Combination of elevated maternal serum alpha-fetoprotein (MSAFP) and low estriol is highly predictive of anencephaly

American Journal of Medical Genetics

Volumn 75, Issue 3, 1998, Pages 297-299

  Yaron, Yuval ^a,b   Hamby, Deborah D ^b   O'Brien, Joseph E ^c   Critchfield, Gregory ^c   Leon, Jorge ^c   Ayoub, Mazin ^a,b   Johnson, Mark P ^a,b   Evans, Mark I ^a,b  

^a HUTZEL HOSPITAL   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c QUEST DIAGNOSTICS NICHOLS INSTITUTE   (United States)

Author keywords

Anencephaly; Estriol; Neural tube defects; Prenatal diagnosis

Indexed keywords

ALPHA FETOPROTEIN; ESTRIOL;

ANENCEPHALUS; ARTICLE; DIAGNOSTIC ACCURACY; ESTRIOL BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MATERNAL SERUM; NEURAL TUBE DEFECT; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; PROGNOSIS; SECOND TRIMESTER PREGNANCY; THIRD TRIMESTER PREGNANCY;

ALPHA-FETOPROTEINS; ANENCEPHALY; ESTRIOL; FEMALE; GENETIC MARKERS; GENETIC SCREENING; HUMANS; NEURAL TUBE DEFECTS; PREDICTIVE VALUE OF TESTS; PRENATAL DIAGNOSIS; RETROSPECTIVE STUDIES;

EID: 0032559319     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19980123)75:3<297::AID-AJMG14>3.0.CO;2-K     Document Type: Article

References (10)

1. Allen JP, Greer MA, McGilvra R, Castro A, Fisher DA (1974): Endocrine function in an anencephalic infant. J Clin Endocrinol 38:94.
2. Brock DJ, Sutcliffe RG (1972): Alpha-fetoprotein in the antenatal diagnosis of anencephaly and spina bifida. Lancet 2:197-199.
3. Dean L, Abell DA, Beischer NA (1977): Incidence of anencephaly and other major malformations when oestriol excretion is very low. Brit Med J 1:257-258.
4. Frandsen VA, Stakemann G (1961): The site of production of oestrogenic hormones in human pregnancy. Acta Endocrinol 38:383.
5. Kostiuk EV, Zolotukhina TV, Kuznetsov MI (1992): Significance of the maternal levels of serum alpha-fetoprotein, human chorionic gonadotropin and unconjugated estriol in various congenital developmental defects in pregnancy trimester II. Genetika 28:158-162.
6. MacDonald PC, Siitreri PK (1965): Origin of oestrogen in women pregnant with an anencephalic fetus. J Clin Invest 44:465.
7. Sagen N, Ulstein M, Romslo I, Stoa KF (1979): Plasma estriol, progesterone, cortisol, placental lactogen and alpha-fetoprotein in a pregnancy with an anencephalic fetus followed from the seventh week till term. Acta Obstetricia et Gynecologica Scandinavica 58:305-307.
8. Shahwan MM, Oakey RE, Stitch SR (1968): The conversion of pregnenolone to progesterone and 16 alpha-hydroxydehydroepiandrosterone in vitro by adrenal tissue from a newborn anencephalic infant. J Endocrinol 40:29-35.
9. Tulchinsky D, Osathanondh R, Belisle S, Ryan KJ (1977): Plasma estrone, estradiol, estriol, and their precursors in pregnancies with anencephalic fetuses. J Clin Endocrinol 45:1100.
10. Wald NJ, Brock DJ, Bonnar J II (1974): Prenatal diagnosis of spina bifida and anencephaly by maternal serum-alpha-fetoprotein measurement. A controlled study. Lancet 1:765-776.