Synthesis and biological activity of chimeric structures derived from the cytotoxic natural compounds dolastatin 10 and dolastatin 15

Journal of Medicinal Chemistry

Volumn 41, Issue 9, 1998, Pages 1524-1530

  Poncet, Joël ^a   Busquet, Magali ^a   Roux, Florence ^a,c   Pierré, Alain ^b   Atassi, Ghanem ^b   Jouin, Patrick ^a  

^a INSERM   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

^c Synt:em   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DOLASTATIN 10; DOLASTATIN 15; UNCLASSIFIED DRUG; VINCRISTINE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHIMERA; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; CELL DIVISION; DEPSIPEPTIDES; DRUG SCREENING ASSAYS, ANTITUMOR; HT29 CELLS; HUMANS; L CELLS (CELL LINE); MICE; OLIGOPEPTIDES; TUBULIN;

EID: 0032560188     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970800t     Document Type: Article

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