Synthetic studies on manzamine A: Construction of the tetracyclic ABCE ring substructure I

Tetrahedron Letters

Volumn 39, Issue 17, 1998, Pages 2601-2604

  Li, Shouming ^a   Yamamura, Shosuke ^a   Hosomi, Hiroki ^a   Ohba, Shigeru ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MANYGEEN; NATURAL PRODUCT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; DRUG ISOLATION; DRUG SYNTHESIS; MARINE ENVIRONMENT; SPONGE (PORIFERA);

EID: 0032560069     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00279-2     Document Type: Article

References (23)

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12. b) Nakagawa, M.; Torisawa, Y.; Hosaka, T.; Tanabe, K.; Da-te, T.; Okamura, K.; Hino, T. ibid., 1993, 34, 4543;
13. c) Winkler, J. D.; Siegel, M. G.; Stelmach, J. E. ibid., 1993, 34, 6509;
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16. 6. The spectral data for the new compounds cited herein are in accord with the structure assigned.
17. 1/a, a=11.626(3), b=8.078(4), c = 30.408(4) Å β=92.00(2)°, V=2854.0(16) Å3, Z=4, R=0.083 for 2902 reflections. (figure presented) Fig. The ORTEP Drawing of 4.
18. 8. Braun, L. M.; Braun, M. A.; Crissman, H.R.; Opperman, M.; Adams, R. M. J. Org. Chem., 1971, 36(16), 2388.
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20. 2, THF, -78°C.
21. 11. Mitsunobu, O. Synthesis, 1981, 1.
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23. 3) δ(ppm): 22.7, 23.0, 23.2, 24.6, 26.3, 27.0, 29.7, 33.9, 34.0, 39.2, 41.4, 44.2, 47.5, 50.16, 50.22, 52.8, 54.7, 61.1, 78.2, 130.8, 132.9, 156.5.