Epsilon-lactam analogs of the anthelmintic cyclodepsipeptide PF1022A

Tetrahedron Letters

Volumn 39, Issue 30, 1998, Pages 5313-5316

  Dutton, Fred E ^a   Byung H, Lee ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHELMINTIC AGENT; CYCLO(DEXTRO LACTYL N METHYLLEUCYL DEXTRO 3 PHENYLLACTYL N METHYLLEUCYL DEXTRO LACTYL N METHYLLEUCYL DEXTRO 3 PHENYLLACTYL N METHYLLEUCYL); CYCLODEPSIPEPTIDE; DRUG ANALOG; LACTAM; MACROCYCLIC COMPOUND; RESIN; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DRUG CONFORMATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

EID: 0032560774     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01075-2     Document Type: Article

References (10)

1. 1. Sasaki, T.; Takag, M.; Takasi, Y.; Miyadoh, S.; Okada, T.; Koyama, M. J. Antibiotics 1992, 45, 692.
2. 2. Dutton, F. E.; Nelson, S. J. J Antibiotics 1994, 47, 1322.
3. 3. Lee, B. H.; Lee, P. H.; McWhorter Jr., W. W.; Dutton, F. E. PCT Intl. Appl. WO 97/09331, 1997.
4. 12: C, 66.51; H, 8.06; N, 5.74. Found: C, 66.23; H, 8.13; N, 5.75.
5. 5. Lee, B. H. Tetrahedron Lett. 1997, 38, 757.
6. 6. (a) DeGrado, W. F.; Kaiser, E. T. J. Org. Chem. 1980, 45, 1295.
7. (b) DeGrado, W. F.; Kaiser, E. T. J. Org. Chem. 1982, 47, 3258.
8. (c) Sasaki, T.; Kaiser, E. T. J. Org. Chem. 1191, 56, 3159.
9. 2, 10% Pd on C, EtOH, 91 %).
10. t = 12.45 min (RP-8 column, gradient: 50 to 90% acetonitrile/water + 0.1% TFA over 30 min).