General synthesis of 3-substituted alkenyl GABA as potential anticonvulsants

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 18, 1998, Pages 2599-2602

  Serfass, Lucile ^a,c   Casara, Patrick J ^a,b  

^a SANOFI   (France)

^b IDRS   (France)

^c University of Wisconsine Madison   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID DERIVATIVE; ALKADIENE; AMINO ACID; ANTICONVULSIVE AGENT; BENZODIAZEPINE DERIVATIVE; GABAPENTIN; GLUTAMATE DECARBOXYLASE; VALPROIC ACID; VIGABATRIN;

ARTICLE; BLOOD BRAIN BARRIER; CATALYSIS; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME INHIBITION; NEUROTRANSMISSION; NONHUMAN; STEREOSPECIFICITY;

ANTICONVULSANTS; GAMMA-AMINOBUTYRIC ACID; MODELS, CHEMICAL; STEREOISOMERISM; VIGABATRIN;

EID: 0032558524     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00465-X     Document Type: Article

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11. 1H NMR,MS) and elemental analyses (CHN) in agreement with the assigned structures. For experimental details see Serfass, L., PhD thesis 95/STR1/2037. Strasbourg 1995.