Efficient synthesis of 2-trihalomethyl-5-cyanopyridines

Tetrahedron Letters

Volumn 39, Issue 43, 1998, Pages 7965-7966

  Cooke, Jason W B ^a   Coleman, Mark J ^a   Caine, Darren M ^a   Jenkins, Kevin P ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PYRIDINE DERIVATIVE;

ARTICLE; BROMINATION; CATALYSIS; CYCLIZATION; ISOMERISM; REACTION ANALYSIS; SYNTHESIS;

EID: 0032558664     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01731-6     Document Type: Article

References (5)

1. 1 Cocco MT, Congiu C and Onnis V. J. Heterocycl. Chem. 1995, 32, 543-545.
2. 2 Isolated as essentially a single double bond isomer.
3. 3 Initially this cyclisation was carried out with ammonia in methanol which gave rise to unidentified by-products.
4. 4 Colla A, Martins MAP, Clar G, Krimmer S and Fischer P. Synthesis 1991, 483-486.
5. 5 We are grateful to Eleanor Wright, a work experience student, for repeating some experiments.