Synthesis of novel antifungal agents (2)

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 14, 1998, Pages 1825-1828

  Tsukuda, Takuo ^a   Watanabe, Masami ^a   Ontsuka, Hitomi ^a   Hattori, Kazuo ^a   Shirai, Michio ^a   Shimma, Nobuo ^a  

^a NIPPON ROCHE RESEARCH CENTER   (Japan)

Author keywords

Antimicrobial; Chemotherapy; Fungi

Indexed keywords

ANTIFUNGAL AGENT; RESTRICTICIN DERIVATIVE; RO 09 2427; RO 09 2473; RO 09 2474; RO 09 2550; RO 09 2593; RO 09 2684; RO 09 2687; RO 09 2711; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; DRUG STRUCTURE; DRUG SYNTHESIS; MYCOSIS; NONHUMAN;

ANIMALS; ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CRYPTOCOCCUS NEOFORMANS; MICE; MICROBIAL SENSITIVITY TESTS;

ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; FUNGI;

EID: 0032555107     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00315-1     Document Type: Article

References (9)

1. 1) a) Matsukuma, S.; Ohtsuka, T.; Kotaki, H.; Shirai, H.; Sano, T.; Watanabe, K.; Nakayama, N.; Itezono, Y.; Fujiu, M.; Shimma, N.; Yokose, K.; Okuda, T. J. Antibiot. 1992, 45, 151.
2. b) Aoki, Y.; Yamazaki, T.; Kondo, M.; Sudoh, Y; Nakayama, N.; Sekine, Y.; Shimada, H.; Arisawa, M. J. Antibiot. 1992,45,160.
3. 2) Testa, B. In Burger's Medicinal Chemistry and Drug Discovery Volume 1 ; Wolff M.E., Ed.; A Wiely-interscience publication: New York 1995 129.
4. 3) The previous papaer of this issue
5. 4) Strikrishna, A. Synthetic Commun. 1992, 22, 1221.
6. 5) All new compounds gave spectroscopic data in agreement with the assigned structures.
7. 6) Tsukuda, T.; Watanabe, M.; Ontsuka, H.; Fujimoto, Y.; Shimma, N. Bioorg. Med. Chem. Lett. , 1994, 4, 733.
8. 7) In the previous paper of this issue we found C-3 derivatives possessing oxime group (e.g. Ro09-2183 and 2435) showed broad in vitro antifungal spectrum including Asp. fumigatus.
9. 80=0.24 μg/ml.