRON;

ADRENAL MEDULLECTOMY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

4-AMINOBENZOIC ACID; ADRENAL MEDULLA; ADRENALECTOMY; AMINOPYRIDINES; ANIMALS; BLOOD GLUCOSE; DOSE-RESPONSE RELATIONSHIP, DRUG; ERGOLINES; FENCLONINE; HYPERGLYCEMIA; INDOLES; KETANSERIN; MALE; METHYSERGIDE; P-CHLOROAMPHETAMINE; PIPERAZINES; PROPRANOLOL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2B; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RITANSERIN; SEROTONIN; SEROTONIN AGENTS; SEROTONIN ANTAGONISTS;

EID: 0032561301     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00639-6     Document Type: Article

References (15)

1. 1A receptors. Pharmacol. Biochem. Behav. 57:1997;301-307.
2. 4 receptor activation in the mouse. Eur. J. Pharmacol. 308:1996;181-186.
3. 2 receptor agonist DOI. Eur. J. Pharmacol. 213:1992;41-46.
4. 2 receptor subtypes: a family re-united? Trends Pharmacol. Sci. 16:1995;105-110.
5. 1A and alpha-2 adrenergic receptors mediate the hyperglycemic and hypoinsulinemic effects of 8-hydroxy-2-(di-n-propylamino)tetralin in the conscious rat. J. Pharmacol. Exp. Ther. 243:1987;1159-1166.
6. 2 receptor agonists DOI and α-methyl-5-HT on plasma glucose and insulin levels in the rat. Eur. J. Pharmacol. 187:1990;435-443.
7. Chaouloff F., Laude D., Baudrie V. Ganglionic transmission is a prerequisite for the adrenaline-releasing and hyperglycemic effects of 8-OH-DPAT. Eur. J. Pharmacol. 185:1990;11-18.
8. 2 receptors are involved in the adrenal catecholamine-releasing and hyperglycemic effects of the 5-hydroxytryptamine indirect agonist D-fenfluramine in the conscious rat. J. Pharmacol. Exp. Ther. 260:1992;1008-1016.
9. Curzon G., Gibson E.L., Oluyomi A.O. Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability. Trends Pharmacol. Sci. 18:1997;21-25.
10. Fuller R.W. Effects of p-chloroamphetamine on brain serotonin neurons. Neurochem. Res. 17:1992;449-456.
11. Hoyer D. 5-HT receptors: subtypes and second messengers. J. Recept. Res. 11:1991;197-214.
12. 1C receptors mediate 1-3(chlorophenyl)piperazine-induced hypophagia. Br. J. Pharmacol. 103:1991;2016-2020.
13. 1A receptor agonist buspirone on the blood glucose and pancreatic hormones in rats. Jpn. J. Pharmacol. 60:1992;145-148.
14. 2C/2B receptor agonist 1-(3-chlorophenyl)piperazine on the plasma glucose levels of rats. Eur. J. Pharmacol. 307:1996;75-80.
15. 3 receptors mediate tachycardia in conscious instrumented dogs. J. Pharmacol. Exp. Ther. 252:1990;683-688.