Randomised placebo-controlled trial of use of topical recombinant bovine basic fibroblast growth factor for second-degree burns

Lancet

Volumn 352, Issue 9141, 1998, Pages 1661-1664

  Fu, Xiaobing ^a   Shen, Zuyao ^b   Chen, Yulin ^c   Xie, Junhe ^d   Guo, Zhenrong ^a   Zhang, Mingliang ^b   Sheng, Zhiyong ^a  

^a 304TH HOSPITAL   (China)

^b Jishuitan Orthopaedic College of Tsinghua University   (China)

^c Burn Unit   (China)

^d SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; PLACEBO; RECOMBINANT BASIC FIBROBLAST GROWTH FACTOR;

ARTICLE; BURN; CLINICAL EXAMINATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; EPIDERMIS; GRANULATION TISSUE; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; PHOTOGRAPHY; PRIORITY JOURNAL; PUNCH BIOPSY; RANDOMIZED CONTROLLED TRIAL; SKIN GRAFT; TISSUE REGENERATION; TOPICAL DRUG ADMINISTRATION; WOUND HEALING;

EID: 0032556494     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(98)01260-4     Document Type: Article

References (30)

1. 1 Cohen IK. An overview of wound healing biology. In: Ziegler TR, Pierce GF, Herndon DN, eds. Growth factors and wound healing: basic science and potential clinical applications. New York: Springer, 1997: 3-7.
2. 2 Lazarus GS, Copper DM, Knighton DR, et al. Definitions and guidelines for assessment of wounds and evaluation of healing. Arch Dermatol 1994; 130: 489-93.
3. 3 Bennett NT, Schultz GS. Growth factors and wound healing: biochemical properties of growth factors and their receptors. Am J Surg 1993; 165: 728-37.
4. 4 Bennett NT, Schultz GS. Growth factors and wound healing, part II: role in normal and chronic wound healing. Am J Surg 1993; 166: 74-81.
5. 5 Steed DL, Group DUS. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity diabetic ulcers. Vasc Surg 1995; 21: 71-81.
6. 6 Nanney LB. Epidermal and dermal effects of epidermal growth factor during wound repair. J Invest Dermatol 1990; 94: 624-29.
7. 7 Schultz GS, Rotatori SD, Clark W. EGF and TGFα in wound healing and repair. J Cell Biochem 1991; 45: 346-52.
8. 8 Bhora FY, Dunkin BJ, Batzri S, et al. Effect of growth factors on cell proliferation and epithelialization in human skin. J Surg Res 1995; 59: 236-44.
9. 9 Fu XB, Guo ZR, Sheng ZY, Ling XQ, He C. Basic fibroblast growth factor and its use in trauma and disease treatment (485 cases). J Milit Surg 1996; 8: 31-33.
10. 10 Pruitt BA Jr, ed. Symposium: progress in burn care. World J Surg 1992; 16: 1-96.
11. 11 Hunt TK. Physiology of wound healing. In: Clowes GHI Jr, ed. Trauma, sepsis and shock: the physiological basis of therapy. New York: Marcel Dekker, 1988: 443-71.
12. 12 Appleton I. Wound repair: the role of cytokines and vasoactive mediators. J R Soc Med 1994; 87: 500-02.
13. 13 Hunt TK. Can repair processes be stimulated by modulators (cell growth factors, angiogenic factors, etc) without adversely affecting normal processes. J Trauma 1984; 24: S39-46.
14. 14 Brown GL, Nanney LB, Griffen J, et al. Enhancement of wound healing by topical treatment with epidermal growth factor. N Engl J Med 1989; 321: 76-79.
15. 15 Gilpin DA, Barrow RE, Rutan RL, Broemeling L, Herndon DN. Recombinant human growth hormone accelerates wound healing in children with large cutaneous burns. Ann Surg 1994; 220: 19-4.
16. 16 Gibran NS, Isik FF, Heimbach DM, Gordon D. Basic fibroblast growth factor in the early human burn wound. J Surg Res 1995; 56: 226-34.
17. 17 Villaschi S, Nicosia RF. Angiogenic role of endogenous basic fibroblast released by rat aorta after injury. Am J Pathol 1993; 143: 181-90.
18. 18 Baird A, Walicke PA. Fibroblast growth factor. Br Med Bull 1989; 45: 438-52.
19. 19 Lindner V, Lappi DA, Baird A, Majack RA, Reidy MA. Role of basic fibroblast growth factor in vascular lesion formation. Circ Res 1991; 86: 106-13.
20. 20 Rapraeger AC, Krufka A, Olwin BB. Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myofibroblast differentiation. Science 1991; 252: 1705-08.
21. 21 Hoppenreijs VP, Pels E, Vrensen GF, Treffers WF. Basic fibroblast growth factor stimulates corneal endothelial cell growth and endothelial wound healing of human corneas. Invest Ophthalmol Vis Sci 1994; 35: 931-44.
22. 22 Gospodarowicz D, Plouet J, Malerstein J, et al. Comparison of the ability of basic and acidic fibroblast growth factor to stimulate the proliferation of an established keratinocyte cell line. J Cell Physiol 1990; 142: 325-35.
23. 23 Nicosia R, Nicosia S, Smith M. Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro. Am J Pathol 1994; 145: 1023-29.
24. 24 Roesel JF, Nanney LB. Assessment of different cytokine effects on angiogenesis using an vivo model of cutaneous wound repair. J Surg Res 1995; 58: 449-59.
25. 25 Danilenko DM, Ring BD, Tarpley JE, et al. Growth factors in porcine full and partial thickness burn repair: differing targets and effects of kernatocyte growth factor, platelet-derived growth factor-BB, epidermal growth factor, and neu differentiation factor. Am J Pathol 1995; 147: 1261-77.
26. 26 Fu XB, Cuevas P, Gimenez-Gallego G, Martinez-Murillo R, Tian HM, Sheng ZY. Ischemia and reperfusion reduce the endogenous basic fibroblast growth factor in rat skeletal muscles: an immunohistochemical study. Wound Rep Reg 1996; 4: 385-89.
27. 27 Fu XB, Cuevas P, Gimenez-Gallego G, Tian HM, Sheng ZY. Acidic fibroblast growth factor reduces renal morphologic and functional indicators of injury caused by ischemia and reperfusion. Wound Rep Reg 1996; 4: 297-303.
28. 28 Fu XB, Wang YP, Chang GU, Wang DW, Sheng ZY. Role of fibroblast growth factor (bFGF) in incised wound healing in pigs. Chin J Trauma 1995; 11: 134-36.
29. 29 Nguyen M, Watanabe H, Budson AE, Richie JP, Folkman J. Elevated levels of an angiogenic peptides, basic fibroblast growth factor, in urine of patients with a wide spectrum of cancers. J Natl Cancer Inst 1993; 86: 356-61.
30. 30 Li VW, Folkerth RD, Watanabe H, et al. Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumours. Lancet 1994; 344: 82-86.