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Volumn 8, Issue 14, 1998, Pages 1929-1934

SAR studies of diaryltriazoles against bacterial two-component regulatory systems and their antibacterial activities

Author keywords

[No Author keywords available]

Indexed keywords

DIARYLTRIAZOLE; SALICYLANILIDE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0032555253     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00325-4     Document Type: Article
Times cited : (46)

References (17)
  • 4
    • 0001792698 scopus 로고
    • Hoch, J. A.; Silhavy T. J., Eds.; ASM; Washington, D. C.
    • 4. Two-Component Signal Transduction; Hoch, J. A.; Silhavy T. J., Eds.; ASM; Washington, D. C., 1995; pp 25-51.
    • (1995) Two-component Signal Transduction , pp. 25-51
  • 9
    • 0029118628 scopus 로고
    • 9. It is worth noting that recent studies revealed that such systems exist in lower eucaryotes such as yeast and fungi, e.g. Crovello, C. S.; Furie, B. C.; Furie, B. Cell, 1995, 82, 279.
    • (1995) Cell , vol.82 , pp. 279
    • Crovello, C.S.1    Furie, B.C.2    Furie, B.3
  • 12
    • 0010490686 scopus 로고    scopus 로고
    • note
    • 50 values are the mean of two experimental determinations.
  • 13
    • 0010484293 scopus 로고    scopus 로고
    • note
    • 13. In vitro minimum inhibitory concentration against a panel of Gram-positive bacteria: S. aureus (ATCC29213), MRSA (OC2089), E. faecalis (OC3041), E. faecium (OC3312, vancomycin resistant). Determination of susceptibility was performed following the broth microdilution method of the National Committee for Clinical Laboratory Standards.
  • 16
    • 0010521961 scopus 로고    scopus 로고
    • note
    • I, the nitrogen regulatory proteins from E. coli.
  • 17
    • 0010482864 scopus 로고    scopus 로고
    • note
    • 17. This is a whole cell assay to monitor the function of the VanS/VanR two-component system that activates vancomycin resistance in enterococcus. High level resistance to vancomycin is determined by a group of adjacent genes organized as an operon, whose expression is under the control of the VanS/VanR two-component system. This assay measures the enzymatic activity of firefly luciferase (luc) expressed from a protein fusion to vanH, the first gene of the operon. The presence of vancomycin causes the histidine kinase to autophosphorylate and to transfer this phosphate to VanR. Phosphorylated VanR acts as a transcriptional activator of the promoter of the operon located upstream of vanH. Thus, it upregulates transcription of downstream genes, resulting in increased luciferase expression.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.