Functional characteristics of a series of N4-substituted 1-(2,3-dihydro- 1,4-benzodioxin-5-yl)piperazines as 5-HT(1A) receptor ligands. Structure- activity relationships

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 18, 1998, Pages 2457-2462

  Van Steen, B J ^a   Van Wijngaarden, I ^a   Ronken, E ^a   Soudija, W ^b  

^a Solvay Pharmaceuticals Inc   (Netherlands)

^b Clinical Pharmacology   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BENZODIOXIN DERIVATIVE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ADENYLATE CYCLASE; BUTYROPHENONE DERIVATIVE; CYCLIC AMP; FLESINOXAN; FORSKOLIN; IPSAPIRONE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PARTIAL AGONIST; PHTHALIMIDE DERIVATIVE; PIPERAZINE DERIVATIVE; SACCHARIN DERIVATIVE; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; CHO CELL; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; FRONTAL CORTEX; LIGAND BINDING; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ADENYLATE CYCLASE; ANIMALS; CHO CELLS; CRICETINAE; FRONTAL LOBE; HUMANS; LIGANDS; MODELS, CHEMICAL; PIPERAZINES; PYRIDINES; PYRIMIDINES; RATS; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032558507     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00406-5     Document Type: Article

References (8)

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7. 50 is the median effective dose of the Iigand used. Full antagonists block the effect of 8-OH-DPAT for 100%. The efficacy of a compound is expressed as a percentage ranging from 0-100%.
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