Inhibition of lipid peroxidation mediated by indolizines

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 14, 1998, Pages 1829-1832

  Nasir, Achmad Izuddin ^a   Gundersen, Lise Lotte ^a   Rise, Frode ^a   Antonsen, Øyvind ^b   Kristensen, Trond ^b   Langhelle, Bjarte ^b   Bast, Aalt ^c   Custers, Ilse ^c   Haenen, Guido R M M ^c   Wikström, Håkan ^d  

^a UNIVERSITY OF OSLO   (Norway)

^b Department of Natural Science   (Norway)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INDOLIZINE DERIVATIVE;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; HEART INFARCTION; LIPID PEROXIDATION; RHEUMATOID ARTHRITIS; STROKE;

EID: 0032555109     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00313-8     Document Type: Article

References (23)

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13. 5. Compounds 4a, 4b, and 4d were prepared essentially as described in ref. 2a; compounds 4g and 4h were prepared according to ref. 2d.
14. 3, 200 MHz): δ 2.31 (3H, s), 2.47 (3H, s), 6.3-6.5 (1H, dd), 7.20-7.40 (12H, m), 8.11 (1H, s). The compounds 4c and 4f were prepared by the same procedure except that palmitoyl chloride was used in the synthesis of 4c; yields 48 % of 4c and 60 % of 4f.
15. 50 values were calculated from the concentrations of the compounds that gave a protection just above and below 50 % compared to the control incubation without the compound.
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22. 3, 200 MHz): δ 3.73 (3H, s), 6.77 (1H, dd), 7.1-7.4 (10H, M), 7.75 (1H, d), 7.92 (1H, s), 9.75 (1H, s).
23. 3, 200 MHz): δ 6.91 (1H, s), 7.2-7.4 (16H, m), 7.83 (1H, s), 7.89 (1H, d), 9.72 (1H, s).